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Cancer Of The Salivary Gland
cancer of the salivary gland The salivary glands The salivary glands make saliva (spit). This keeps your mouth moist and helps food to slide down the gullet, into the stomach. The largest salivary glands are the: * sublingual glands – found underneath the tongue * parotid glands – at the sides of the mouth just in front of the ears * submandibular glands – under the jawbone. There are also many more tiny glands in the lining of the mouth and throat. These do not have individual names but are known as the minor salivary glands. back to top Salivary gland cancer Cancers affecting the salivary glands are rare. Approximately 550 new cases of are diagnosed in the UK each year. They can occur at any age, but are more common in people over 50. There are different types of salivary gland cancer, depending on the type of cell that has become cancerous. back to top Causes Like many other forms of cancer, the exact causes are unknown. Non-cancerous (benign) tumours of the salivary glands are more common than cancerous (malignant) tumours. Tumours affecting the salivary glands are not infectious, and can't be passed on to other people. They are not caused by an inherited faulty gene, so the relatives of someone with aren't likely to develop it. back to top Signs and symptoms The most common symptom of is a swelling on the side of the face, just in front of the ears, or under the jawbone. Some people also have some numbness and drooping of one side of the face (facial palsy). These symptoms may occur with conditions other than cancer, and most people with these symptoms will not have a salivary gland cancer. However, like most cancers, salivary gland cancers are best treated when diagnosed at an early stage. You should report any of the above symptoms to your GP if they do not improve over a few days. back to top How it is diagnosed Your GP will examine you and arrange for any tests that may be necessary. You will need to be referred to a hospital specialist for these tests, and for expert advice and treatment. The specialist at the hospital will ask about your general health and any previous medical problems, before examining you. They may arrange blood tests to check your general health. The following tests are commonly used to diagnose salivary gland cancer: CT (computerised tomography) scan This is a sophisticated type of x-ray which builds up a detailed three-dimensional picture of the inside of the body. The scan is painless but takes about 15 minutes. It may be used to identify the exact size of the tumour, or to check for any spread of the cancer. Most people who have a CT scan are given a drink or injection of a fluid that allows particular areas to be seen more clearly. If you are allergic to iodine or have asthma it is important to tell the person doing this test before you have the injection. MRI (magnetic resonance imaging) scan This type of scan uses magnetism instead of x-rays to form a series of cross-sectional pictures of the inside of the body. During the scan you will be asked to lie very still on a couch inside a metal cylinder. You will usually be given an injection to allow the picture to be seen more clearly. The test can take up to an hour and is completely painless. If you don't like enclosed spaces you may find the machine claustrophobic. The machine is also quite noisy, but you will be given earplugs or headphones to wear. Biopsy The doctor may use a fine needle and syringe to take a sample of cells from the affected area, to examine under a microscope. Alternatively, a small piece of tissue may be taken from the area. This procedure is usually performed under either a general or local anaesthetic. back to top Staging and grading Staging The stage of a cancer is a term used to describe its size and whether or not it has spread beyond its original site. Knowing the particular type and the stage of the cancer helps the doctors to decide on the most appropriate treatment for you. Cancer can spread in the body, either in the bloodstream or through the lymphatic system. The lymphatic system is part of the body's defence against infection and disease. The system is made up of a network of lymph glands (or nodes) that are linked by fine ducts containing lymph fluid. Your doctors will usually look at the lymph nodes close to the salivary glands, in order to assess the stage of your cancer. The most commonly used staging system is called the TNM system. * T refers to the tumour size. * N refers to whether or not lymph nodes are affected. * M refers to whether or not the cancer has spread to other parts of the body (metastases). Tumour size (T) * T1 The cancer is no bigger than 2cm in size and has not begun to spread. * T2 The cancer is 2–4cm in size but has not begun to spread. * T3 The cancer is bigger than 4cm and may have spread into nearby soft tissue. * T4a The cancer is of any size, but it has spread to the skin, jaw-bone, ear-canal or facial nerves. * T4b The cancer is of any size, but it has spread to other nearby bones, the base of the skull or the carotid artery. Lymph nodes (N) * N0 None of the lymph nodes are affected. * N1 The cancer has spread to one lymph node on the same side of the neck as the tumour. The affected node is 3cm or smaller. * N2a The cancer has spread to one lymph node on the same side of the neck as the tumour. The node is 3–6cm in size.

Obese Colon Cancer Survivors Face Poorer Prognosis (HealthDay)
HealthDay - TUESDAY, March 9 (HealthDay News) -- Colon cancer survivors who are moderately or severely obese face tougher survival odds following treatment compared with their normal-weight peers, a new study reveals.
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HealthDay - MONDAY, March 8 (HealthDay News) -- Two proteins that might serve as biomarkers for predicting the spread of colon cancer have been identified by Chinese scientists.
New Treatment Eyed for Deadly Pancreatic Cancer (HealthDay)
HealthDay - FRIDAY, Feb. 26 (HealthDay News) -- Most pancreatic cancer patients die soon after diagnosis, but researchers have identified an oncogene that appears to be a promising new treatment target.
Hormone replacement tied to lung cancer risk (Reuters)
Reuters - Women who use hormone replacement therapy combining estrogen and progestin may have a higher risk of lung cancer than non-users, a new study finds.
Scientists Spot Genetic 'Fingerprints' of Individual Cancers (HealthDay)
HealthDay - THURSDAY, Feb. 18 (HealthDay News) -- Researchers have found a way to analyze the "fingerprint" of a cancer, and then use that fingerprint to track the trajectory of that particular tumor in that particular person.
US researchers harness DNA changes to develop cancer test (AFP)
AFP - US researchers unveiled a new way to fight cancer Thursday that uses the unique changes that occur in the DNA of cancerous cells to detect even the tiniest of cancers.
US researchers harness DNA changes to develop cancer test (AFP)
AFP - US researchers unveiled a new way to fight cancer Thursday that uses the unique changes that occur in the DNA of cancerous cells to detect even the tiniest of cancers.
New way of tracking cancer uses DNA changes: US study (AFP)
AFP - US researchers have developed a new way of tracking and fighting cancer, using patient-specific biomarkers from the DNA of individual cancer tumors, a study published Thursday showed.
Occasional binges may undo alcohol's heart benefits (Reuters)
Reuters - While research has linked moderate drinking to better heart health, a new study suggests that those benefits disappear when drinkers add the occasional binge to the mix.
Genome study shows what cancers have in common (Reuters)
Reuters - Genetic abnormalities -- missing DNA or duplicate DNA -- that fuel the growth of one type of cancer may actually be at work in several others, U.S. researchers said on Wednesday.

* N2b The cancer has spread to more than one lymph node on the same side of the neck as the tumour. None of them are larger than 6cm in size. * N2c The cancer has spread to one or more lymph nodes on both sides of the neck, or on the opposite side to the tumour. None of the nodes are larger than 6cm in size. * N3 The affected lymph nodes are larger than 6cm in size. Metastases (M) * M0 The cancer has not spread to other parts of the body. * M1 The cancer has spread to other parts of the body such as the lungs. Grading Grading refers to the appearance of the cancer cells under the microscope, and gives an idea of how quickly the cancer may develop. Low-grade means that the cancer cells look very like normal cells; they are usually slow-growing and are less likely to spread. In high-grade tumours the cells look very abnormal, are likely to grow more quickly, and are more likely to spread. back to top Treatment Salivary gland cancers can start in various cells within the salivary glands and may be slow- or fast-growing. The type of treatment given will depend on a number of things, including the position of the cancer, the exact type of cancer, and your general health. The following treatments may be used alone or in combination with one another. Surgery Surgery may be used to remove the salivary gland. Your doctor will discuss the operation with you beforehand and will tell you about any possible side effects. The doctor may sometimes recommend surgery to remove any affected lymph nodes in the neck. There is a network of lymph nodes (lymph glands) throughout the body and they form part of the body's natural defence against infection. The lymph nodes are connected by a network of fine tubes known as lymph vessels. Radiotherapy Radiotherapy may be used to treat salivary gland cancers. Radiotherapy uses high-energy rays to destroy cancer cells, while doing as little harm as possible to normal tissue. During and after radiotherapy treatment to the salivary glands, your salivary glands will produce less saliva and this may affect your eating. It is important to see a dentist regularly if you have a dry mouth. Keeping your mouth clean is very important, and your doctors and nurses will advise you about this. It can be helpful to visit a dentist before starting radiotherapy to make sure your mouth is as healthy as possible. This can help to prevent side effects developing in the future. If you need to have any teeth removed before treatment you should wait at least two weeks before starting radiotherapy to the salivary glands. If it is necessary to have a tooth removed after treatment this should be done by a hospital specialist. Side effects of radiotherapy usually decrease gradually once the treatment has ended. Some people find that their salivary glands are permanently altered. It is important to discuss this with your doctor and dentist as it is often possible to find ways of reducing any problems. Your doctor or a dietitian at the hospital may be able to give you further advice if this problem occurs. Chemotherapy This is the use of anti-cancer (cytotoxic) drugs to destroy cancer cells. Although helpful for many types of cancer, chemotherapy is not very effective in treating salivary gland cancers and is used only occasionally. back to top Research trials You may be offered chemotherapy as part of a research trial. Before any trial is allowed to take place it must have been approved by the ethics committee, which checks that the trial is in the interest of patients. You may be asked to take part in a clinical trial. Your doctor must discuss the treatment with you so that you have a full understanding of the trial and what it involves. You may decide not to take part, or to withdraw from a trial at any stage. You will then receive the best standard treatment available. back to top Follow-up You will have regular check-ups once your treatment has finished. These will often continue for several years, frequently at first and then less often. Let your doctor know if you have any problems or notice any symptoms between visits. back to top Your feelings During your treatment you are likely to experience a number of different emotions, from shock and disbelief to fear and anger. At times emotions can be overwhelming and hard to control. These feelings are quite natural. It is important, to be able to express them. Each individual has their own way of coping with difficult situations; some people find it helpful to talk to friends or family, while others prefer to seek help from people outside their situation. Some people prefer to keep their feelings to themselves. There is no right or wrong way to cope, but help is available if you need it. You may wish to contact our cancer information nurse specialists about counselling in your area. back to top References This section has been compiled using information from a number of reliable sources, including: * Improving Outcomes in Head and Neck Cancers. National Institute for Health and Clinical Excellence (NICE). November 2004. * Oxford Textbook of Oncology (2nd edition). Eds Souhami et al. Oxford University Press, 2002. * Cancer and its Management (5th edition). Eds Souhami and Tobias. Oxford Blackwell Scientific Publications, 2005. * The Textbook of Uncommon Cancers (3rd edition). Eds Raghavan et al. Wiley, 2006. * Cancer: Principles and Practice of Oncology (7th edition). Eds DeVita et al. Lippincott, Williams and Wilkins, 2005.

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High-risk human papillomavirus type 18 E7 caused p27 elevation and cytoplasmic localization.
Authors: Yan X, Shah W, Jing L, Chen H, Wang Y The tumor suppressor p27(Kip1) is an inhibitor of cyclin/cyclin-dependent kinase (CDK) complexes and plays a crucial role in cell cycle regulation. Nevertheless, p27 function in the tumorigenesis of the uterine cervix has been poorly defined. Some phenomenon hints that HPV E7 protein can enhance p27 expression, which is contradictory to HPV E7's property of increasing cell proliferation rate. So, in the present study, we have examined the effect of E7 on p27 expression. Though the levels of p27 are increased after HPV E7 expression, most of the p27 protein localized in the cytoplasm and have no function on cell cycle arrest and contact inhibition. The cell migration rate is elevated when p27 is high expression and located in cytoplasm. The...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
[Comment] Radiotherapy for endometrial cancer: a key piece in the jigsaw
With a rising yearly incidence of more than 20 women per 100 000, endometrial cancer is now the most common gynaecological cancer in developed countries. More than 75% of patients present with disease confined to the uterus. After hysterectomy and bilateral salpingo-oophorectomy, histopathological variables are used to assign risk of recurrence. Endometrial cancer of high-intermediate risk accounts for around 30% of women with early disease, of whom about 15% either have occult metastases or will develop metastatic disease. Adjuvant treatment to reduce the risk of recurrence has traditionally been external beam radiotherapy (EBRT), which is presently offered to about a third of women with endometrial cancer, with or without vaginal brachytherapy (VBT). However, although EBRT reduces the r...
Pelvic radiotherapy and the risk of secondary leukemia and multiple myeloma
Although several studies had examined secondary malignancies in patients with specific primary tumor types, to the authors' knowledge there are very few data examining the long-term sequelae of pelvic radiation as a whole. The goal of the current study was to examine the risk of treatment-associated leukemia and multiple myeloma in patients treated with pelvic radiotherapy.Patients with invasive tumors of the vulva, cervix, uterus, anus, and rectosigmoid treated from 1973 to 2005 and recorded in the Surveillance, Epidemiology, and End Results (SEER) database were analyzed. Patients were stratified based on receipt of pelvic radiotherapy. The incidence of secondary leukemia (except chronic lymphocytic leukemia) and multiple myeloma were examined. Multivariate Cox proportional hazards models...
Invasive carcinoma of the uterine cervix associated with pregnancy
This study is a representation of 90 years of experience with carcinoma of the uterine cervix in pregnancy. The objective was to retrospectively study changes in the distribution of cervical carcinoma (CC) by age, disease stage, histopathology, survival, and the development of second primary cancers.Altogether, 18,474 women with newly diagnosed CC were examined and treated at the Radiumhemmet between 1914 and 2004, including 9247 women who were of a childbearing age ( (Source: Cancer)
Human papillomavirus type 16 E5 protein inhibits hydrogen peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells
To investigate the mechanism by which the human papillomavirus (HPV) E5 protein contributes to the carcinogenesis of uterine cervical cancer, we studied the effect of HPV E5 on apoptosis of cervical cancer cells and its underlying mechanism. Expression of HPV16 E5 protein inhibited hydrogen peroxide-induced apoptosis in C-33A cervical cancer cells. E5 decreased the expression of Bax protein, and exogenous expression of Bax abolished the anti-apoptotic effect of E5. Knockdown of E5 by small interfering RNA sensitized CaSki cervical cancer cells to hydrogen peroxide-induced apoptosis with concurrent increase in Bax expression. Transient expression of E5 significantly increased the degradation rate of Bax protein by inducing the ubiquitination. The E5-induced decrease in Bax expression was in...
Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
Conclusions: Our data strongly indicate the high therapeutic potential of vorinostat in uterine sarcomas. (Source: Molecular Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Latest Advances In Minimally Invasive Medicine Featured At Society Of Interventional Radiology Meeting March 13-18 In Tampa, Fla.
The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13 -18 at the Tampa Convention Center. More than 5,000 physicians, scientists and allied health professionals are expected to attend this premier IR event... (Source: Health News from Medical News Today)
Latest Advances In Minimally Invasive Medicine Featured At Society Of Interventional Radiology Meeting March 13-18 In Tampa, Fla.
The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13 -18 at the Tampa Convention Center... (Source: Cancer / Oncology News From Medical News Today)
Dietary glycemic index and load in relation to risk of uterine leiomyomata in the Black Women's Health Study.
CONCLUSIONS: Our results suggest that high dietary GI and GL may be associated with an increased UL risk in some women. The observed associations warrant investigation in future studies. PMID: 20200259 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
Many signaling pathways that contribute to tumorigenesis are also functional in pregnancy, although they are dysregulated in the former and tightly regulated in the latter. Transformation-related protein 53 (Trp53), which encodes p53, is a tumor suppressor gene whose mutation is strongly associated with cancer. However, its role in normal physiological processes, including female reproduction, is poorly understood. Mice that have a constitutive deletion of Trp53 exhibit widespread development of carcinogenesis at early reproductive ages, compromised spermatogenesis, and fetal exencephaly, rendering them less amenable to studying the role of p53 in reproduction. To overcome this obstacle, we generated mice that harbor a conditional deletion of uterine Trp53 and examined pregnancy outcome in...
Society of Interventional Radiology hosts 35th Annual Scientific Meeting
(Society of Interventional Radiology) The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13-18 at the Tampa Convention Center. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
Conclusion: We hypothesise that prolonged and repeated UVB exposure selects for skin cells bearing stable FOXM1 protein causes aberrant cell cycle checkpoint thereby allowing ectopic cell cycle entry and subsequent genomic instability. The aberrant upregulation of FOXM1 serves as a first hit where cells acquire genomic instability which in turn predisposes cells to a second hit whereby DNA-damage checkpoint response (eg. p53 or p16) is abolished to allow damaged cells to proliferate and accumulate genetic aberrations/mutations required for cancer initiation. (Source: Molecular Cancer)
Removing Lymph Nodes May Boost Endometrial Cancer Survival
For medium- to high-risk women, more surgery is better, study shows Source: HealthDay Related MedlinePlus Pages: Lymphatic Diseases, Uterine Cancer (Source: MedlinePlus Health News)
Long-term endometrial effects in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES)--a randomised controlled trial of exemestane versus continued tamoxifen after 2-3 years tamoxifen
Conclusion: Switching from tamoxifen to exemestane significantly reverses endometrial thickening associated with continued tamoxifen. (Source: Annals of Oncology)
Faith makes regulating herbal medicine difficult
A judge this week called for traditional medicine to be regulated, but it's not easy when practitioners make claims based on faithYou may have read about Ying Wu this week: a traditional Chinese medicine doctor operating out of a shop in Chelmsford, Essex, who for several years prescribed pills with high doses of a dangerous substance to treat the acne of senior civil servant Patricia Booth, 58. Following this, her patient lost both kidneys, developed urinary tract cancer, had a heart attack, and is on dialysis three times a week. Judge Jeremy Roberts gave Ying a two-year conditional discharge, saying she could not be blamed, because she did not know the pills were harmful and the practice of traditional Chinese medicine is unregulated in Britain, a situation that he suggests should be rem...
Faith clouds herbal medicine regulation
A judge this week called for traditional medicine to be regulated, but it's not easy when practitioners make claims based on faithYou may have read about Ying Wu this week: a traditional Chinese medicine doctor operating out of a shop in Chelmsford, Essex, who for several years prescribed pills with high doses of a dangerous substance to treat the acne of senior civil servant Patricia Booth, 58. Following this, her patient lost both kidneys, developed urinary tract cancer, had a heart attack, and is on dialysis three times a week. Judge Jeremy Roberts gave Ying a two-year conditional discharge, saying she could not be blamed, because she did not know the pills were harmful and the practice of traditional Chinese medicine is unregulated in Britain, a situation that he suggests should be rem...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Assessment of Tumor Recurrence in Patients With Colorectal Cancer and Elevated Carcinoembryonic Antigen Level: FDG PET/CT Versus Contrast-Enhanced 64-MDCT of the Chest and Abdomen
CONCLUSION. FDG PET/CT has higher sensitivity than MDCT in the identification of sites of recurrent and metastatic disease in patients with colorectal cancer and an elevated CEA level. The two techniques appear to have similar specificity. (Source: American Journal of Roentgenology)
Study Findings On Cervical Cancer Are Outlined In Reports From University Of Michigan
In previous studies, we have shown a three to four times higher urban incidence of breast cancer and estrogen receptor-positive breast cancers in the Gharbiah Province of Egypt. We investigated the urban-rural incidence differences of gynaecologic malignancies (uterine, ovarian and cervical cancers) to explore if they show the same trend that we found for breast cancer, scientists in the United States report. (Source: Cancercompass News: Gynecological Cancer)
The influence of TXNDC5 gene on gastric cancer cell
Conclusion  TXNDC5 can promote the growth and proliferation of gastric cells. Silencing of TXNDC5 can restrain the growth and proliferation of gastric cancer cells. The gene can enhance the capability of invasion of gastric cancer cells. In some respects, TXNDC5 could be thought as a tumor-enhancing gene in gastric cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0807-xAuthors Lin Zhang, The 309 Hospital of PLA Department of Gastroenterology and Hepatology Beijing 100091 ChinaYanhong Hou, The 309 Hospital of PLA Department of Gastroenterology and Hepatology Beijing 100091 ChinaNan Li, The 309 Hospital of PLA Department of Gastroenterology and Hepatology Beijing 100091 ChinaKai Wu, The 309 Hospital of PLA Department of Gastroenterology a...
Tobacco Use Linked To Worse Outcomes In HPV-Positive Head And Neck Cancer, U-M Study Finds
Patients with head and neck cancer linked to high risk human papillomavirus, or HPV, have worse outcomes if they are current or former tobacco users, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center. High-risk HPVs are the same viruses that are associated with cancers of the uterine cervix... (Source: Cancer / Oncology News From Medical News Today)
Tobacco Use Linked To Worse Outcomes In HPV-Positive Head And Neck Cancer, U-M Study Finds
Patients with head and neck cancer linked to high risk human papillomavirus, or HPV, have worse outcomes if they are current or former tobacco users, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center. High-risk HPVs are the same viruses that are associated with cancers of the uterine cervix. The research suggests that current or former tobacco users may need a more aggressive treatment regimen than patients who have never used tobacco... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Transcription Factor KLF11 Integrates Progesterone Receptor Signaling and Proliferation in Uterine Leiomyoma Cells
Progesterone signaling is crucial for proliferation of a variety of clinically significant tumors in women, but compared to estrogen signaling relatively less is understood about the signaling pathways for progesterone. (Source: Cancer Research)
Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells.
Conclusion: The antitumor activity of Ad-miR122 was probably due to the induction of apoptosis and/or cell cycle arrest in cancer cells through inhibiting Bcl-W and/or CCNG1 expression. We concluded that expression of therapeutic microRNA, such as miR-122, via adenoviral vector is a promising strategy for cancer treatment. PMID: 20150764 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Do HLRCC and BHD Syndrome share a similar obligation to respire anaerobically?
Yang et al, (2010) describe the generation and characterisation of an immortalised hereditary leiomyomatosis renal cell carcinoma (HLRCC) cell line, derived from a human patient. HLRCC is a form of inherited kidney cancer in which affected individuals are at risk of developing cutaneous and uterine leiomyomas and kidney cancer, characterized by germline mutation of the Krebs cycle enzyme fumarate hydratase (FH; Launonen et al, 2001). Incidences of renal cancer in HLRCC are highly aggressive and often result in metastasis.02/14/2010 (Source: Kidney Cancer Association)
Leiomyoma of the gallbladder: a case report with review of the literature and discussion of the differential diagnosis
Mesenchymal neoplasms of the gallbladder are rare, and most represent sarcomas of various histological types. To our knowledge, only a few patients with multiple Epstein–Barr virus (EBV)-associated smooth muscle tumours of the gallbladder in the setting of immunodeficiency have been reported in the English literature, but no single case of conventional leiomyoma has been well documented to date. A case of gallbladder leiomyoma in a healthy 34-year-old woman is described here. The tumour was found incidentally on a routine ultrasound examination and was removed by simple cholecystectomy. The patient is alive and well at last follow-up, 6 months after surgery. Histology and immunohistochemistry were consistent with a benign smooth muscle neoplasm that is very similar to conventional ut...
Lymphoepithelioma-like carcinoma of the uterine cervix
We report a case of LELC of the cervix, diagnosed on the basis of histopathology in a 42-year-old female who presented with a history of postcoital bleeding. (Source: Journal of Cancer Research and Therapeutics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Incidence of malignancy in primary Sjogren's syndrome in a Chinese cohort
Conclusions. The current study confirms the increased incidence of lymphoma in Chinese patients with pSS, with the majority of B-cell non-Hodgkin’s lymphoma. Associations between pSS and other malignant tumours such as myeloid myeloma, mouth cancer, breast cancer and thymoma need to be further observed. (Source: Rheumatology)
High micronucleus frequency in peripheral blood lymphocytes of untreated cancer patients irrespective of gender, smoking and cancer sites.
In conclusion, untreated cancer patients may be associated with an increase of chromosomal instability in peripheral blood lymphocytes, irrespective of gender, cigarette smoking and cancer sites. PMID: 20139662 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Disparities in uterine cancer survival in a Brooklyn cohort of black women
Future Oncology , February 2010, Vol. 6, No. 2, Pages 319-327. (Source: Future Oncology)
Revealing A Potent Suppressor Of Endometrial Cancer
Endometrial cancer is the most common cancer of the female reproductive tract, representing 6% of all cancers. There is currently no screening method or biomarker to indicate early presence of disease. "It is a very common malignancy that affects women of all ages" comments paper author Dr. Diego Castrillon. The cancer forms from the cells that grow along the inner lining of the uterus, which is called the endometrium, and usually it is diagnosed following patient reports of abnormal bleeding... (Source: Health News from Medical News Today)
Phase I Trial of Pelvic Radiation, Weekly Cisplatin, and 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone (3-AP, NSC #663249) for Locally Advanced Cervical Cancer.
CONCLUSIONS: 3-AP was well tolerated at a three times weekly i.v. 25 mg/m(2) dose during cisplatin and pelvic radiation. Clin Cancer Res; 16(4); 1298-306. PMID: 20145183 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
A potent suppressor of endometrial cancer is revealed
(The Company of Biologists) Treatment of endometrial cancer has not advanced significantly in 30 years and there are no screening tests to promote early detection. Researchers at the University of Texas Southwestern Medical Center and Harvard Medical School developed a new approach to specifically target genetic changes to the endometrial cells in mice. Using this new technique, they show that loss of an emerging tumor suppressor causes abnormal growth and widespread malignancy of cells lining the uterus. (Source: EurekAlert! - Social and Behavioral Science)
A potent suppressor of endometrial cancer is revealed
Treatment of endometrial cancer has not advanced significantly in 30 years and there are no screening tests to promote early detection. Researchers have developed a new approach to specifically target genetic changes to the endometrial cells in mice. Using this new technique, they show that loss of an emerging tumor suppressor causes abnormal growth and widespread malignancy of cells lining the uterus. (Source: ScienceDaily Headlines)
Diabetes Mellitus Type 2 ? An Independent Risk Factor for Cancer?
Exp Clin Endocrinol Diabetes 2010; 118: 4-8DOI: 10.1055/s-0029-1243193AbstractEpidemiological findings have shown up to two-fold increases in the risks of cancers of the colorectum, breast, endometrium, kidney (renal cell tumours), liver and pancreas among diabetes patients. In the present review, we address the question whether, on the basis of these epidemiological observations, type 2 diabetes should be considered a specific and independent risk factor for these various forms of cancer, due to its particular metabolic characteristics of glucose intolerance and hyperinsulinemia. On the basis of further epidemiological evidence among non-diabetic individuals, as well as recent studies examining the effects of different types of diabetes treatment on cancer risks, we conclude that chronic ...
Vaginal polyp: an unusual cause of postmenopausal bleeding
We present this unusual case of fibroepithelial polyp of the vagina as a cause for PMB. Vaginal fibroepithelial polyp is a rare lesion, and although benign, it can be confused with malignant connective tissue lesions. Treatment is simple excision, and recurrence is extremely uncommon. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10397-010-0554-7Authors Janaki Putran, Colchester Hospital University NHS Foundation Trust Department of Obstetrics and Gynaecology Turner Road Colchester CO4 5JL UKRachana Gupta, Colchester Hospital University NHS Foundation Trust Department of Obstetrics and Gynaecology Turner Road Colchester CO4 5JL UK Journal Gynecological SurgeryOnline ISSN 1613-2084Print ISSN 1613-2076 (Source: Gynecological Surgery)
Research From University Hospital In Cervical Cancer Provides New Insights
Current study results from the report, 'Diagnostic approach for precancerous and early invasive cancerous lesions of the uterine cervix,' have been published. (Source: Cancercompass News: Gynecological Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Total laparoscopic hysterectomy with pelvic/aortic lymph node dissection for endometrial cancer-a consecutive series without case selection and comparison to laparotomy.
CONCLUSIONS: For clinically localized endometrial cancer, TLH/BSO/LND can functionally duplicate operative time equivalent to "open" procedures, while improving nodal yield, and minimizing influence of BMI on conversion to laparotomy and case selection. PMID: 20138346 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Fine Tuning of Endometrial Function by Estrogen and Progesterone Through microRNAs.
Authors: Lessey BA Progesterone suppresses estrogen at multiple levels in the normal secretory phase endometrium including the induction of microRNAs. If progesterone-stimulated miRNAs are disrupted, expression from the mRNA targets of each miRNA may fail to be suppressed, allowing excessive cell proliferation. In fact, recent work by others is already confirming the hypothesis that miRNAs are diagnostic smoking guns for various diseases like endometriosis. This is an area of intense investigation and one that is worth watching, especially for those interested in the endometrium, infertility, cancer, and even contraception. The study published in Biology of Reproduction by Kuokkanen et al. on miRNA expression in endometrial epithelium sets the stage to look for miRNAs as a mechanism fo...
Molecular alterations in uterine serous carcinoma.
CONCLUSIONS: Since optimal treatment of uterine serous carcinoma remains unknown, novel therapeutic approaches need to be actively pursued. The molecular targets discussed warrant further investigation and suggest a potential role for therapeutic agents targeting HER-2 and EGFR, as well as downstream targets such as the PI3K-AKT-mTOR pathway in the treatment of uterine serous carcinoma. PMID: 20109727 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Intractable haematuria: long-term results after selective embolization of the internal iliac arteries
Study Type [ndash] Therapy (case series)Level of Evidence 4 To determine the feasibility and efficacy of transarterial embolization (TAE) in haemorrhagic urological emergencies, and to assess the perioperative morbidity, effect of timing of intervention on the requirement for blood transfusion, and the long-term follow-up. Between October 1997 and March 2009, 44 patients (30 men and 14 women; mean age 79 years, range 51[ndash]95) with intractable haematuria secondary to advanced pelvic tumour arising from or invading the bladder, underwent internal iliac TAE. Twenty-four patients had transitional carcinoma of the urinary bladder, 12 adenocarcinoma of the prostate, five carcinoma of the uterus, one cancer of the vagina, two carcinoma of the rectum, three carcinoma of the kidney, two simulta...
Pomegranate Extract Stimulates Uterine Contractions
The team identified beta-sitosterol - a steroid that can inhibit the absorption of cholesterol in the intestine - as the main constituent of pomegranate seed extract. The research suggests that pomegranate extract could be used as a natural stimulant to encourage the uterus to contract during labour. Pomegranate juice is thought to have a number of health benefits, from lowering cholesterol and blood pressure to protecting against some cancers, but until now there has been no evidence to demonstrate its effects on the uterus... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Expression of interleukin-1 (IL-1) ligands system in the most common endometriosis-associated ovarian cancer subtypes
Conclusion: Endometrioid ovarian cancer exhibits an alteration in the expression of IL-1RA, a key protector against tumorogenic effects of IL-1. This alteration evokes the same alteration observed in endometriotic cells in previous studies. This suggests a possible link between the endometrium, the tissue ectopic endometriosis and endometrioid ovarian cancer. (Source: Journal of Ovarian Research)
Role of Progesterone in Endometrial Cancer
Semin Reprod Med 2010; 28: 081-090DOI: 10.1055/s-0029-1242998ABSTRACTProgesterone is a key hormone in the endometrium that opposes estrogen-driven growth. Insufficient progesterone will result in unopposed estrogen action that could lead to the development of endometrial hyperplasia and adenocarcinoma. Although these endometrial neoplasias can regress in response to progestin treatment, this does not occur in all instances. To understand this resistance to progesterone and to improve on existing hormonal therapies, it is imperative that the molecular mechanisms of progesterone action through its receptor be deciphered in endometrial cancer. This review highlights what is known thus far regarding the efficacy of progestin therapy in the clinic and the role of progesterone in endometrial can...
Novel chemoembolization using calcium-phosphate ceramic microsphere incorporating TNP-470, an anti-angiogenic agent
The purpose of the present study was to develop a new method of chemoembolization to improve the therapeutic effectiveness and safety profile of cancer treatment. A chemoembolization approach was designed for human solid tumors using resorbable calcium-phosphate ceramic microspheres loaded with an agent anti-angiogenic to tumor vasculature in vivo. The human uterine sarcoma cell line FU-MMT-3 was used in this study because this tumor is aggressive and also exhibits a poor response to radiotherapy or any chemotherapy currently used. The calcium-phosphate ceramic microspheres loaded with TNP-470, an anti-angiogenic agent, were injected into FU-MMT-3 xenografts in nude mice three times per week for 8 weeks. The treatment using TNP-470-loaded microspheres suppressed tumor growth, compared to t...
Primary surgery versus primary radiation therapy with or without chemotherapy for early adenocarcinoma of the uterine cervix
The objectives of this review were to compare the effectiveness and safety of primary surgery for early stage AC of the uterine cervix with primary radiotherapy or chemoradiation.   Search strategy We searched Cochrane Central Register of Controlled Trials (CENTRAL) Issue 3, 2009, MEDLINE (1950 to July week 5, 2009), EMBASE (1980 to week 32, 2009) and we also searched the related articles feature of PubMed and the Web of Science. We also checked the reference lists of articles.   Selection ... (Source: NeLM - Oncology)
Endometrial Profile of Tamoxifen and Low-Dose Estradiol Combination Therapy.
CONCLUSIONS: These findings characterize a novel phenotype resulting from estrogen + SERM co-therapy. The predominance of Tam effects on endometrial proliferation, morphology, and transcriptional profiles suggests that endometrial risks for E(2) + Tam may be similar to Tam alone. Clin Cancer Res; 16(3); 946-56. PMID: 20103679 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
[Cervical screening: Toward a new paradigm?]
CONCLUSION: The health care providers in France have to understand the characteristics of the HPV testing: its advantages compared to the cytologic screening are only evident in case of an organization of the screening in France and even in Europe. PMID: 20106606 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)
Rapid, Sensitive Type Specific PCR Detection of the E6 and E7 regions of Human Papillomavirus Type 16 and 18 from Paraffin Embedded Sections of Cervical Carcinoma
Human papillomavirus (HPV) infection, and in particularly infection with HPVs 16 and 18 is a central carcinogenic factor in the uterine cervix. We established and optimized a PCR assay for the detection and discrimination of HPV types 16 and 18 in archival formaldehyde fixed and paraffin embedded (FFPE) sections of cervical cancer.Tissue blocks from 35 cases of in situ or invasive cervical squamouscell carcinoma and surrogate FFPE sections containing the cell lines HeLa and SiHa were tested for HPV 16 and HPV18 and for the housekeeping gene beta-actin by conventional PCR using type specific primers. Using HPV 16 E7 primers, PCR products with the expected length were detected in 18 of 35 of FFPE sections (51%). HPV 18 E7 specific sequences were detected in 3 of 35 FFPE sections (9%).In our ...
Ultrastaging of lymph node in uterine cancers
Conclusion: In uterine cancers, H&E, serial sectioning and IHC appears the best histological combined technique to detect micrometastases. Although accumulating data have proved the relation between the risk of recurrence and the presence of micrometastases, their clinical implications on indications for adjuvant therapy has to be clarified. (Source: Journal of Experimental and Clinical Cancer Research)
Novel Hydroxysteroid (17{beta}) Dehydrogenase 1 Inhibitors Reverse Estrogen-Induced Endometrial Hyperplasia in Transgenic Mice.
Authors: Saloniemi T, Järvensivu P, Koskimies P, Jokela H, Lamminen T, Ghaem-Maghami S, Dina R, Damdimopoulou P, Mäkelä S, Perheentupa A, Kujari H, Brosens J, Poutanen M Local estrogen production plays a key role in proliferative endometrial disorders, such as endometrial hyperplasia and cancer. Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion of weakly active estrone into highly potent estradiol. Here we report that female transgenic mice expressing human HSD17B1 invariably develop endometrial hyperplasia in adulthood. These mice also fail to ovulate and have enhanced peripheral conversion of estrone into estradiol in a variety of target tissues, including the uterus. As in humans, endometrial hyperplasia ...
A cancer stem cell origin for human endometrial carcinoma?
Authors: Hubbard S, Gargett C Endometrial cancer (EC) is the most common gynaecological malignancy affecting women in the Western world. Cancer stem cells (CSCs) are defined as a subset of tumour cells with the capacity to self renew and give rise to the differentiated cells that comprise the bulk of the tumour. Given that a rare population of epithelial stem/progenitor cells has been identified in human endometrium, it is possible that these or their progeny may be the source of the putative cancer stem cell that may initiate and maintain EC. Studies have shown that some cells within EC have the capacity to initiate clones that undergo self renewing cell division and form tumours in vivo that can be serially passaged, demonstrating self renewal, proliferation and differentiation abili...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases
Conclusion: The present endometriosis model would be useful for investigation of the mechanisms of angiogenesis process involved in the peritoneal attachment of endometrial cells, as well as of the effects of therapeutic drugs, particularly with antiangiogenic activity. (Source: Journal of Experimental and Clinical Cancer Research)
Cochrane review: Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Adjuvant tamoxifen reduces the risk of breast cancer recurrence in women with estrogen receptor-positive breast cancer. Tamoxifen also increases the risk of postmenopausal bleeding, endometrial hyperplasia, polyps, and endometrial cancer. The levonorgestrel-releasing intrauterine system (LNG-IUS) causes profound endometrial suppression. This systematic review considered the evidence that the LNG-IUS prevents the development of endometrial pathology in women taking tamoxifen as adjuvant endocrine therapy for breast cancer.   Objectives To determine the effectiveness of the levonorgestrel intrauterine system in preventing the development of endometrial hyperplasia, polyps, and adenocarcinoma in pre and post...
Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy
Conclusion  Amputation of uterine corpus during CRH for invasive cervical cancer during pregnancy significantly improves the intraoperative performance, although it should be used with care. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0014-4Authors Koji Matsuo, MD Anderson Cancer Center, University of Texas Department of Gynecologic Oncology, Unit 1362 1151 Pressler Street P.O. Box 301439 Houston TX 77230-1439 USATakayuki Enomoto, Osaka University Graduate School of Medicine Department of Obstetrics and Gynecology Osaka JapanMasato Yamasaki, Osaka Rosai Hospital Department of Obstetrics and Gynecology Osaka Japan Journal International Journal of Clinical OncologyOnline ISSN 1437-7772Print ISSN 1341-9625 (Source: International Journ...
Heterozygous deficiency of {delta}-catenin impairs pathological angiogenesis
Vascular and neuronal networks share a similar branching morphology, and emerging evidence implicates common mechanisms in the formation of both systems. -Catenin is considered a neuronal catenin regulating neuron cell–cell adhesion and cell motility. Here, we report expression of -catenin in vascular endothelium, and show that deletion of only one allele of -catenin is sufficient to impair endothelial cell motility and vascular assembly in vitro and pathological angiogenesis in vivo, thereby inhibiting tumor growth and wound healing. In contrast, deletion of one or both allele of -catenin had no effects on hormone-induced physiological angiogenesis in the uterus. Molecular analysis confirmed a gene dosage effect of -catenin on Rho GTPase activity. Moreover, we show that inflammatory...
Endometrial Cancer: Often Curable When Caught Early
Postmenopausal women who experience vaginal bleeding should see a doctor promptly. According to the January issue of Mayo Clinic Health Letter, vaginal bleeding is a symptom that occurs early in the course of endometrial cancer, when the chance of a complete cure is the greatest. Even one drop of blood is abnormal in postmenopausal women. The endometrium is the inner lining of the uterus... (Source: Cancer / Oncology News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Endometrial Cancer: Often Curable When Caught Early
Postmenopausal women who experience vaginal bleeding should see a doctor promptly. According to the January issue of Mayo Clinic Health Letter, vaginal bleeding is a symptom that occurs early in the course of endometrial cancer, when the chance of a complete cure is the greatest. Even one drop of blood is abnormal in postmenopausal women. The endometrium is the inner lining of the uterus. Endometrial cancer develops when cells divide and grow abnormally, potentially invading other layers of the uterine tissue or even spreading beyond the uterus... (Source: Health News from Medical News Today)
Researchers Report Details Of New Studies For Endometrial Cancer Immunology
Investigators publish new data in the report 'p53 overexpression in morphologically ambiguous endometrial carcinomas correlates with adverse clinical outcomes.' According to a study from the United States, The distinction between uterine serous and endometrioid carcinomas can usually be achieved by morphologic examination alone. (Source: Cancercompass News: Other Cancer)
Myocardin Functions as an Effective Inducer of Growth Arrest and Differentiation in Human Uterine Leiomyosarcoma Cells
An unusual mechanism of cell cycle deregulation is revealed in uterine leiomyosarcomas, which along with endometrial tumors are the two most common uterine tumors encountered clinically. (Source: Cancer Research)
Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding.
This study explores how RCAS1 is involved in apoptosis initiation. The cell lines SiSo and MCF-7, human uterine carcinoma and breast adenocarcinoma, respectively, both express RCAS1, but RCAS1 secretion is undetectable in MCF-7 cells. SiSo and MCF-7 cells were stimulated to induce RCAS1 ectodomain shedding followed by assessment of RCAS1 expression and secretion. Additionally, the RCAS1 putative receptor-expressing human chronic myelogenous leukemia cell line K562 was co-cultured with SiSo, MCF-7, or soluble RCAS1 to follow RCAS1 secretion in apoptosis initiation. RCAS1 secretion was strongly suppressed by inhibitors of metalloproteases, protein kinase C (PKC)-delta, mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase (MEK), epidermal growth factor (EGF), a...
Anti-breast cancer potential of SS1020, a novel antiestrogen lacking estrogenic and genotoxic actions
Long-term treatment with tamoxifen (TAM) increases the risk of developing endometrial cancer in women. Several antiestrogens developed in last decades have been discontinued from clinical testing because of their undesirable effects on the uterus. To avoid such serious side-effect while increasing the drug's anti-breast cancer potential, new triphenylethylene antiestrogens, 2E-3-{4-[(E)-4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]-phenyl} acrylic acid (SS1020) and 2E-3-{4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenyl}acrylic acid (SS1010), were designed as safer alternatives. Unlike TAM, SS1020 does not present significant uterotrophic potential in rats; in contrast, SS1010, a compound removing a 4-OH moiety from SS1020, represented weak uterotrophic activity. The structurally related co...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Myocardin Functions as an Effective Inducer of Growth Arrest and Differentiation in Human Uterine Leiomyosarcoma Cells.
Authors: Kimura Y, Morita T, Hayashi K, Miki T, Sobue K Myocardin is an important transcriptional regulator in smooth and cardiac muscle development. We noticed that the expression of myocardin was markedly downregulated in human uterine leiomyosarcoma cells. Restoration of myocardin expression induced the reexpression of smooth muscle marker proteins and the formation of well-developed actin fibers. A concomitant increase in the expression of a cyclin-dependent kinase inhibitor, p21, led to significantly reduced cell proliferation, via p21's inhibition of the G(1)-S transition. A p21 promoter-reporter assay showed that myocardin markedly increased p21's promoter activity. Furthermore, a serum response factor (SRF)-binding cis-element CArG box in the p21 promoter region was required fo...
Mary Kay Foundation Grant Application Announcement for Innovative/Translational Cancer Research
Applications are accepted from November 1, 2009, through February 12, 2010Deadline For Receipt: Friday, February 12, 2010. Applications must be received no later than 5 p.m., CST. Faxes will not be accepted.Applications should be sent to:The Mary Kay FoundationP. O. Box 799044Dallas, TX 75379-9044(877) 652-2737Federal Express applications should be sent to:The Mary Kay Foundation16251 Dallas ParkwayAddison, TX 75001Innovative / Translational Cancer ResearchThe Mary Kay Foundation, a funding source for cancer research, is currently accepting applications for innovative grants for translational research in ovarian, uterine, breast, or cervical cancer.The program will offer at least eight grants. The awards will be up to $100,000 each (combined direct and indirect costs). The grant period is...
[Case Report] Cutaneous papules, uterine fibroids, and renal cell cancer: one family's tale
In May, 2007, a 35-year-old woman was referred to our dermatology unit with painful papules and nodules on the left side of her body. The lesions had developed on her left arm at the age of 14 years and subsequently appeared on her left leg, buttocks, and back. Pain at these sites was episodic and aggravated on exposure to cold. More recently, her lesions had progressed and become more painful. Medical history included a subtotal hysterectomy at age 25 years for menorrhagia from uterine leiomyomas. She had a 47-year-old female first cousin with a history of similar skin lesions on her legs since age 34 years, a total hysterectomy for uterine leiomyomas at 44 years, and a right mastectomy for breast cancer at 45 years. Her brother, at age 23 years, had a right total nephrectomy for renal ce...
The global burden of cancer: priorities for prevention
Despite decreases in the cancer death rates in high-resource countries, such as the USA, the number of cancer cases and deaths is projected to more than double worldwide over the next 20–40 years. Cancer is now the third leading cause of death, with >12 million new cases and 7.6 million cancer deaths estimated to have occurred globally in 2007 (1). By 2030, it is projected that there will be ~26 million new cancer cases and 17 million cancer deaths per year. The projected increase will be driven largely by growth and aging of populations and will be largest in low- and medium-resource countries. Under current trends, increased longevity in developing countries will nearly triple the number of people who survive to age 65 by 2050. This demographic shift is compounded by the entrenc...
Radio Frequency Energy Used To Shrink Fibroids And Reduce Symptoms In New Minimally Invasive Procedure
Montefiore Medical Center recently became the only hospital on the East Coast to conduct the Radio Frequency Ablation procedure to shrink uterine fibroids in women 30 years and older. This minimally invasive procedure, initially used to treat liver cancer, uses a tiny needle that is inserted into the fibroid, applying low energy radio frequency electrical current, which creates localized tumor destruction by heat... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Socioeconomic inequalities in cancer incidence and mortality?a spatial analysis in Bremen, Germany
Conclusions  In spite of the methodical restrictions, our analyses suggest an association between social factors and cancer incidence and mortality. The results are in agreement with international studies. Many of the observed social class differences could probably be explained by known risk factors, such as smoking, alcohol consumption, diet and physical activity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10389-009-0306-1Authors Andrea Eberle, University of Bremen Bremen Institute for Prevention Research and Social Medicine Linzer Str. 10 28359 Bremen GermanySabine Luttmann, University of Bremen Bremen Institute for Prevention Research and Social Medicine Linzer Str. 10 28359 Bremen GermanyRonja Foraita, University of Bremen Bremen Institute f...
Blood sugar and cancer risk
Conclusion This large prospective cohort study was well conducted. However, there are several facts that should be considered when interpreting the results. The study included previous smokers. Although the researchers say that smoking status had no effect on their findings, they also state that imprecise or incorrect categorisation of smoking status may have affected the results. The researchers highlight that the different protocols for measuring blood glucose levels may have affected the outcome. Information about the participants? diet and lifestyle was not available, for example exercise levels, alcohol consumption or the many other genetic and medical risk factors that can also contribute to the risk of cancer. The 5 and 11% risk increases for men and women had only bor...
Ten million Britons at risk from cancer, reveals new research
This study looked at the link between high blood glucose levels such as those found in people with pre-diabetes and the relative risk of both getting cancer and dying from it. It is important, however, not to oversimplify the findings of this study. It would be wrong to conclude that high blood glucose levels alone are causing the increase in cancer cases and deaths. Nor can we say that, by controlling blood glucose levels alone, we could lower the risk of cancer. There are likely to be other factors at work, such as genetics, diet and levels of physical activity, which are all also linked to both cancer and blood glucose levels," said Frame.People could reduce their risk of developing either pre-diabetes or Type 2 diabetes by being more physically active and eating plenty of fruit and veg...
Excess blood sugar raises cancer risk
This study looked at the link between high blood glucose levels such as those found in people with pre-diabetes and the relative risk of both getting cancer and dying from it. It is important, however, not to oversimplify the findings of this study. It would be wrong to conclude that high blood glucose levels alone are causing the increase in cancer cases and deaths. Nor can we say that, by controlling blood glucose levels alone, we could lower the risk of cancer. There are likely to be other factors at work, such as genetics, diet and levels of physical activity, which are all also linked to both cancer and blood glucose levels," said Frame.People could reduce their risk of developing either pre-diabetes or Type 2 diabetes by being more physically active and eating plenty of fruit and veg...
Expression of fibroblast growth factor receptor 2 IIIc in human uterine cervical intraepithelial neoplasia and cervical cancer.
In this study, we determined the expression and roles of FGFR2 IIIc in cervical intraepithelial neoplasia (CIN) and cervical cancer. In CINs 1 and 2, FGFR2 IIIc was found to be localized at the basal to lower two-thirds of the squamous epithelium, whereas it was localized in most of the squamous epithelium, except for the superficial layer in CIN 3. In situ hybridization (ISH) analysis showed that the expression patterns of FGFR2 IIIc mRNA are similar to those of FGFR2 IIIc protein in CINs. The FGFR2 IIIc protein was detected in all invasive cervical cancer patients (29 cases) and its mRNA was found to be strongly expressed in the invasive front of cancer cell nests. FGFR2 IIIc cDNA was stably transfected into CaSki cells, which are derived from a cervical SCC. The growth rates of the CaSk...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Laparoscopic Nerve-Sparing Radical Trachelectomy: Surgical Technique and Outcome
Conclusions: Laparoscopic nerve-sparring radical trachelectomy may be an alternative in fertility-preserving surgery for cervical cancer in centers in which specialization in radical vaginal surgery is lacking. The procedure enables preservation of autonomic innervation of the urinary bladder and the arterial supply of the uterus. (Source: The Journal of Minimally Invasive Gynecology)
Laparoscopic Pelvic Lymphadenectomy in a Patient with Cervical Cancer Stage Ib1 Complicated by a Twin Pregnancy
Abstract: Cervical cancer is the most frequently observed malignancy during pregnancy. The presence of nodal metastasis is the most important negative predictor factor, and its assessment is crucial in deciding whether the pregnancy can safely continue. To our knowledge, this is the first report of a twin pregnancy complicated by cancer of the uterine cervix that was sucessfully treated with laparoscopic pelvic lymphadenectomy and subsequently with neoadjuvant chemotherapy. A 35-year-old woman, gravida 2, para 1, with a dichorionic-diamniotic twin pregnancy underwent laparoscopic staging of the pelvic lymph nodes at 17 weeks of gestation. Cervical adenocarcinoma, grade 2, stage 1b1 with lymphovascular space invasion was diagnosed. Nineteen negative nodes were removed, and the patient was c...
NewsCap: Younger women with early-stage ovarian cancer can keep the healthy ovary and uterus
No abstract available (Source: AJN)
The prevalence of benign and malignant neoplasms in acromegalic patients.
Conclusions: From our retrospective study, we suggest an overall increase of tumour incidence in acromegalic patients. Prospective multicentre studies are required to resolve the significance of this observation. In our study group, the number of malignant neoplasms was significantly higher in patients with long-lasting uncontrolled disease (over 5 years), compared to patients with controlled disease. (Pol J Endocrinol 2010; 61 (1): 29-34). PMID: 20205101 [PubMed - in process] (Source: Endokrynologia Polska)
Comparison of Time Trends in Uterus Cancer and Cervix Uteri Cancer Mortality (1990-2006) in the World, from the WHO Mortality Database
(Source: Japanese Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
An Exploration of Shared Genetic Risk Factors Between Periodontal Disease and Cancers: A Prospective Co-Twin Study
Biologic mechanisms underlying associations of periodontal disease with cancers remain unknown. The authors propose that both conditions share common genetic risk factors. They analyzed associations between baseline periodontal disease, measured by questionnaire-recorded tooth mobility, and incident cancers, identified by linkage with national registries, between 1963 and 2004 in 15,333 Swedish twins. The authors used co-twin analyses to control for familial factors and undertook analyses restricted to monozygotic twins to further control for confounding by genetic factors. They observed 4,361 cancer cases over 548,913 person-years. After adjustment for covariates, baseline periodontal disease was associated with increased risk of several cancers ranging from 15% for total cancer (proporti...
Transcriptional regulation of pro-apoptotic Par-4 by NF-[kappa]B/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis
Prostatic apoptosis response-4 (Par-4) was first identified in prostatic cancer cells that were induced to undergo apoptosis. Recently, Par-4 has been suggested to be a tumour suppressor gene that plays a role in the development of endometrial carcinomas (ECs), but the exact mechanism remains to be clarified. Here we examined gene activation signalling cascades and influence on cell kinetics during endometrial tumourigenesis. In normal endometrium, constitutively high levels of Par-4 expression were observed in epithelial cells through the menstrual cycle, in contrast to the transient up-regulation in stromal components in the menstrual stage, correlated positively with the phospho-p65 (pp65) status and apoptosis. In contrast, most ECs exhibited significant down-regulation as compared to n...
Phase II Study of Carboplatin, Paclitaxel, and Bevacizumab With Maintenance Bevacizumab As First-Line Chemotherapy for Advanced Mullerian Tumors [Gynecologic Cancer]
Conclusion The regimen of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab is feasible, safe, and worthy of future study in advanced ovarian cancer. (Source: Journal of Clinical Oncology)
An Alternative Interpretation of, "A Lifetime Cancer Bioassay of Quinacrine Administered into the Uterine Horns of Female Rats"
Authors: McConnell EE, Lippes J, Growe RG, Fail P, Luster MI, Zeiger E This companion article offers an alternative interpretation for the quinacrine-induced uterine tumors observed in a 2-year bioassay in rats (CaBio, Cancel et al., this issue), and provides additional data from two new experiments that support a different interpretation and analysis. Our major premise is that the design of the Cancel et al. bioassay was flawed, particularly regarding dose selection that allowed for misinterpretation of carcinogenic activity. We feel the totality of the information provided herein dictates that the doses (70/70, 70/250 and 70/350 mg/kg quinacrine) causing uterine tumors in their study clearly exceeded the maximum tolerated dose (MTD) typically administered in chronic cancer studies. O...
NewsCap: Younger women with early-stage ovarian cancer can keep the healthy ovary and uterus.
Authors: PMID: 20032655 [PubMed - in process] (Source: The American Journal of Nursing)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
BJOG Release: Study Finds Higher Incidence Of Gynaecological Cancers In Urban Areas
New research to be published in BJOG: An International Journal of Obstetrics and Gynaecology has found a higher incidence of gynaecological cancers (uterine, ovarian and cervical cancer) in urban areas of Egypt, as compared to rural areas. The incidence of uterine cancer among urban women was six times higher than that of rural women. The study suggests that women in urban areas may have a higher exposure to environmental xenoestrogens (industrially made compounds that have an oestrogenic activity), which may increase the risk of developing hormone-related cancers... (Source: Health News from Medical News Today)
BJOG Release: Study Finds Higher Incidence Of Gynaecological Cancers In Urban Areas
New research to be published in BJOG: An International Journal of Obstetrics and Gynaecology has found a higher incidence of gynaecological cancers (uterine, ovarian and cervical cancer) in urban areas of Egypt, as compared to rural areas. The incidence of uterine cancer among urban women was six times higher than that of rural women... (Source: Cancer / Oncology News From Medical News Today)
BJOG Release: Study Finds Higher Incidence Of Gynaecological Cancers In Urban Areas
New research to be published in BJOG: An International Journal of Obstetrics and Gynaecology has found a higher incidence of gynaecological cancers (uterine, ovarian and cervical cancer) in urban areas of Egypt, as compared to rural areas. The incidence of uterine cancer among urban women was six times higher than that of rural women... (Source: Women's Health / OBGYN News From Medical News Today)
Lymph node dissection in the surgical management of atypical endometrial hyperplasia
Conclusion: Lymph node dissection did not adversely affect surgical outcomes in patients with atypical endometrial hyperplasia. Because many of these patients have concurrent endometrial cancer, we recommend consideration of lymph node dissection in atypical endometrial hyperplasia patients undergoing definitive surgical treatment. (Source: American Journal of Obstetrics and Gynecology)
Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology
Conclusion: An endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of CAH is more likely to correlate with final posthysterectomy grade than a diagnosis not arising with a background of CAH. (Source: American Journal of Obstetrics and Gynecology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome
Abstract  Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a tumor predisposition syndrome caused by heterozygous germline mutations in the fumarate hydratase (FH) gene. Cutaneous and uterine leiomyomas are the most common clinical manifestations of HLRCC, whereas only approximately 20% of the families display renal cell cancer (RCC). The number of RCC cases in these families varies from one to five. Interestingly, families with multiple RCC cases are mainly found in Finland and the USA. Such aggregation of RCC in only some families and populations has led to the hypothesis that besides FH mutations also other inherited genetic and/or environmental factors may contribute to the malignant kidney tumor formation. To search for such a genetic modifier we have performe...
Clinical characteristics and outcomes of women with stage IV endometrial cancer
Abstract  Treatment strategies for patients with stage IV endometrial cancer (EC) remain controversial. Some studies have suggested that optimal cytoreduction improves survival. We retrospectively analyzed the clinical characteristics and outcomes of 41 women with stage IV EC. The results of preoperative cytologic evaluation and biopsy of the endometrium were reviewed by a single pathologist for patients in whom stage IV EC was diagnosed preoperatively. Of the 41 patients with stage IV EC (median age, 62 years), 31 had surgical stage IV disease and 10 had clinical stage IV disease. Twenty-eight patients were diagnosed of stage IV EC before surgery or without surgery. Progression-free survival and overall survival were 10.4 and 21.3 months, respectively. On univari...
Methods of Cancer Diagnosis, Therapy, and Prognosis
Ovarian Cancer, Renal Cancer, Urogenitary tract Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma series: Methods of Cancer Diagnosis, Therapy and Prognosis This sixth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses Ovarian Cancer, Renal Cancer, Urogenitary Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma. Both standard and emerging therapies for these cancers, written by expert oncologists/pathologists in this field, are included.This fully ... (Source: Springer Biomedical Sciences titles)
Insular thyroid carcinoma in a patient with Cowden syndrome
We present a patient with clinically relevant manifestations of Cowden syndrome, with genetic verification, impacting by way of airway compromise due to hamartomas, urinary tract abnormalities, and insular thyroid cancer. This case illustrates the value of recognizing Cowden syndrome at an earlier stage when the patient could have received appropriate management to decrease the morbidity of untreated hamartomatous growths, and an elective thyroidectomy would have been a viable option to manage his malignancy. Through this case report, we provide further insight into management of this disorder. Laryngoscope, 2010 (Source: The Laryngoscope)
A taxonomy of epithelial human cancer and their metastases
Conclusion: Our molecular taxonomy of epithelial human cancer indicates surprising correlations over tissues. This may have a significant impact on the classification of many cancer sites and may guide pathologists, both in research and daily practice. Moreover, these results based on unsupervised analysis yielded a signature predictive of clinical outcome in breast cancer. Additionally, we hypothesize that metastases from gastrointestinal origin either remember their tissue of origin or adapt to the tissue of destination. More specifically, colon metastases in the liver show strong evidence for such a bimodal tissue specific profile. (Source: BMC Medical Genomics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma.
Conclusions: Our results indicate that the HER2 655Val variant may be associated with the incidence of advanced cervical cancer. PMID: 20026098 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1
The hereditary colon and endometrium cancer predisposition Lynch Syndrome (also called HNPCC) is caused by a germ-line mutation in one of the DNA mismatch repair (MMR) genes. A significant fraction of the gene alterations detected in suspected Lynch Syndrome patients is comprised of amino acid substitutions. The relevance for cancer risk of these variants is difficult to assess, as currently no time- and cost-effective, validated, and widely applicable functional assays for the measurement of MMR activity are available. Here we describe a rapid, cell-free, and easily quantifiable MMR activity assay for the diagnostic assessment of variants of the MLH1 MMR protein. This assay allows the parallel generation and functional analysis of a series of variants of the MLH1 protein in vitro using re...
Loss of let-7 binding sites resulting from truncations of the 3? untranslated region of HMGA2 mRNA in uterine leiomyomas
Abstract: A subset of uterine leiomyomas (UL) shows chromosomal rearrangements of the region 12q14?q15, leading to an overexpression of the high-mobility group protein A2 gene (HMGA2). Recent studies identified microRNAs of the let-7 family as post-transcriptional regulators of HMGA2. Intragenic chromosomal breakpoints might cause truncated HMGA2 transcripts lacking part of the 3' UTR. The corresponding loss of let-7 complementary sites (LCS) located in the 3' UTR would therefore stabilize HMGA2 mRNA. The aim of this study was to check UL with rearrangements of the chromosomal region 12q14?15 for truncated HMGA2 transcripts by real-time reverse-transcription polymerase chain reaction. In 8/13 leiomyomas with aberrations of chromosomal region 12q15, the results showed the presence of th...
Temporal and Spatial Expression of Tumor-Associated Antigen RCAS1 in Pregnant Mouse Uterus
Conclusion The results of this study suggest the importance of day 7.5 p.c. for RCAS1 protein expression in connection with placentation as a possible target for future in vivo studies. (Source: American Journal of Reproductive Immunology)
Urban–rural differences of gynaecological malignancies in Egypt (1999–2002)
Conclusions The higher urban incidence of uterine cancer, coupled with our previous findings of higher incidence of breast cancer and estrogen receptor positive breast cancer in urban areas in this region, may be suggestive of possible higher exposure to environmental estrogenic compounds, such as xenoestrogens, in urban areas. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Gynaecological cancers more common in urban areas
Study finds six times higher incidence of uterine cancer in urban areasRelated items from OnMedicaPolycystic ovarian syndromeWomen are taking risks for overseas fertility treatmentDoctors are missing symptoms of ovarian cancerFast treatment for auto-immune brain condition Alert on antibiotics during pregnancy issued (Source: OnMedica Latest News)
Urban-rural differences of gynaecological malignancies in Egypt (1999-2002).
Conclusions The higher urban incidence of uterine cancer, coupled with our previous findings of higher incidence of breast cancer and estrogen receptor positive breast cancer in urban areas in this region, may be suggestive of possible higher exposure to environmental estrogenic compounds, such as xenoestrogens, in urban areas. PMID: 20015310 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
ERBB Receptor Feedback Inhibitor 1 Regulation of Estrogen Receptor Activity Is Critical for Uterine Implantation in Mice.
Authors: Kim TH, Lee DK, Franco HL, Lydon JP, Jeong JW Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. E2 acts to stimulate the proliferation of uterine epithelial cells while P4 action inhibits E2-mediated proliferation of the epithelium. P4 through its cognate receptor, the progesterone receptor (Pgr), has important roles in the establishment and maintenance of pregnancy. In previous studies, we have identified ERBB receptor feedback inhibitor 1 (Errfi1) as a downstream target of Pgr action in the uterus. Here we show that Errfi1 mRNA expression was significantly increased in the uterus after day 2.5 of gestation. Its expression is also induced in the uterus by acute E2 treatment and this induction is synergistically induced by chronic E...
Gonadotropins, clomifene may carry risk of uterine cancer
(Source: Reactions)
Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
Conclusions: This study exposes significant lack of phylogenetic and functional homology between human and murine AKR1C enzymes. Therefore, we conclude that mice are not suitable to model the role of AKR1C in human cancers and leukemia. (Source: Molecular Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Claudia Cohen Research Foundation Annual Prize for Outstanding Gynecologic Cancer Researcher
This $50,000 annual prize will be awarded to an individual in recognition of his or her outstanding contributions to research improving the care of women with gynecologic cancer. The awardees will have made important contributions  that improve gynecologic cancer patient care,  including early detection. The award will be made to the  individual rather than his/her institution. The prize is funded by the Claudia Cohen Research Foundation (CCRF) in honor of Claudia Cohen who lost her battle with uterine leiomyosarcoma in 2007. Ms. Cohen was a highly respected journalist and philanthropist. The Claudia Cohen Research Foundation was founded by Ms. Cohen’s daughter Samantha, and her sisters Caleigh and Debra Perelman to foster research aimed at reducing the burden of gy...
Interleukin-11 in Endometrial Adenocarcinoma Is Regulated by Prostaglandin F2{alpha}-F-Prostanoid Receptor Interaction via the Calcium-Calcineurin-Nuclear Factor of Activated T Cells Pathway and Negatively Regulated by the Regulator of Calcineurin-1.
This study investigated the expression of IL-11 and role of prostaglandin F2alpha-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells. Localization of IL-11, IL-11Ralpha, and GP130 expression was performed by immunohistochemistry. IL-11 and regulator of calcineurin 1 isoform 4 (RCAN1-4) mRNA and protein expression were determined by real-time RT-PCR and/or enzyme-linked immunosorbent assay/Western blot analysis using Ishikawa endometrial adenocarcinoma cells stably expressing the FP receptor (FPS cells) and endometrial adenocarcinoma explants. IL-11 mRNA expression was significantly elevated in endometrial adenocarcinoma samples compared with normal endometrium and increased with tumor grade. IL-11 protein expression local...
Endometrial Cancer Side-Population Cells Show Prominent Migration and Have a Potential to Differentiate into the Mesenchymal Cell Lineage.
In this study, we isolated and characterized the SP cells in human endometrial cancer cells and in rat endometrial cells expressing oncogenic human K-Ras protein. These SP cells showed i) reduction in the expression levels of differentiation markers; ii) long-term proliferative capacity of the cell cultures; iii) self-renewal capacity in vitro; iv) enhancement of migration, lamellipodia, and uropodia formation; and v) enhanced tumorigenicity. In nude mice, SP cells formed large, invasive tumors, which were composed of both tumor cells and stromal-like cells with enriched extracellular matrix. The expression levels of vimentin, alpha-smooth muscle actin, and collagen III were enhanced in SP tumors compared with the levels in non-SP tumors. In addition, analysis of microdissected samples and...
Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line
Discussion  Here, we show for the first time that the novel inhibin/activin-betaC and -betaE subunits are expressed in normal human endometrium and the estrogen receptor positive human endometrial carcinoma cell line Ishikawa using RT-PCR and immunohistochemical detection methods. Interestingly, the Ishikawa minus cell line (lacking estrogen receptor expression) demonstrated no to minimal expression of the betaC subunit as observed with immunofluorescence and RT-PCR, suggesting a possible hormone- dependency of this subunit in human endometrial cancer cells. Moreover, because the Ishikawa cell line minus is thought to be a more malignant endometrial cell line than its estrogen receptor positive counterpart, inhibin-betaC subunit might be substantially involved in the pathoge...
Hormone replacement after gynaecological cancer
Abstract: Treatment of gynaecological cancer frequently results in the loss of ovarian function and menopausal symptoms. Symptoms of iatrogenic menopause are usually significantly more intense than those of natural menopause due to sudden onset of symptoms, younger age and its effects on common physical and psychological problems of cancer therapy like body image concerns and sexual dysfunction. The most effective treatment for menopausal symptoms is hormone replacement therapy (HRT). However, it is very controversial if HRT is safe in patients after a gynaecological malignancy. The main concerns are the potential stimulation of residual cancer and the induction of new hormone-dependent disease. However, the majority of the most common gynaecological malignancies like squamous cell carcino...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
An Exploration of Shared Genetic Risk Factors Between Periodontal Disease and Cancers: A Prospective Co-Twin Study.
Authors: Arora M, Weuve J, Fall K, Pedersen NL, Mucci LA Biologic mechanisms underlying associations of periodontal disease with cancers remain unknown. The authors propose that both conditions share common genetic risk factors. They analyzed associations between baseline periodontal disease, measured by questionnaire-recorded tooth mobility, and incident cancers, identified by linkage with national registries, between 1963 and 2004 in 15,333 Swedish twins. The authors used co-twin analyses to control for familial factors and undertook analyses restricted to monozygotic twins to further control for confounding by genetic factors. They observed 4,361 cancer cases over 548,913 person-years. After adjustment for covariates, baseline periodontal disease was associated with increased risk o...
Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient
This report serves to emphasize the need to improve guidelines for screening of at risk individuals, including the necessity for predictive genetic testing and early institution of tumour surveillance in childhood. Content Type Journal ArticleDOI 10.1007/s10689-009-9306-0Authors Ismail Alrashdi, St George?s Hospital Medical School Department of Medical Genetics Cranmer Terrace SW17 0RE London UKSamantha Levine, St George?s Healthcare Trust Department of Cellular Pathology London UKJoan Paterson, Addenbrooke?s Hospital Medical Genetics, Addenbrooke?s Treatment Centre Cambridge UKRohit Saxena, Mayday University Hospital Department of Paediatrics Croydon UKSoonie R. Patel, Mayday University Hospital Department of Paediatrics Croydon UKSarita Depani, Royal Marsden Hospital Paedi...
Ovarian Cancer Op Doesn't Have To End Fertility
Most women diagnosed with ovarian cancer undergo a hysterectomy, with removal of the uterus and both ovaries. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)
Soy may lessen risk of endometrial, ovarian cancers
NEW YORK (Reuters Health) - Women who eat more soy-based foods than average may have less risk for certain cancers in the ovaries and the lining of the uterus, according to the combined findings of a few studies. (Source: Reuters: Health)
Soy May Lessen Risk of Endometrial, Ovarian Cancers
Women who eat more soy-based foods than average may have less risk for certain cancers in the ovaries and the lining of the uterus, according to the combined findings of a few studies. Source: Reuters Health Related MedlinePlus Topics: Nutrition, Ovarian Cancer, Uterine Cancer (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
What Is Vaginal Cancer? What Causes Vaginal Cancer?
Vaginal cancer is a rare type of cancer. It occurs in the vagina which is the muscular tube that connects the uterus with the outer genitals. Vaginal cancer most commonly occurs in the cells that line the surface of the vagina, which is sometimes called the birth canal... (Source: Cancer / Oncology News From Medical News Today)
What Is Vaginal Cancer? What Causes Vaginal Cancer?
Vaginal cancer is a rare type of cancer. It occurs in the vagina which is the muscular tube that connects the uterus with the outer genitals. Vaginal cancer most commonly occurs in the cells that line the surface of the vagina, which is sometimes called the birth canal. While several cancers can spread to the vagina from other places in the body, cancer that begins in the vagina (primary vaginal cancer) is rare. Vaginal cancer comprises only 2 to 3 percent of gynecologic cancers. Women with early-stage vaginal cancer have the best chance for a cure... (Source: Health News from Medical News Today)
In response to "Comparison of surgery or radiotherapy on complications and quality of life in patients with the stage IB and IIA uterine cervical cancer"
Authors: Hsu WC, Chung NN, Chen YC PMID: 19962741 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Abstract IA-6: Single nucleotide polymorphisms in the p53 pathway
The p53 protein and the signal transduction pathway controlled by that protein responds to a wide variety of stress signals which can disrupt the fidelity of DNA replication and cell division. To prevent these errors or mutations the p53 pathway responds by initiating a process of cell cycle arrest, senescence or apoptosis which either permits repair of these errors or kills the clone of cells that contain these mutations. Central to this pathway are a series of proteins that respond to the stress signals and regulate the levels and activity of the p53 pathway. We have identified a number of single nucleotide polymorphisms (SNP) in those genes that regulate p53 activity and functions and these SNPs can play a role in the incidence of cancers in a population, the age of onset of cancers and...
Abstract C67: Hypoxia-inducible factor-2{alpha} regulates macrophage functions in both acute and tumor inflammation
Hypoxia and inflammation in the tumor microenvironment profoundly influence carcinogenesis and tumor progression. In order to connect hypoxic signaling to inflammatory responses and their roles in oncogenesis, we investigated how one of the master regulators of hypoxic hypoxia-inducible factor (HIF)-2, adaptations, regulates macrophage functions in both acute inflammatory diseases and cancer (a disease involving various inflammatory components). Myeloid-specific deletion of HIF-2 results in defective expression of a panel of proinflammatory cytokines in macrophages responding to innate stimuli. Also, mice lacking myeloid HIF-2 are resistant to lipopolysaccharide-induced endotoxemia and display a marked inability to mount inflammation in response to several other acute irritants, revealing ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Femur metastasis in carcinoma of the uterine cervix: a rare entity
Conclusion  Bone metastasis is not so infrequent in patients with LACC. Because the prognosis of these patients is poor and most of them die within 1 year after the diagnosis of metastatic disease, the policy of treatment should be directed to maintain their quality of life. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1307-6Authors Giacomo Corrado, Catholic University of the Sacred Heart Gynecologic Oncology Unit, Department of Oncology L.go A. Gemelli, 1 86100 Campobasso ItalySalvatore Santaguida, Catholic University of the Sacred Heart Gynecologic Oncology Unit, Department of Oncology L.go A. Gemelli, 1 86100 Campobasso ItalyGianfranco Zannoni, Catholic University of the Sacred Heart Institute of Human Pathology Rome ItalyGiov...
The effect of cyclooxygenase-2 expression on tumor volume response in patients treated with radiotherapy for uterine cervical cancer.
In conclusion, the COX-2 expression status has no significant correlation with the tumor response. Further studies on the changes in COX-2 expression levels during RT may be helpful for determination of its role in the tumor response to treatment and patient prognosis. PMID: 19949677 [PubMed - in process] (Source: J Korean Med Sci)
Chemosensitivity of uterine cervical cancer demonstrated by the histoculture drug response assay.
Authors: Lee SW, Kim YM, Kim MB, Kim DY, Kim JH, Nam JH, Kim YT Uterine cervical cancer is a leading cause of cancer-related death in the female population worldwide. In vitro chemosensitivity test is important to find effective drugs in uterine cervical cancer that requires the established chemotherapeutic strategies. The purpose of this study is to investigate the chemosensitivity of uterine cervical cancer using the histoculture drug response assay (HDRA). Sixty-five fresh tumor tissues were obtained from patients with cervical cancer: 47 squamous cell carcinomas, 11 adenocarcinomas, and 7 adenosquamous cell carcinomas. The median age was 44 years (range, 25-74 years), and the median follow-up duration was 26.3 months (range, 1.6-52.7 months). The clinical stage by the International...
Robotic Assisted Rectal Cancer Surgery
The intended application of robotics in surgery was in the field of cardiac surgery. The addition of robot was thought to improve surgeon dexterity in a small field with the added advantage of a minimal invasive approach. Shortly thereafter, urologists recognized that this modality could be used in the deep pelvis and brought the robot to its current most widely used application, the robotic prostatectomy. In the subsequent years, the use of this technology for other ?pelvic organs? such as the uterus, rectum, and bladder evolved. Similarly, during this time period, minimally invasive surgical techniques were being studied in colorectal surgery. The results of the Clinical Outcomes of Surgical Therapy trial in 2004 concluded that laparoscopic approaches to colon cancer could be perform...
Diagnostic approach for precancerous and early invasive cancerous lesions of the uterine cervix.
Authors: Grubisić G, Klarić P, Jokanović L, Soljacić Vranes H, Grbavac I, Bolanca I Invasive cervical cancer is second most common female cancer worldwide with about 493,000 new cases per year. About 273,000 women die from cervical cancer each year, 85% of which take place in developing countries. Cervical cancer has a slow progress, from pre-invasive cervical intraepithelial neoplasia (CIN) to invasive phases, meaning that the disease can be diagnosed while in the phase of pre-invasive lesion, and treated successfully thanks to the regular screening of asymptomatic women (the Pap smear). The authors review new possibilities of early detection of cervical cancer with emphasis on colposcopy. The role of colposcopy is discussed among possibilities of early diagnos...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Regional Differences in Prevalence of Anemia Found by Periodic Health Checkups at Workplaces.
Authors: Shimomura T, Wakabayashi I Anemia-related blood examinations are included in examinations for periodic health checkups at workplaces designated by the Industrial Safety and Health Law in Japan. The aim of this study was to determine whether there were regional differences in the prevalence of anemia in workers and, if so, to investigate possible reasons for the differences. Relationships between prevalence of anemia found by periodic health checkups and some common factors related to anemia in each prefecture of Japan were investigated by ecological regression analysis using Spearman's rank correlation coefficient. There were regional differences in the prevalence of anemia in the prefectures of Japan (5.1-11.7%), and high prevalence was observed in prefectures in the northeas...
Cigarettes Damage More Than Lungs
Most everyone understands that smoking cigarettes greatly increases the risk of lung cancer. Unfortunately, not nearly as many people understand the connection between smoking and risk of other cancers. Now we can definitively add colon and rectum (colorectal) cancers to the list of diseases caused by smoking. In one of the most comprehensive studies on this topic to date, researchers discovered that a long-term history of smoking increases risk of colorectal cancer by 30-50%. In particular, colorectal cancer risk was highest in those who did not quit smoking before age 40 or who smoked cigarettes for 40 or more years. If you smoke, quitting smoking is the single best thing you can do to improve your health and reduce your risk of cancer. Along with the new study showing that smoking signi...
Quality Assurance in the Prospective Multi-institutional Trial on Definitive Radiotherapy Using High-dose-rate Intracavitary Brachytherapy for Uterine Cervical Cancer: The Individual Case Review
Conclusions The present ICR demonstrated the favorable radiotherapy compliance with the JAROG0401/JROSG04-2 protocol. The QA process using ICRs can potentially be used to improve the quality of radiotherapy, including HDR-ICBT in the multi-institutional prospective studies for cervical cancer. (Source: Japanese Journal of Clinical Oncology)
Basal cell carcinoma arising on a chronic lymphedematous leg
We describe a case of an 82-year-old Japanese woman with basal cell carcinoma (BCC) on the leg with secondary chronic lymphedema due to treatment for uterine cancer. Sparse tumor nests with remarkable edema of the dermis in the nodule appeared to be influenced by the chronic lymphedema. However, it remains inconclusive whether or not the tumorigenesis of the BCC was associated with chronic lymphedema in this case. (Source: The Journal of Dermatology)
Use of fertility drugs and risk of uterine cancer
Source: Am J Epidemiol Area: News In contrast to the fairly large number of studies that have investigated the association between fertility drugs and ovarian cancer and breast cancer, only a few epidemiological studies have assessed the link with uterine cancer and findings from these studies have been conflicting. Therefore researchers established a cohort of 54,362 Danish women who attended infertility clinics during the period 1965-1998 to further assess the association between fertility drugs and risk of uterine cancer. A case-cohort study evaluated the effects of different types of fertility drugs on uterine cancer risk.   The following findings were reported:   . Through mid-2006, 83 uterine cancers were identified.   . Ever use of any fertility...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Epithelial maturation and molecular biology of oral HPV
Human papillomavirus (HPV) is widespread and can cause latent infection in basal cells, with low HPV DNA copy-number insufficient for transmission of infection; can cause subclinical infection that is active but without clinical signs; or can cause clinical infection leading to benign, potentially malignant or malignant lesions. The HPV cycle is influenced by the stage of maturation of the infected keratinocytes, and the production of virions is restricted to the post-mitotic suprabasal epithelial cells where all the virus genes are expressed.Low-risk HPV genotypes are associated with the development of benign oral lesions, whereas high-risk HPV genotypes are implicated in the development of malignant epithelial neoplasms. The role of high-risk HPV as a causative agent in epithelial malign...
Fertility drugs may pose some uterine cancer risk
NEW YORK (Reuters Health) - Though the use of fertility drugs does not seem to generally increase uterine cancer risk, a Danish study identified small increases in risk from certain fertility drugs used for longer duration. (Source: Reuters: Health)
Fertility Drugs May Pose Some Uterine Cancer Risk
Though the use of fertility drugs does not seem to generally increase uterine cancer risk, a Danish study identified small increases in risk from certain fertility drugs used for longer duration. Source: Reuters Health Related MedlinePlus Topics: Hormones, Infertility, Uterine Cancer (Source: MedlinePlus Health News)
Prognostic nomogram for overall survival in stage IIB-IVA cervical cancer patients treated with concurrent chemoradiotherapy
Conclusion: This nomogram is a predictive tool, upon external validation, that can be used to counsel patients in predicting outcomes. The discriminatory ability of the nomogram indicates that this population should not be considered homogeneous with respect to risk of death. (Source: American Journal of Obstetrics and Gynecology)
Postmenopausal bleeding
(PMB) is a symptom of possible gynaecological malignancy. According to present guidelines, women presenting with this symptom should be referred urgently to a team specializing in the management of gynaecological cancer, and be seen within two weeks of referral. Examination and investigation of these women should be able to exclude malignancy, while being acceptable to the patient and cost-effective. The gold standard modality of investigation to visualize the uterine cavity is hysteroscopy, but transvaginal scanning is recommended as the first-line investigation to select those who need further diagnostic evaluation. Hysteroscopy should be performed in women with a thickened endometrium on scan and women with recurrent episodes of bleeding despite negative scan findings. There have been ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Obesity and Cancer
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precursor” condition such as gallstones. The increased cancer risk in patients with obesity is a neglected topic which deserves more scientific attention. Because of its...
Peutz-Jeghers syndrome: diagnostic and therapeutic approach.
Authors: Kopacova M, Tacheci I, Rejchrt S, Bures J Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280,000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome. Prophylaxis and polypectomy of the entire sm...
Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study
Some epidemiologic studies have indicated that uterine cancer risk may be increased after use of fertility drugs. To further assess this association, the authors used data from a large cohort of 54,362 women diagnosed with infertility who were referred to Danish fertility clinics between 1965 and 1998. In a case-cohort study, rate ratios and 95% confidence intervals were used to assess the effects of 4 groups of fertility drugs on overall risk of uterine cancer after adjustment for potentially confounding factors. Through mid-2006, 83 uterine cancers were identified. Ever use of any fertility drug was not associated with uterine cancer risk (rate ratio (RR) = 1.10, 95% confidence interval (CI): 0.69, 1.76). However, ever use of gonadotropins (follicle-stimulating hormone and human menopaus...
Anesthetic management of a patient with hyperthyroidism due to hydatidiform mole
We report here the perioperative management of hyperthyroidism due to hydatidiform mole. A 53-year-old woman underwent emergency surgery due to suspicion of hydatidiform mole. Tachycardiac atrial fibrillation was detected by electrocardiography at the preoperative examination. No abnormalities were found in blood count, coagulation, biochemical tests, chest radiographs, or respiratory function. General anesthesia with nitrous oxide, oxygen, and sevoflurane, combined with fentanyl and 1% mepivacaine, was administered intermittently from an epidural catheter. Intraoperative events included hypotension and tachycardia, although in general, tachycardia was prevented with antiarrhythmic agents and transfusion with a plasma expander and crystalloid fluid. Hyperthyroidism was highly suspec...
The endometrium--from estrogens alone to TSECs.
This article reviews publications dating back more than a century describing investigations of the endometrium, including those examining the relationship between endometrial hyperplasia and carcinoma, the influence of estrogens on the endometrium, and strategies for protecting the endometrium from unopposed estrogen stimulation. Endometrial hyperplasia and carcinoma studies date from before 1900. The influence of endogenous estrogens on the endometrium became evident with observations of endometrial hyperplasia and/or carcinoma in women with estrogen-secreting tumors or polycystic ovarian disease. Later, observational studies and randomized, controlled trials suggested a relationship between unopposed estrogens and endometrial cancer and hyperplasia. The first, and to date only, effective...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations.
CONCLUSION: This study provides evidence that the risk of developing gynecological cancers with E/D use of several months to a few years is similar to the risks of developing gynecological cancer without HRT or use of other HRT. PMID: 19905903 [PubMed - in process] (Source: Climacteric)
Endometrial cancer.
Authors: Buchanan EM, Weinstein LC, Hillson C Endometrial cancer is the leading cause of gynecologic cancer in the United States. Etiologically, endometrial carcinoma usually results from unopposed estrogen stimulation of the endometrium, although non-estrogen-related forms occur as well. The most common presentation of endometrial cancer is postmenopausal bleeding. A variety of diagnostic modalities are available to aid in the detection of the disease, each with its own strengths and limitations. These modalities include endometrial biopsy, ultrasonography, saline infusion sonography, and hysteroscopy. A definitive diagnosis requires pathologic confirmation via endometrial biopsy or dilatation and curettage. Surgical staging of endometrial cancer will dictate how physicians manage the...
Macrophage migration inhibitory factor expression in cervical cancer
Conclusions  MIF has been shown to promote tumor immune escape mechanisms in other cancer entities, which makes it an interesting target for cancer therapy, given the known significance of immune mechanisms for uterine cervical cancer. The overexpression of MIF on the protein and mRNA level, as well as its secretion by cervical cancer cells points to a critical role of the protein for the pathogenesis of uterine cervical cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0702-5Authors Mathias Krockenberger, University of Wuerzburg Department of Obstetrics and Gynecology Josef-Schneider-Str. 4 97080 Würzburg GermanyJörg B. Engel, University of Wuerzburg Department of Obstetrics and Gynecology Josef-Schneider-Str. 4 97080 Würzburg Germa...
p53 regulates LIF expression in human medulloblastoma cells
Abstract  Medulloblastomas are highly malignant, poorly differentiated childhood tumours arising in the cerebellum. These tumors rarely lose TP53, which is the most commonly mutated gene in cancer. Recent work has shown that the basal level of p53 plays an important role in maternal reproduction by maintaining the expression of LIF in the uterus. Since LIF can maintain the undifferentiated state of stem cells we set out to ask if p53 regulates LIF in the human medulloblastoma cell lines DAOY and D283MED. We also used p53?/? and p53+/+ isogenic HCT116 colorectal carcinoma cell lines, already reported to exhibit p53-dependent expression of the LIF D transcript, to establish the extent of p53-dependency for LIF M and T alternative transcripts. Whilst all three known, ...
Estrogens, MSI and Lynch syndrome-associated tumors.
Authors: Ferreira AM, Westers H, Albergaria A, Seruca R, Hofstra RM Estrogens play a major role in the biology of hormone-responsive tissues but also in the normal physiology of various non-typical hormone-responsive tissues. In disease, estrogens have been associated with tumor development, in particular with tumors such as breast, endometrium, ovary and prostate. In this paper we will review the molecular mechanisms by which estrogens are involved in cancer development, with a special focus in Lynch syndrome related neoplasia. Further, we discuss the role estrogens might have on cell proliferation and apoptosis, how estrogens metabolites can induce DNA damage and we discuss a possible connection between estrogens and changes in DNA (hypo- and hyper) methylation. In this review we wil...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2 [Gynecologic Cancer]
Conclusion Laparoscopic surgical staging for uterine cancer is feasible and safe in terms of short-term outcomes and results in fewer complications and shorter hospital stay. Follow-up of these patients will determine whether surgical technique impacts pattern of recurrence or disease-free survival. (Source: Journal of Clinical Oncology)
Research Conducted At Johns Hopkins University Has Updated Our Knowledge About Endometrial Cancer
Uterine serous carcinomas typically have a characteristic morphology (papillary architecture, high-grade nuclei) and immunoprofile (diffuse/strong p53 expression, loss of hormone receptor expression) that distinguish them from most endometrial endometrioid carcinomas. (Source: Cancercompass News: Other Cancer)
Predictive Value of FIGO and AJCC Staging Systems in Patients With Uterine Leiomyosarcoma
Neither the FIGO nor the AJCC system adequately classifies ULMS patients into clinically meaningful prognostic groups. Background: Cancer staging systems aim to identify patient cohorts with different... (Source: OncologySTAT Journal Scans)
A. Eugene Washington appointed as dean of the David Geffen School of Medicine and Vice Chancellor of Health Sciences at UCLA
Message to UCLA administrative officers, deans, department chairs, directors, vice chancellors and faculty of the medical echool and medical sciences from Scott Waugh, executive vice chancellor and provost:   Dear Colleagues:   I am very pleased to inform you that Chancellor Block and I have proposed for UC Regents’ approval the appointment of A. Eugene Washington as dean of the David Geffen School of Medicine and vice chancellor of health sciences at UCLA, effective February 1, 2010.   Dr. Washington currently serves as executive vice chancellor & provost and professor of gynecology, epidemiology, and health policy at the University of California, San Francisco (UCSF).  A member of the UCSF faculty since 1983, Dr. Washington served as chair of...
Inducible heat shock protein 70 enhances HPV31 viral genome replication and virion production during the differentiation-dependent life cycle in human keratinocytes.
In this study we carry out analyses in the natural host epithelial tissues to assess the role of inducible HSP70 (HSP70i) in the HPV infectious life cycle. For these studies we used the organotypic (raft) culture system to recapitulate the full viral life cycle of the high-risk HPV31. Upon heat shock of HPV31 infected organotypic tissues, we find high and sustained expression of HSP70i coincident with enhanced HPV genome replication and virion production. Whereas there is no clear effect on L1 expression levels, we find HSP70i and L1 interact and HSP70i colocalizes with and enhances the nuclear localization of L1 in differentiated cells. Ad-mediated gene transfer was used to study the effects of HSP70i in naturally HPV-infected differentiating tissues and showed results similar to those in...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
RBSP3 is frequently altered in premalignant cervical lesions: Clinical and prognostic significance
To understand the importance of frequent deletion of 3p22.3 in cervical carcinogenesis, alterations (deletion/methylation/expression) of the candidate genes STAC, MLH1, ITGA9, and RBSP3, located in the region, were analyzed in 24 cervical intraepithelial neoplasia (CIN) and 137 uterine cervical carcinoma (CACX) samples. In CIN, RBSP3 deletion (48%) and methylation (26%) were high compared with the other genes (4-9%). In CACX, alterations of these genes were as follows: deletion: STAC (54%) > MLH1 (46%) > RBSP3 (45%) > ITGA9 (41%), methylation: RBSP3 (25%) > ITGA9 (24%) > STAC (19%) > MLH1 (13%). Overall, alterations of RBSP3 showed association with CIN, whereas for STAC and MLH1, this frequency increased significantly from CIN [rarr] Stage I/II and for ITGA9 from CIN [rarr] Stage I/II and ...
A case with spontaneous bladder rupture mimicking acute kidney injury.
We report a case with spontaneous bladder rupture mimicking acute kidney injury forty years after postoperative pelvic irradiation for uterine cancer. PMID: 19863882 [PubMed - in process] (Source: Clinical Nephrology)
Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study.
Authors: Jensen A, Sharif H, Kjaer SK Some epidemiologic studies have indicated that uterine cancer risk may be increased after use of fertility drugs. To further assess this association, the authors used data from a large cohort of 54,362 women diagnosed with infertility who were referred to Danish fertility clinics between 1965 and 1998. In a case-cohort study, rate ratios and 95% confidence intervals were used to assess the effects of 4 groups of fertility drugs on overall risk of uterine cancer after adjustment for potentially confounding factors. Through mid-2006, 83 uterine cancers were identified. Ever use of any fertility drug was not associated with uterine cancer risk (rate ratio (RR) = 1.10, 95% confidence interval (CI): 0.69, 1.76). However, ever use of gonadotropins (folli...
Coffee may lower endometrial cancer risk
NEW YORK (Reuters Health) - Women dread a diagnosis of endometrial cancer, but those who drink at least two cups of caffeinated coffee a day may have a lower risk for this cancer of cells lining the uterus. (Source: Reuters: Health)

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cancer of the salivary gland

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cancer of the salivary gland
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