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Current Status of Chromoendoscopy and Narrow Band Imaging in Colonoscopy Clinics in Colon and Rectal Surgery 2010; 23: 021-030DOI: 10.1055/s-0030-1247853ABSTRACTColonoscopy, the preferred procedure for colon cancer screening, has well-documented limitations. To improve colonoscopy's effectiveness, augmented endoscopy techniques, such as chromoendoscopy and narrow band imaging (NBI) have been evaluated. Both techniques are inexpensive, safe, and relatively easy to perform. Chromoendoscopy has an increasingly important role in surveillance of IBD, but significant work is needed to determine the optimal staining techniques and mucosal surface pattern analysis before this technique can be incorporated into routine clinical practice. NBI is a much newer technology with far less data. Well-designed prospective randomized controlled trials have failed to identify a be...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Laparoscopy for Colon and Rectal Cancer Clinics in Colon and Rectal Surgery 2010; 23: 051-058DOI: 10.1055/s-0030-1247856ABSTRACTLaparoscopy has emerged as a useful tool in the surgical treatment of diseases of the colon and rectum. Specifically, in the application of colon cancer, a laparoscopic-assisted approach offers short-term benefits to patients while maintaining a long-term oncologic outcome. Hand-assisted laparoscopic surgery may help decrease operative times while preserving the benefits of laparoscopy. The literature on the use of laparoscopy for rectal cancer is still in its early stages. Limited data suggest short-term benefits without compromising oncologic outcome; however, data from large multicenter trials will clarify the role of laparoscopy in the treatment of rectal cancer. Robotic proctectomy is a novel techn... Video: First Ever Live TV Anchor Colonoscopy In Full: CBS Evening News anchor Katie Couric guided The Early Show anchor Harry Smith through a colonoscopy on live TV. Couric is an advocate of colorectal cancer prevention. (Source: Health News: CBSNews.com) March is National Colorectal Cancer Awareness Month March 9, 2010 - Events are taking place all around the country during March to raise awareness of colorectal cancer, which is the third most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the U.S. The American Cancer Society estimates that about 146,970 new cases and 49,920 deaths expected in 2009. (Source: NurseZone.com Nursing News) Video: First Ever Live TV Colonoscopy In Full: CBS Evening News anchor Katie Couric guided The Early Show anchor Harry Smith through a colonoscopy on live TV. Couric is an advocate of colorectal cancer prevention. (Source: Health News: CBSNews.com) Obesity and Colon Cancer Source: HealthDay -
Related MedlinePlus Pages: Colorectal Cancer, Obesity (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Inside Colonoscopy Screenings Dr. Mark Pochapin Explains How Doctors Perform This Important Test for Colon Cancer (Source: Health News: CBSNews.com) Link Between Obesity And Poor Colon Cancer Prognosis Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Obesity has long been established as a risk factor for cancer, but our study in colon cancer patients shows that obesity predicts a poorer prognosis after the cancer is surgically removed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic in Rochester... (Source: Health News from Medical News Today) Link Between Obesity And Poor Colon Cancer Prognosis Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research... (Source: Obesity / Weight Loss / Fitness News From Medical News Today) Irritable Bowel Syndrome Patients Not More Likely To Get Colon Cancer Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology. "Patients and doctors get nervous about the symptoms of irritable bowel syndrome (IBS)," says William D. Chey, M.D., professor of Internal Medicine at the University of Michigan Medical School. "They think the symptoms represent something more sinister... (Source: Health News from Medical News Today) Irritable Bowel Syndrome Patients Not More Likely To Get Colon Cancer Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology. "Patients and doctors get nervous about the symptoms of irritable bowel syndrome (IBS)," says William D. Chey, M.D... (Source: GastroIntestinal News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Recentin Did Not Meet Primary Endpoint In Horizon III Study in mCRC Anglo-Swedish pharmaceutical company AstraZeneca plc reported on Monday that Recentin (cediranib) did not meet the primary endpoint in the Horizon III study in metastatic colorectal cancer. (Source: Cancercompass News: Colorectal Cancer) Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer Researchers say that obesity leads to more aggressive colon
cancer and that the risk differs between men and women
ROCHESTER, Minn.--(BUSINESS WIRE)--Mar 9, 2010 - It's long been
known that obesity is linked to increased risk of developing... (Source: Drugs.com - Clinical Trials) Obese Colon Cancer Survivors Face Poorer Prognosis Study found chances of recurrence, death higher than among normal-weight patients
Source: HealthDay
Related MedlinePlus Pages: Colorectal Cancer, Obesity (Source: MedlinePlus Health News) Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: News from Mayo Clinic) Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: Mayo Clinic Research News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: Mayo Clinic Rochester News) The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects. (Source: Journal of Biomedicine and Biotechnology) Video: Peter Yarrow on Colon Health Singer Peter Yarrow spoke with Harry Smith about the death of Mary Travers and his campaign for colon cancer prevention. (Source: Health News: CBSNews.com) 'Giant colon' promotes colorectal cancer screening The Colorectal Cancer Association of Canada, in conjunction with government partners, has been taking a "giant colon" on the road to cities across Ontario to educate people about the disease and to promote the need for screening. (Source: CTV Health) Menopausal Hormone Therapy Use and Risk of Invasive Colon Cancer Does hormone replacement therapy in menopausal women decrease the risk of invasive colon cancer? American Journal of Epidemiology (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Like Little Golden Assassins, 'Smart' Nanoparticles Identify, Target And Kill Cancer Cells Another weapon in the arsenal against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone. Led by Carl Batt, the Liberty Hyde Bailey Professor of Food Science, the researchers synthesized nanoparticles shaped something like a dumbbell made of gold sandwiched between two pieces of iron oxide. They then attached antibodies, which target a molecule found only in colorectal cancer cells, to the particles. Once bound, the nanoparticles are engulfed by the cancer cells... (Source: Health News from Medical News Today) High weight associated with risk of colorectal tumors without microsatellite instability The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability, a common condition in most colorectal cancers, according to a new study. (Source: ScienceDaily Headlines) Obesity linked to poor colon cancer prognosis (American Association for Cancer Research) Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Social and Behavioral Science) Patients with Irritable Bowel Syndrome not more likely to develop polyps, colon cancer (University of Michigan Health System) Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies. (Source: EurekAlert! - Medicine and Health) Metastasis of colon cancer to the thyroid gland: A case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach Fine-needle aspiration (FNA) with cytological evaluation reliably diagnoses primary and secondary thyroid neoplasms. However, identifying the primary origin of a metastatic process involving the thyroid gland is challenging. In particular, metastasis of colon cancer to the thyroid gland is very rare. In this case report, a right lobe solid thyroid nodule in a 66-year-old male was aspirated. FNA cytology showed necrosis and atypical tall columnar cells; since, the patient at age 60 had undergone surgery for a sigmoid-rectal cancer metastasizing to the liver and subsequently to the lung, a suspicion of metastasis from colon cancer was raised. This was corroborated by cell-block immunocytochemistry showing a cytokeratin (CK) 7 negative/CK20-positive staining pattern; thyreoglobulin and TTF-1 ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Colorectal cancer screening using the faecal occult blood test (FOBt): A survey of GP attitudes and practices in the UK Conclusions:
The success of population-based screening for CRC will largely be determined by GP attitudes and support, particularly with regard to FOBt. Previous research has implied that South Asian GPs are more likely to have negative attitudes towards FOBt screening, however, our research suggests that this is not a group requiring targeted interventions to increase their support for the NHSBCSP. Of the available CRC screening tests, GPs perceived FOBt to be the most appropriate for population-based screening. (Source: BMC Family Practice) Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis Authors: R Zarate, J Rodríguez, E Bandres, A Patiño-Garcia, M Ponz-Sarvise, A Viudez, N Ramirez, N Bitarte, A Chopitea
& J Gacía-Foncillas (Source: British Journal of Cancer AOP) Obesity Linked to Higher Mortality Rate in Colon Cancer In patients with colon cancer, obesity was associated with higher rates of cancer recurrence and
mortality, according to research published online March 9 in Clinical Cancer Research. (Source: Modern Medicine) Skin Toxicity Evaluation Protocol With Panitumumab (STEPP), a Phase II, Open-Label, Randomized Trial Evaluating the Impact of a Pre-Emptive Skin Treatment Regimen on Skin Toxicities and Quality of Life in Patients With Metastatic Colorectal Cancer [Gastrointestinal Cancer] Conclusion
The pre-emptive skin treatment regimen was well tolerated. The incidence of specific ≥ grade 2 skin toxicities during the 6-week skin treatment period was reduced by more than 50% in the pre-emptive group compared with the reactive group. Patients in the pre-emptive group reported less QOL impairment than patients in the reactive group. (Source: Journal of Clinical Oncology) Facilitating Informed Decisions Regarding Microsatellite Instability Testing Among High-Risk Individuals Diagnosed With Colorectal Cancer [Gastrointestinal Cancer] Conclusion
Incorporation of new media education strategies for individuals at risk for LS may be a valuable component of the informed consent process. As clinical criteria for MSI and IHC testing continue to expand, the need for alternative educational approaches to meet this increased demand could be met by the self-administered computer-based strategy that we described. (Source: Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Optimized St. John's Wort (Hypericum perforatum L.) Germplasm Lines Exert Cytotoxicity in HT-29 Colon Cancer Cells via Downregulation of NF-?B Extracts of two germplasm lines of St. John's wort (SJW; Hypericum perforatum L.) selected for enhanced hypericin and hyperforin content were evaluated for potential activity against colon cancer. Bioactivity was assessed in signaling pathways of tumor necrosis factor-a (TNF-?) and nuclear transcription factor-?B (NF-?B) in HT-29 colon cancer cells. Both extracts and the hypericin standard significantly inhibited growth of HT-29 cells. Levels of active NF-?B were reduced in cells treated with either of the plant extracts or hypericin, but the purified hyperforin standard was comparatively ineffective. The combination of TNF-? and SJW treatments had significantly higher cytotoxic effects, and reduced the expression of NF-?B, inhibitor of NF-?Bs (I?Ba), I?B kinase b (IKKb), and TNF ... Rapid Expansion of Intravitreal Drug Injection Procedures, 2000 to 2008: A Population-Based Analysis [Socioeconomics and Health Services] Conclusions The development of vascular endothelial growth factor inhibitors has revolutionized the treatment of age-related macular degeneration. To our knowledge, this study is the first to quantify the dramatic uptake of these treatments at a population level. Our findings also suggest that off-label injection of bevacizumab was highly prevalent in Ontario. Serial intravitreal injections requiring direct physician administration and the concentration of injection procedures in the hands of a small number of ophthalmologists have the potential to affect services for other vision-threatening conditions. (Source: Archives of Opthalmology) New Insights Into Susceptibility to Glioma [Neurological Review] The study of inherited susceptibility to cancer has been one of the most informative areas of research in the past decade. Most of the cancer genetics studies have been focused on the common tumors such as breast and colorectal cancers. As the allelic architecture of these tumors is unraveled, research attention is turning to other rare cancers such as glioma, which are also likely to have a major genetic component as the basis of their development. In this brief review we discuss emerging data on glioma whole genome–association searches to identify risk loci. Two glioma genome-wide association studies have so far been reported. Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872).... Positron Emission Tomography-Computed Tomography in Paraneoplastic Neurologic Disorders: Systematic Analysis and Review [Original Contribution] Conclusion In a paraneoplastic neurologic context, PET-CT improves the detection of cancers when other screening test results are negative, particularly in the setting of seropositivity for a neuronal nuclear or cytoplasmic autoantibody marker of cancer.
Published online January 11, 2010 (doi:10.1001/archneurol.2009.336). (Source: Archives of Neurology) Chemotherapy-Associated Peripheral Sensory Neuropathy Assessed Using In Vivo Corneal Confocal Microscopy [Images in Neurology] (Source: Archives of Neurology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> 5. A novel biomarker of axonal dysfunction in oxaliplatin-induced neurotoxicity Introduction: Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of colorectal cancer, produces prominent dose-limiting neurotoxicity. Acute neurotoxicity develops immediately following infusion and resolves within days, while chronic neuropathy develops with higher cumulative doses. (Source: Clinical Neurophysiology) Screening and Identification of Recombinant Anti-Idiotype Antibodies against Gastric Cancer and Colon Cancer Monoclonal Antibodies by a Phage-Displayed Single-Chain Variable Fragment Library Several monoclonal antibodies (McAbs) have been developed that show high sensitivity and specificity to gastric cancer and colorectal cancer. However, few of the antigens recognized by these antibodies have been identified. The authors now report the selection of anti-idiotype (anti-id) antibodies of MGb1 McAb against gastric cancer and MC5 McAb against colorectal cancer using phage-displayed single-chain variable fragment (ScFv) libraries. After purification, the anti-id antibodies were approximately 30 kd and could be recognized by MGb1/MC5 McAb. Anti-id antibodies significantly blocked the binding of MGb1 and MC5 to gastric cancer/colorectal cancer cells, respectively, suggesting that the antibodies were specific to MGb1 and MC5. Antibodies against gastric and colorectal cancer could be... Proteins May Predict Spread of Colon Cancer Discovery could lead to blood test that would aid prevention efforts, scientist says
Source: HealthDay
Related MedlinePlus Page: Colorectal Cancer (Source: MedlinePlus Health News) Recentin Did Not Meet Primary Endpoint in Horizon III Study in Metastatic Colorectal Cancer This study,... (Source: Drugs.com - Clinical Trials) Funny Name, Serious Goals for Colon Cancer Awareness March is Colon Cancer Awareness month. Raising awareness of this disease is so vitally important.
Colon cancer is one of the most preventable cancers, yet nearly 50,000 Americans lose their lives to colon cancer every year in the United States. It is the second leading cause of cancer deaths in the US.
The Undy 5000
The Colon Cancer Alliance (CCA) is doing their part to raise awareness and funds to fight colon cancer. CCA has created a series of running races called The Undy 5000. In a funny play on words, each race is referred to as "a brief run to fight colon cancer." Each race is 5 kilometers (3.1 miles) in length, which is 5000 meters.
Cancer-specific races, walks, and other events are a successful and valuable way to raise awareness and funds to fight cancer. The Undy 5000 colon cance...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> RECENTIN Did Not Meet Primary Endpoint In Horizon III Study In Metastatic Colorectal Cancer AstraZeneca recently announced the top-line results of a Phase II/III study evaluating RECENTIN (cediranib) compared with Avastin (bevacizumab) in patients with first-line metastatic colorectal cancer (mCRC). (Source: Pharmaceutical Online News) Colorectal Cancer In China The incidence of colorectal cancer (CRC) in China is lower than that in the west countries, but has increased in recent years and become a substantial cancer burden in China, particularly in the more developed areas. Some studies have reported changes in the characteristics of CRC in China. However, due to a lack of an effective nation-wide surveillance system, there has been little information available on the relationship between CRC and geographical environment and economic status in China... (Source: Health News from Medical News Today) Working outdoors reduces cancer risk Research shows vitamin D, produced by skin when exposed to ultraviolet light, associated with reduced rate of renal cancerMen who work outdoors, enabling their bodies to create vitamins through exposure to sunlight, have a reduced risk of kidney cancer, researchers said today.In the largest study of its kind, scientists found that vitamin D ? produced by the skin when exposed to ultraviolet light ? was associated with a reduced rate of renal cancer of up to 73% among men.However, the study, published by the American Cancer Society, found that the reduced risk only applied to men ? there was no drop in renal cancer among the women studied who worked outdoors.The researchers, from the National Cancer Institute in the US, said the study of 2,500 workers in central Europe supported emerg... Obesity Associated With Risk Of Colorectal Tumors Without Microsatellite Instability This study was undertaken because little is know about the associations between body mass index and adult weight gain and the risk of colorectal cancer overall and by tumor MSI status. Peter T. Campbell, Ph.D... (Source: Health News from Medical News Today) Obesity Associated With Risk Of Colorectal Tumors Without Microsatellite Instability The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability (MSI), a common condition in most colorectal cancers, according to a new study published online March 8 in the Journal of the National Cancer Institute... (Source: Obesity / Weight Loss / Fitness News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Physicians Come Together On National Colorectal Cancer Awareness And Screening Day Colorectal cancer (CRC) is the third leading cause of cancer death among men and women nationwide, yet only half of people who need CRC screening receive it. The American Gastroenterological Association (AGA) Institute is working to educate patients about the importance of screening and to encourage everyone age 50 and older to get screened for CRC. Recognizing that those without insurance have limited access to screening, gastroenterologists and physicians throughout the country have established free CRC screening programs for the uninsured... (Source: Health News from Medical News Today) Elderly patients aggressively over-treated with pharmaceuticals (NaturalNews) Researchers from the Cochrane Collaboration research group have determined that seniors over the age of 80 are being given too many drugs and in too high of doses. Particularly with high blood pressure, doctors are too aggressively treating the elderly with pharmaceuticals which is doing them more harm than good.According to the U.S. Centers for Disease Control and Prevention (CDC), nearly a quarter of all Americans between 20 and 75 have hypertension while roughly 70 percent of those over 75 have it.The conventional approach to treating high blood pressure is to prescribe a variety of drugs that, together, doctors hope will achieve a target of 140/90 mmHg. However after scouring several studies to see if such treatments are actually working, Dr. James Wright, head of Cochran... Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility Authors: D Krndija, H Schmid, J-L Eismann, U Lother, G Adler, F Oswald, T Seufferlein
& G von Wichert (Source: Oncogene) Prevent Cancer Foundation Promotes Colon Cancer Awareness Month In honor of March being Colon Cancer Awareness Month, the Prevent Cancer Foundation is kicking off a tour of their Cancer Super Colon educational program.
This innovative program uses a large model of the colon to raise awareness of colon cancer and educate people about colon health. People can literally "tour the colon", by walking through the life-size, medically accurate colon model.
Nearly two dozen Super Colon educational events are taking place throughout the US from now through October 2010. The tour is showing up all across the country, from California, to South Dakota, Texas, Florida, Michigan, and places in between.
Visit the Prevent Cancer Foundation Super Colon Website to find an event near you and for more information.
Prevent Cancer Foundation Promotes Colon Cancer Awareness ... Association between weight, colorectal cancer risk varied by microsatellite stability status (Source: HemOncToday.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer. Authors: Guiu B, Vincent J, Guiu S, Ladoire S, Ortega-Deballon P, Cercueil JP, Chauffert B, Ghiringhelli F
Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper... Blocking effects of siRNA on VEGF expression in human colorectal cancer cells. CONCLUSION: VEGF, FLT-1 and FLK-1 are associated with colorectal carcinogenesis. siRNA silencing of the VEGF gene suppresses proliferation, and induces apoptosis in HCT116 cells. The results suggest that VEGF may be a new gene therapy target for colorectal cancer.
PMID: 20205278 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG) Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases Conclusions:
This study describes cellular and macromolecular changes contributing to immunological escape mechanisms during metastatic growth in a colorectal liver metastases mouse model simulating the situation in human cancer. (Source: BMC Cancer) Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines Conclusion:
This is the first study providing a simultaneous evaluation of the anti-neoplastic action of TRD across several malignant cell lines. The involvement of ROS and caspase activation was highly variable among the five cell lines, although all were susceptible to TRD induced cell death. Our results indicate, that TRD is likely to provide multifaceted cell death mechanisms leading to a cell line specific diversity. (Source: Journal of Experimental and Clinical Cancer Research) Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53. Authors: Carney BK, Cassimeris L
Stathmin, a microtubule regulatory protein, is overexpressed in many cancers and required for survival of several cancer lines. In a study of breast cancer cell lines, Alli et al. (Oncogene. 26:1003-12) proposed that stathmin is required for survival of cells lacking p53, but this hypothesis was not tested directly. Here we tested their hypothesis by examining cell survival in cells depleted of stathmin, p53 or both proteins. Comparing HCT116 colon cancer cell lines differing in TP53 genotype, stathmin depletion resulted in significant death only in cells lacking p53. As a second experimental system, we compared the effects of stathmin depletion from HeLa cells, which normally lack detectable levels of p53 due to expression of the HPV E6 protein. Stathm...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Selective Suicide Gene Therapy of Colon Cancer Exploiting the Urokinase Plasminogen Activator Receptor Promoter (Source: BioDrugs) Researchers find oncogene is important in pancreatic cancer growth and spread Researchers have found that PKC-iota (PKC-i), an oncogene important in colon and lung cancers, is over-produced in pancreatic cancer and is linked to poor patient survival. They also found that genetically inhibiting PKC-i in laboratory animals led to a significant decrease in pancreatic tumor growth and spread. (Source: ScienceDaily Headlines) A New Indicator Of Poor Prognosis In Node-Negative Colorectal Cancer Patients Tumor budding at the invasive tumor front of colorectal cancer is recognized as an independent prognostic factor significantly related to both lymph node and distant metastasis. Several lines of evidence seem to suggest that tumor buds may, to some extent, represent malignant colorectal cancer stem cells because of their potential for migration and re-differentiation locally and at sites of metastasis... (Source: Health News from Medical News Today) A New Indicator Of Poor Prognosis In Node-Negative Colorectal Cancer Patients Tumor budding at the invasive tumor front of colorectal cancer is recognized as an independent prognostic factor significantly related to both lymph node and distant metastasis... (Source: Stem Cell Research News From Medical News Today) Those Who Have Colonoscopy Performed By GIs Less Likely To Develop Colorectal Cancer Following a negative complete colonoscopy, those who had their colonoscopies at a hospital and had their procedures performed by a non- gastroenterologist may be at a significantly increased risk of developing subsequent colorectal cancer (CRC), according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. (Source: Cancercompass News: Colorectal Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Foxp3 Expression in p53-dependent DNA Damage Responses [Signal Transduction] The forkhead transcription factor, Foxp3, is thought to act as a master regulator that controls (suppresses) expression of the breast cancer oncogenes, SKP2 and HER-2/ErbB2. However, the mechanisms that regulate Foxp3 expression and thereby modulate tumor development remain largely unexplored. Here, we demonstrate that Foxp3 up-regulation requires p53 function, showing that Foxp3 expression is directly regulated by p53 upon DNA damage responses in human breast and colon carcinoma cells. Treatment with the genotoxic agents, doxorubicin or etoposide, induced Foxp3 expression in p53-positive carcinoma cells, but not in cells lacking p53 function. Furthermore, knock down of endogenous wild-type p53 using RNA interference abrogated Foxp3 induction by genotoxic agents, and exogenous expression o... Contrasting US and European approaches to colorectal cancer screening: which is best? In the recent 1–2 decades, we have seen a considerable development in colorectal cancer (CRC) screening modalities and programme implementation, but major challenges remain. While CRC is still the second leading cause of cancer death in both the USA and Europe, there are limited data on the efficacy and effectiveness of all screening modalities except for the faecal occult blood test (FOBT). Newer screening tests, such as faecal immunochemical tests, molecular markers and CT colonography are being introduced and variably adopted, though overall rates of screening are suboptimal. Professional societies and governmental bodies have endorsed screening, though recommended approaches are quite variable, which may help to explain the great variation in screening practices. Unfortunately, q... Low Foxp3 expression in negative sentinel lymph nodes is associated with node metastases in colorectal cancer (Source: Gut) Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer Conclusion
This study provides the first evidence that high VFA independently predicts a poorer outcome in patients given first-line bevacizumab-based treatment for MCC. However, this predictive biomarker needs to be validated in a different dataset. (Source: Gut) CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver Conclusion
CD10 expression in CRC cells abrogates the anti-tumour effect of hepatic MENK by degrading it, which enhances liver metastasis of CD10-positive CRC cells. (Source: Gut)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Body fatness and bevacizumab-based therapy in metastatic colorectal cancer (Source: Gut) Blood Test May Predict Colon Cancer Spread Title: Blood Test May Predict Colon Cancer SpreadCategory: Health NewsCreated: 3/5/2010 10:50:00 AMLast Editorial Review: 3/5/2010 10:50:46 AM (Source: MedicineNet Cancer General) Blood Test May Predict Colon Cancer Spread (Source: eMedicineHealth.com) High weight associated with risk of colorectal tumors without microsatellite instability (Journal of the National Cancer Institute) The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability, a common condition in most colorectal cancers, according to a new study published online March 5 in the Journal of the National Cancer Institute. (Source: EurekAlert! - Medicine and Health) Prevalence and Factors Associated with Colorectal Cancer Screening in Canadian Women Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Panitumumab Expands the Treatment Portfolio for Metastatic Colon Cancer Two large studies presented at GI-ASCO demonstrate that panitumumab confirms a positive outcome in patients with metastatic colon cancer. Dr. John Marshall discusses these practice-changing findings. Medscape Hematology-Oncology (Source: Medscape Today Headlines) Identification of 5 novel genes methylated in breast and other epithelial cancers Conclusion:
The combination of the MIRA assay with CpG island arrays is a very useful technique for identifying epigenetically inactivated genes in cancer genomes and can provide molecular markers for early cancer diagnosis, prognosis and epigenetic therapy. (Source: Molecular Cancer) Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice Conclusion:
These results indicate that TRPV1 and TRPA1 could contribute to the development of thermal hyperalgesia and mechanical allodynia following cisplatin-induced painful neuropathy but that TRPV1 has a crucial role in cisplatin-induced thermal hyperalgesia in vivo. (Source: BioMed Central) Research from University Of Pennsylvania Provides New Data On Colon Cancer According to a study from the United States, It has been observed that survival after colorectal cancer resection is longer in women than men. The majority of these studies are in non-U.S. (Source: Cancercompass News: Colorectal Cancer) Oxaliplatin and capecitabine in the treatment of patients with recurrent or refractory carcinoma of unknown primary site Despite the widespread use of oxaliplatin-based regimens for colorectal and other gastrointestinal cancers, there is surprisingly little information regarding their empiric use for the treatment of carcinoma of unknown primary site (CUP). In the current study, the combination of oxaliplatin and capecitabine in patients with recurrent and refractory CUP was examined.Patients with CUP who had received at least 1 previous chemotherapy regimen were treated with oxaliplatin (130 mg/m2 intravenously on Day 1) and capecitabine (1000 mg/m2 orally twice daily on Days 1-14). Treatment cycles were repeated every 21 days. Patients with objective response or stable disease after 2 cycles continued treatment for 6 cycles or until disease progression.Nine of 48 patients (19%) had objective responses to t...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Structure elucidation of new oleanane-type glycosides from three species of Acanthophyllum. Authors: Timité G, Mitaine-Offer AC, Miyamoto T, Ramezani M, Rustaiyan A, Mirjolet JF, Duchamp O, Lacaille-Dubois MA
From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23-O-beta-D-galactopyranosylgypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (1) and gypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (2). The cytotoxicity of several of these saponins was evaluate... Efficient co-transduction of adenoviral vectors encoding carcinoembryonic antigen and survivin into dendritic cells by the CAR-TAT adaptor molecule enhance antitumor immunity in a murine colorectal cancer model. Authors: Kim HS, Kim CH, Park MY, Park JS, Park HM, Sohn HJ, Kim HJ, Kim SG, Oh ST, Kim TG
Because multiple tumor antigens, including carcinoembryonic antigen (CEA) and survivin (SVV), have been frequently observed in human colorectal cancer, we investigated whether the expression of both CEA and SVV by co-transduction of adenovirus vectors into dendritic cells (DC) could improve antitumor immunity in a murine colorectal cancer model. The adaptor fusion protein of Coxsackie and adenovirus receptor and TAT-protein transduction domain (CAR-TAT) enhanced co-transduction of adenovirus vectors encoding CEA (AdCEA) and SVV (AdSVV) into DCs, and increased antitumor immunity. DCs expressing both CEA and SVV in the presence of CAR-TAT (DC-AdCEA/AdSVV+CAR-TAT) induced T-cell responses specific f... MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues. Authors: Okudaira K, Kakar S, Cun L, Choi E, Wu Decamillis R, Miura S, Sleisenger MH, Kim YS, Deng G
Abundant mucin production and MUC2 expression is the key feature of mucinous colorectal cancer (CRC). Although MUC2 gene methylation has been thought to play an important role in loss of MUC2 expression, the tissues are difficult to analyze because of the cellular heterogeneity of tissue samples. In the present study, we determined the role of region-specific methylation in the MUC2 promoter in MUC2 expression in CRC. Additionally, we optimized the conditions for quantification of methylation analysis in mucinous and non-mucinous CRC tissues. We identified two regions in MUC2 promoter, region A (-289 and -274) and region C (-193 and -160), that correlated with loss of MUC2 expression by... Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Authors: Lee HY, Crawley S, Hokari R, Kwon S, Kim YS
MUC2 is a major secretory mucin normally expressed by goblet cells of the intestine, but is aberrantly expressed in colonic neoplasia. Bile acids have been implicated in colorectal carcinogenesis and, therefore, we sought to determine the effects of bile acids on MUC2 expression and regulation in colon cancer cells. Since deoxycholic acid (DCA), a secondary bile acid, has been reported to be a potent mucin secretagogue and tumor promoter, DCA-treated HM3 colon cancer cells were analyzed using promoter-reporter assays of the 5' flanking region of the MUC2 gene. Chemical inhibitors, mutant reporter constructs and EMSA showed that DCA upregulates MUC2 transcription via multiple pathways involving activation of EGFR/PKC/Ras/Raf-1/MEK1/ER... Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells. Authors: Saidou Balde el-H, Mégalizzi V, Cao M, Angenot L, Kiss R, Van Damme M, Frederich M
Isostrychnopentamine (ISP) is an indolomonoter-penic alkaloid that is present in the leaves of Strychnos usambarensis, an East African small tree. We have reported previously pro-apoptotic effects induced in vitro by ISP in the human HCT-116 colon cancer cell line, a model that displays relative sensitivity to apoptosis. In the present study, we observed that the in vitro growth inhibitory activities of ISP are similar in cancer cells that display sensitivity versus resistance to apoptosis. We made use of the U373 glioblastoma and the A549 non-small cell lung cancer (NSCLC) cell lines as models relatively resistant to apoptosis, and the human PC-3 prostate cancer cell line as a model relati...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation. Authors: Um HJ, Bae JH, Park JW, Suh H, Jeong NY, Yoo YH, Kwon TK
Since resveratrol (3,4',5 tri-hydroxystilbene), which has been shown to inhibit multistage carcinogenesis, is not a potent cytotoxic compound, several studies were undertaken to obtain synthetic analogues of resveratrol with potent activity. We previously reported that a resveratrol derivative HS-1793 exhibits stronger antitumor effects than resveratrol in several cancer cell types. The present study was undertaken to reveal precise mechanism by which HS-1793 induces cell death. The induction of CCAAT/enhancer-binding protein-homologous protein (CHOP) and glucose-regulated protein (GRP)-78, and ER stress-specific XBP1 splicing were found in HT29 human colon carcinoma cells treated with resveratrol. Conversely, these mani... Blood Test May Predict Colon Cancer Spread A blood test may soon be able to predict which colon cancers are likely to spread to other parts of the body, according to a new study. (Source: WebMD Health) MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway Biological Chemistry 391 (2/3): 171-180 Abstract A central point of regulation in the Wnt/?-catenin signalling pathway is the formation of the ?-catenin destruction complex. Axin1, an essential negative regulator of Wnt signalling, serves as a scaffold within this complex and is critical for rapid turnover of ?-catenin. To examine the mechanism by which Wnt signalling disables the destruction complex, we used an immunoprecipitation-coupled proteomics approach to identify novel endogenous binding partners of Axin1. We found mitogen-activated protein kinase kinase kinase 1 (MAP3K1) as an Axin1 interactor in Ls174T colorectal cancer (CRC) cells. Importantly, confirmation of this interaction in HEK293T cells indicated that the Axin1-MAP3K1 interaction is induced and modulated by Wnt stimula... Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM RecQ helicase family members are involved in multiple DNA repair pathways, protecting the genome from incorrect recombination during mitosis and maintaining its stability. Deficiencies in genes encoding the RecQ helicases WRN and BLM lead to rare autosomal recessive diseases, Werner and Bloom syndromes, which have been implicated in early onset of aging, and predisposition to various types of cancer. We investigated associations of WRN, BLM and BLM-associated protein (BLAP75/RMI1) gene polymorphisms and risk of colorectal cancer (CRC), genotyping WRN V114I (rs2230009), WRN L1074F (rs2725362), WRN C1367R (rs1346044), RMI1 S455N (rs1982151) and BLM P868L (rs11852361). A large population-based case–control study, including 1795 CRC cases and 1805 controls, found no evidence for an assoc... Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r2 cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whe...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype A subset of colorectal cancers (CRCs) show simultaneous methylation of multiple genes; these tumors have the CpG island methylator phenotype (CIMP). CRCs with CIMP show a specific pattern of genetic alterations, including a high frequency of BRAF mutations and a low frequency of p53 mutations. We therefore hypothesized that genes inactivated by DNA methylation are involved in the BRAF- and p53-signaling pathways. Among those, we examined the epigenetic inactivation of insulin-like growth factor-binding protein 7 (IGFBP7) expression in CRCs. We found that in CRC cell lines, the silencing of IGFBP7 expression was correlated with high levels of DNA methylation and low levels of histone H3K4 methylation. Luciferase and chromatin immunoprecipitation assays in unmethylated cells revealed that p5... Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer H19 is an imprinted oncofetal non-coding RNA recently shown to be the precursor of miR-675. The pathophysiological roles of H19 and its mature product miR-675 to carcinogenesis have, however, not been defined. By quantitative reverse transcription–polymerase chain reaction, both H19 and miR-675 were found to be upregulated in human colon cancer cell lines and primary human colorectal cancer (CRC) tissues compared with adjacent non-cancerous tissues. Subsequently, the tumor suppressor retinoblastoma (RB) was confirmed to be a direct target of miR-675 as the microRNA suppressed the activity of the luciferase reporter carrying the 3'-untranslated region of RB messenger RNA that contains the miR-675-binding site. Suppression of miR-675 by transfection with anti-miR-675 increased RB expre... March Is National Colorectal Cancer Awareness Month Source: Centers for Disease Control and Prevention
Related MedlinePlus Page: Colorectal Cancer (Source: MedlinePlus Health News) Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation. Authors: Kim WJ, Lee SJ, Choi YD, Moon SK
Decursin, a pyranocoumarin isolated from the Korean Angelica gigas root, has demonstrated anti-cancer properties. In the present study, we found that decursin inhibited cell viability in cultured human urinary bladder cancer 235J cells and colon cancer HCT116 cells. The inhibited proliferation was due to apoptotic induction, because both cells treated with decursin dose-dependently showed a sub-G1 phase accumulation and an increased cytoplasmic DNA-histone complex. Cell death caused by decursin was also associated with the down-regulation of anti-apoptotic factor Bcl-2 and the up-regulation of pro-apoptotic molecules cytochrome c, caspase 3 and Bax. Treatment of both types of cancer cells with decursin resulted in G1-phase cell cycle arrest, as... A new indicator of poor prognosis in node-negative colorectal cancer patients (World Journal of Gastroenterology) Tumor buds are single cells or clusters of up to five cells at the invasive tumor front of colorectal tumors which are important for patient outcome and hypothesized to have stem-cell like properties. A research group in Switzerland has investigated the expression of putative cancer stem cell markers in tumor buds of patients with colorectal cancer identifying expression of ABCG5 as a frequent event associated with poor prognosis. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Colon Cancer Quiz How much do you know about colon cancer? Your life could depend on separating factual information from myth. Test your knowledge and then test your family and friends. Quiz prepared by Dr. Waqar Qureshi Professor of Medicine, Baylor College of Medicine Chief of Endoscopy, Baylor Clinic Colorectal cancer is the third most common cancer and third leading cause of death among men and women. True: If undetected, colorectal cancer can penetrate the colon walls and spread to nearby lymph nodes, blood vessels or organs. Without early detection and treatment, the prognosis can be deadly. Colorectal cancer is almost 100% preventable. True: Understanding your risk factors and being screened regularly allows doctors to prevent colon cancer or catch the disease early enough to stop it from spreading. ... A new indicator of poor prognosis in node-negative colorectal cancer patients Tumor buds are single cells or clusters of up to five cells at the invasive tumor front of colorectal tumors which are important for patient outcome and hypothesized to have stem-cell like properties. A research group in Switzerland has investigated the expression of putative cancer stem cell markers in tumor buds of patients with colorectal cancer identifying expression of ABCG5 as a frequent event associated with poor prognosis. (Source: ScienceDaily Headlines) Physicians come together on National Colorectal Cancer Awareness and Screening Day (American Gastroenterological Association) Colorectal cancer (CRC) is the third leading cause of cancer death among men and women nationwide, yet only half of people who need CRC screening receive it. The American Gastroenterological Association Institute is working to educate patients about the importance of screening and to encourage everyone age 50 and older to get screened for CRC. (Source: EurekAlert! - Medicine and Health) Colorectal cancer in China (World Journal of Gastroenterology) A research team from China gained a broader picture of colorectal cancer (CRC) in Guangdong Province and provided important information on the changing epidemiology of this disease over a period of 20 years. They found that the hospitalization rate for CRC has increased over the past 20 years in Guangdong. The characteristics of CRC are different in the five hospitals located in the four different geographic areas. (Source: EurekAlert! - Medicine and Health) Objective burden, resources, and other stressors among informal cancer caregivers: a hidden quality issue? Conclusions: Much assistance for cancer patients is delivered in the home by informal caregivers, often without desired training, with a significant minority having limited resources and high additional demands. Future research should explore the potentially high yield of addressing caregiver needs in improving quality of cancer care and both survivors' and caregivers' outcomes. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Obesity and Receipt of Clinical Preventive Services in Veterans. Authors: Yancy WS, McDuffie JR, Stechuchak KM, Olsen MK, Oddone EZ, Kinsinger LS, Datta SK, Fisher DA, Krause KM, Ostbye T
Although obese individuals utilize health care at higher rates than their normal weight counterparts, they may be less likely to receive certain preventive services. We conducted a retrospective cohort study of veterans with visits to 136 national Veterans Affairs (VA) outpatient clinics in the United States in the year 2000. The cohort included 1,699,219 patients: 94% men, 48% white, and 76% overweight or obese. Overweight and obese patients had higher adjusted odds of receiving each of the targeted clinical preventive services as recommended over 5 years compared with normal weight patients. The odds for receiving vaccinations increased linearly with BMI category... Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer. Authors: Neudecker J, Klein F, Bittner R, Carus T, Stroux A, Schwenk W,
The original article to which this Corrigendum refers was published in British Journal of Surgery 2009; 96: 1458-1467.
PMID: 20205211 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery) The Relationship Between Mental and Physical Health People with depression often have worse physical health, as well as worse self-perceived health, than those without depression.
Depression and other physical health conditions have separate but additive effects on well-being. For example, the combination of heart disease and depression can cause twice the reduction in social interaction than either condition alone.
Patients with both depression and physical health problems are at particular risk: The physical problem can complicate depression’s assessment and treatment by masking or mimicking its symptoms.
It can work the other way as well. People with any chronic physical disease tend to feel more psychological distress than do healthy people. Poor physical health brings an increased risk of depression, as do the social and relati... Virtual colonoscopy: good enough for the president but not the American public? On Feb. 28 President Obama was screened for colorectal cancer using CT colonography. The results from this exam, also called virtual colonoscopy, along with those from the rest of the president?s annual physical, which was done at the National Naval Medical Center in Bethesda, described the president as ?fit for duty.? (Source: Diagnostic Imaging) Latest Advances In Minimally Invasive Medicine Featured At Society Of Interventional Radiology Meeting March 13-18 In Tampa, Fla. The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13 -18 at the Tampa Convention Center. More than 5,000 physicians, scientists and allied health professionals are expected to attend this premier IR event... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Latest Advances In Minimally Invasive Medicine Featured At Society Of Interventional Radiology Meeting March 13-18 In Tampa, Fla. The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13 -18 at the Tampa Convention Center... (Source: Cancer / Oncology News From Medical News Today) Virtual colonoscopy: good enough for the president but not the American public? On Feb. 28 President Obama was screened for colorectal cancer using CT colonography. The results from this exam, also called virtual colonoscopy, along with those from the rest of the president?s annual physical, which was done at the National Naval Medical Center in Bethesda, described the president as ?fit for duty.? (Source: Cancer Network) The Right Colorectal Cancer Test For The Right Patient Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them... (Source: Public Health News From Medical News Today) The Right Colorectal Cancer Test For The Right Patient Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them. Physician experts from the American College of Gastroenterology are available to comment and help provide perspective on the many options for colorectal cancer screening during March Colorectal Cancer Awareness Month... (Source: Health News from Medical News Today) The Right Colorectal Cancer Test For The Right Patient Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them. Physician experts from the American College of Gastroenterology are available to comment and help provide perspective on the many options for colorectal cancer screening during March Colorectal Cancer Awareness Month... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> The Right Colorectal Cancer Test For The Right Patient Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them... (Source: Cancer / Oncology News From Medical News Today) Out-of-pocket payment and cost-effectiveness of XELOX and XELOX plus bevacizumab therapy: from the perspective of metastatic colorectal cancer patients in Japan Conclusions We clarified the out-of-pocket payment and cost-effectiveness of chemotherapy of MCRC patients in Japan. Our previous survey
shows it is highly possible that many patients prefer to pay that incremental out-of-pocket payment to gain one additional
QAPFS year. However, our cost-effectiveness analysis was not conducted from the perspective of society or healthcare payers.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0045-xAuthors
Takeru Shiroiwa, The University of Tokyo Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences Yakugaku-toshokan 4F, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 JapanTakashi Fukuda, The University of Tokyo Department of Health Economics and Epidemiology Research, School of Pu... A New Era in Defining Indications for Resectability of Colorectal Cancer Liver Metastases Abstract Recent developments have expanded the criteria for resectability of colorectal cancer liver metastases (CRCLM). Pre-hepatectomy
chemotherapy, portal venous occlusion, and two-stage hepatectomy may enable complete lesion extirpation while maintaining
a liver remnant with suitable size, biliary drainage, and vascular inflow and outflow to provide sufficient hepatic function
after resection. Enthusiasm for chemotherapy must be tempered by the potential deleterious effects on the non-tumor-bearing
liver, which may render some patients unresectable. The presence of extrahepatic metastatic disease, multiple CRCLM, and the
inability to envision a 1-cm negative resection margin no longer are absolute contraindications for surgical extirpation.
Resection of CRCLM in the pr... Laparoscopic Total Gastrectomy and D2 Lymphadenectomy Conclusions Thanks to laparoscopy, a meticulous lymphadenectomy can be performed under excellent view. Advantages, besides rapid recovery
of bowel function, include short hospitalization and better cosmesis. Circular stapler esophagojejunostomy can easily be performed
by insertion of the anvil transabdominally.
Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-010-0936-0Authors
Giovanni Dapri, Saint-Pierre University Hospital Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery Brussels BelgiumJacques Himpens, Saint-Pierre University Hospital Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery Brussels BelgiumGuy-Bernard Cadière, Saint-Pierre University Hospital Department of Gast... Systemic Inflammatory Response Associated with Distant Metastasis of T1 or T2 Colorectal Cancer Conclusions CRP and GPS are associated with distant metastasis of T1 or T2 colorectal cancer. Because of the small number of patients
with stage IV disease (n = 4), a multi-center retrospective study is needed to confirm these findings.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1159-8Authors
Mitsuru Ishizuka, Dokkyo Medical University Department of Gastroenterological Surgery 880 Kitakobayashi Mibu, Tochigi 321-0293 JapanHitoshi Nagata, Dokkyo Medical University Department of Gastroenterological Surgery 880 Kitakobayashi Mibu, Tochigi 321-0293 JapanKazutoshi Takagi, Dokkyo Medical University Department of Gastroenterological Surgery 880 Kitakobayashi Mibu, Tochigi 321-0293 JapanKeiichi Kubota, Dokkyo Medical University Depa...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Sociodemographic Characteristics Are Related To A Patient's Willingness To Participate In Cancer Screenings This study appears in the March issue of the Journal of the National Medical Association. Prior studies have shown that screenings are crucial in identifying cancer in its early stages and minorities have lower screening rates for certain types of cancer, such as cervical and colorectal cancer... (Source: Health News from Medical News Today) Researchers Fishing For Cancer Cure Discover Active DHA Derivatives The next treatment for cancer might come from fish says a new research report published in the March 2010 print edition of the FASEB Journal (http://www.fasebj.org). In the report, scientists show that the omega-3 fatty acid, "docosahexaenoic acid" or "DHA," and its derivatives in the body kill neuroblastoma cancer cells. This discovery could lead to new treatments for a wide range of cancers, including neuroblastoma, medulloblastoma, colon, breast, and prostate cancers, among others... (Source: Health News from Medical News Today) Natural compound in marine sponges could halt cancer metastasis (NaturalNews) A research team at Sanford-Burnham Medical Research has discovered a natural compound found in marine sponges that reduces the movement of cancer cells. This could be an important breakthrough in stopping the often deadly spread of cancer throughout the body -- a process known as metastasis. What's more, the compound (dubbed sceptrin) is virtually non-toxic.The research, just published in the American Chemical Society (ACS) journal Chemical Biology, was headed by Sanford-Burnham scientist Kristiina Vuori, M.D., PhD, in collaboration with Phil S. Baran, Ph.D., of the Scripps Research Institute. The scientists tested the impact of sceptrin on multiple tumor cell types, including cervical, breast and lung cancer cells.To encourage cancer cells to behave like those that spread in... New biomarkers for predicting the spread of colon cancer (American Chemical Society) Scientists in China are reporting discovery of two proteins present in the blood of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. Their study is in ACS' Journal of Proteome Research, a monthly publication. (Source: EurekAlert! - Biology) Psychological distress and quality of life of partners of individuals with familial adenomatous polyposis Conclusions: Clinicians should be particularly alert for heightened distress levels in partners of patients who are themselves distressed, and among those with children. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Eat Colorfully To Prevent Colon Cancer The message is a simple one: Colorectal cancer is preventable, treatable and beatable IF you get screened to catch the disease early, and if you eat a rainbow of foods rich in cancer- fighting nutrients and fiber and lead a lively lifestyle, incorporating exercise and a positive outlook. (Source: Cancercompass News: Colorectal Cancer) Dress in Blue Day Aims To Raise Colon Cancer Awareness On Friday, March 5, 2010, the Colon Cancer Alliance (CCA) is asking local communities, corporations and the general public to support awareness of colorectal cancer by Dressing in Blue.
The CCA hopes Dress in Blue Day will help start a conversation about colon cancer. The goal is to spread awareness about colon cancer screening, which can reduce the risk of this disease.
Why Blue?
Dress in Blue Day is designed to be similar to breast cancer's pink ribbon approach. Just like the pink ribbon campaign to raise breast cancer awareness, the blue star symbol will serves as a year-round reminder of the battle against colon cancer.
Why is Dress in Blue Day So Important?
Colon Cancer is a highly preventable, but rarely discussed disease. Colon cancer claims the lives of nearly 50,000 Americans ever... Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8(+) T-cells. Authors: Crawley AM, Vranjkovic A, Young C, Angel JB
Signalling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer. Many IL-2Rgamma-sharing (gamma(C)) cytokines decrease CD127 expression on CD4(+) and CD8(+) T-cells in mice (IL-2, -4, -7, -15) and in humans (IL-2, -7) suggesting a common function. IL-4 is of particular interest as it is upregulated in HIV infection and in thyroid and colon cancers. The role of IL-4 in regulating CD127 expression and IL-7 activity in human thymocytes and mature CD8(+) T-cells is unknown andwas therefore investigated. IL-4 decreased CD127 expression on all thymocyte subsets tested a... Role of fatty acid chain length on the induction of apoptosis by newly synthesized catechin derivatives. In this study we investigated whether the chemical modification of (-)-Epigallocatechin gallate (EGCG) could enhance its apoptosis activity. We found that one of the catechin conjugated with capric acid [(2R,3S)-3',4',5,7-Tetrahydroxyflavan-3-yl decanoate; catechin-C10] was most potent to induce apoptosis in U937 cells. C10 treatment resulted in a significant increase in reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) loss, cytochrome c release caspase-9 and caspase-3 activation. In addition to this C10 also activated extrinsic pathway significantly as evident by time-dependent increase in Fas expression and caspase-8 activity. C10 mediated cleavage of Bid may be an important event for cross talk between intrinsic and extrinsic signaling. Moreover, pre-treat... Widespread and tissue specific age-related DNA methylation changes in mice [LETTERS] Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may be a risk factor for human colon cancer. It is not known whether this age-related DNA methylation phenomenon is specific to human tissues. We performed comprehensive DNA methylation profiling of promoter regions in aging mouse intestine using methylated CpG island amplification in combination with microarray analysis. By comparing C57BL/6 mice at 3-mo-old versus 35-mo-old for 3627 detectable autosomal genes, we found 774 (21%) that showed increased methylation and 466 (13%) that showed decreased methylation. We used pyrosequencing to quantitatively validate the microarray data and confirmed linear age-related methyl...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Copy number abnormalities in sporadic canine colorectal cancers [LETTERS] Human colorectal cancer (CRC) is one of the better-understood systems for studying the genetics of cancer initiation and progression. To develop a cross-species comparison strategy for identifying CRC causative gene or genomic alterations, we performed array comparative genomic hybridization (aCGH) to investigate copy number abnormalities (CNAs), one of the most prominent lesion types reported for human CRCs, in 10 spontaneously occurring canine CRCs. The results revealed for the first time a strong degree of genetic homology between sporadic canine and human CRCs. First, we saw that between 5% and 22% of the canine genome was amplified/deleted in these tumors, and that, reminiscent of human CRCs, the total altered sequences directly correlated to the tumor's progression stage, origin, and... Five common cancers in iran. Authors: Kolahdoozan S, Sadjadi A, Radmard AR, Khademi H
Iran as a developing nation is in epidemiological transition from communicable to non-communicable diseases. Although, cancer is the third cause of death in Iran, it;s mortality are on the rise during recent decades. This mini-review was carried out to provide a general viewpoint on common cancers incidence in Iran and to explain incidental differences that may help us to establish early detection programs and investigate population risk factors. A detailed PubMed, Scopus and Google scholar search were made from 2000 to 2009. The basic inclusion criteria were all relevant studies focused on cancer epidemiological data from Iran. Overall age-standard incidence rate per 100 000 population according to primary site is 110.43 in male... Study of 5HT3 and HT4 Receptor Expression in HT29 Cell Line and Human Colon Adenocarcinoma Tissues. CONCLUSION: The results indicate which 5HT3 and 5HT4 receptors are significantly expressed in both colon cancer tissue and the HT29 cell line. Expression for the 5HT3 receptor is more potent. Furthermore, 5HT plays a mitogenic role in colon cancer cells and antagonists of 5HT3, and 5HT4 receptors can inhibit cancer cell growth.
PMID: 20187666 [PubMed - in process] (Source: Archives of Iranian Medicine) Role of RNA-Binding Proteins in Colorectal Carcinogenesis Abstract RNA-binding proteins (RBPs) play key roles in the posttranscriptional regulation of gene expression. RBPs control various
posttranscriptional events, including splicing, polyadenylation, mRNA stability, transport, and translation. It is becoming
apparent that RBPs play a significant role in pathophysiologic conditions such as inflammation and cancer. More importantly,
we and others have begun dissecting the role of mRNA stability and translation in regulating gene expression, dysregulation
of which has serious consequences for the fate of the cell. In this article, we discuss this emerging area of posttranscriptional
gene regulation and the role of RBPs in the aberrant expression of proteins in tumorigenesis.
Content Type Journal ArticleDOI 10.1007/s11888-010-... Metastasectomy of Combined Liver and Lung Colorectal Cancer Metastases Abstract The liver is the exclusive site of metastasis in approximately 30% to 50% of patients with stage IV colorectal cancer, whereas
lung metastasis occurs in 10% to 20% of patients. No single study has specifically addressed the predictors of survival after
resection of synchronously diagnosed lung and liver metastases. Patients who undergo metastasectomy for simultaneous lung
and liver metastases have a reported 5-year survival rate of approximately 40%. The prognostic significance of simultaneous
presentation of lung and liver metastases (versus temporally separated presentations) is unclear. Other proposed predictors
include short disease-free interval, patient age, and lung as first metastatic site. A paucity of data has led to a clinically
driven treatment approac...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with ?-catenin Conclusions The results suggest that up-regulation of Lgr5 expression, especially in female patients, may play an important role in colorectal
carcinogenesis, probably through the WNT/?-catenin pathway, but not involve the progression of the CRC.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0903-zAuthors
Xiang-Shan Fan, Nanjing University Medical School Department of Pathology, Affiliated Nanjing Drum Tower Hospital Nanjing Jiangsu People?s Republic of ChinaHong-Yan Wu, Nanjing University Medical School Department of Pathology, Affiliated Nanjing Drum Tower Hospital Nanjing Jiangsu People?s Republic of ChinaHui-Ping Yu, Nanjing University Medical School Department of Pathology, Affiliated Nanjing Drum Tower Hospital Nanjing Jiangsu... A new sphincter-preserving operation for low rectal cancer: ultralow anterior resection and colorectal/coloanal anastomosis by supporting bundling-up method Conclusions Ultralow anterior resection and colorectal/coloanal anastomosis by supporting bundling-up method may be one of the best choices
of sphincter-preserving operation for low rectal cancer.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0908-7Authors
Fanghai Han, First Affiliated Hospital of Sun Yat-sen University Department of Gastrointestinopancreatic Surgery Guangzhou 510080 ChinaHongming Li, First Affiliated Hospital of Sun Yat-sen University Department of Gastrointestinopancreatic Surgery Guangzhou 510080 ChinaDonghua Zheng, First Affiliated Hospital of Sun Yat-sen University Department of Gastrointestinopancreatic Surgery Guangzhou 510080 ChinaHongkai Gao, West China Hospital, Sichuan University Department of General Surgery ... Celsion Plans To Launch Phase II Program To Study ThermoDox(R) In Combination With RFA For Colorectal Liver Metastases Celsion Corporation (Nasdaq: CLSN) announced that it will initiate a Randomized Phase II Study of Lyso-Thermosensitive Liposomal Doxorubicin (ThermoDox®) and Radiofrequency Ablation (RFA) for Colorectal Liver Metastases (CRLM). Dr. Steven K. Libutti, Professor and Vice Chairman, Department of Surgery and Director of the Montefiore-Einstein Center for Cancer Care at the Montefiore Medical Center and Albert Einstein College of Medicine in New York City, will serve as Principal Investigator for the study... (Source: Health News from Medical News Today) Celsion Plans To Launch Phase II Program To Study ThermoDox(R) In Combination With RFA For Colorectal Liver Metastases Celsion Corporation (Nasdaq: CLSN) announced that it will initiate a Randomized Phase II Study of Lyso-Thermosensitive Liposomal Doxorubicin (ThermoDox®) and Radiofrequency Ablation (RFA) for Colorectal Liver Metastases (CRLM). Dr. Steven K... (Source: Liver Disease / Hepatitis News From Medical News Today) Experts call for further research into the relationship between insulin therapy and cancer (Wiley-Blackwell) The benefits of using insulin to treat diabetes far outweigh the risks, but a new review suggests that people with diabetes, particularly type 2 diabetes, may face an increased risk of cancer and that their cancer may be modified by treatment choices. The review showed that: diabetic patients are 30 percent more likely to develop colorectal cancer and have an 82 percent higher risk of pancreatic cancer. Female diabetics face a 20 percent greater risk of breast cancer. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Insulin used to treat diabetes may be linked to increased cancer risk, review suggests The benefits of using insulin to treat diabetes far outweigh the risks, but a new review suggests that people with diabetes, particularly type 2 diabetes, may face an increased risk of cancer and that their cancer may be modified by treatment choices. The review showed that: diabetic patients are 30 percent more likely to develop colorectal cancer and have an 82 percent higher risk of pancreatic cancer. Female diabetics face a 20 percent greater risk of breast cancer. (Source: ScienceDaily Headlines) Society of Interventional Radiology hosts 35th Annual Scientific Meeting (Society of Interventional Radiology) The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13-18 at the Tampa Convention Center. (Source: EurekAlert! - Medicine and Health) Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation Conclusion:
Our results demonstrate that tumoral metabolism of SN38 is affected by PXR and point to potential therapeutic significance of PXR quantification in the prediction of irinotecan response. Furthermore, our observations are pharmacologically relevant since many patients suffering from cancer diseases are often exposed to co-medications, food additives or herbal supplements able to activate PXR. A substantial part of the variability observed among patients might be caused by such interactions. (Source: Molecular Cancer) Preferences for colorectal cancer screening strategies: a discrete choice experiment Authors: L Hol, E W de Bekker-Grob, L van Dam, B Donkers, E J Kuipers, J D F Habbema, E W Steyerberg, M E van Leerdam
& M L Essink-Bot (Source: British Journal of Cancer AOP) Mesalazine Reduces Mutations in Transforming Growth Factor {beta} Receptor II and Activin Type II Receptor by Improvement of Replication Fidelity in Mononucleotide Repeats. CONCLUSIONS: 5-ASA increases replication fidelity in mononucleotide, dinucleotide, and tetranucleotide repeats and reduces mutations in tumor suppressor genes TGFBR2 and ACVR2, a finding that may provoke in vivo studies for the prevention of colorectal cancer in hereditary nonpolyposis colorectal cancer. Clin Cancer Res; 16(6); 1950-6.
PMID: 20197483 [PubMed - as supplied by publisher] (Source: Cell Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth. Authors: Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM
Inhibition of angiopoietin-2 (Ang2) can slow tumor growth, but the underlying mechanism is not fully understood. Because Ang2 is expressed in growing blood vessels and promotes angiogenesis driven by vascular endothelial growth factor (VEGF), we asked whether the antitumor effect of Ang2 inhibition results from reduced sprouting angiogenesis and whether the effect is augmented by inhibition of VEGF from tumor cells. Using Colo205 human colon carcinomas in nude mice as a model, we found that selective inhibition of Ang2 by the peptide-Fc fusion protein L1-7(N) reduced the number of vascular sprouts by 46% and tumor growth by 62% over 26 days. Strikingly, when the Ang2 inhibitor was ... 3-Phosphoinositide-Dependent Protein Kinase-1 Regulates Proliferation and Survival of Cancer Cells with an Activated Mitogen-Activated Protein Kinase Pathway. In this study, we show that the reduction of PDK1 by RNAi in melanoma and colon cancer cell lines activated in the MAPK pathway results in significant cell growth inhibition and apoptosis. Furthermore, PDK1 reduction in tumor cells resulted in impaired PAK kinase signaling, altered actin polymerization, and reduced cell migration. These studies show that PDK1 plays a pivotal role in MAPK and PI3K signaling in tumor cells. Mol Cancer Res; 8(3); 421-32.
PMID: 20197379 [PubMed - as supplied by publisher] (Source: Cell Research) The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status. CONCLUSIONS: In this study, we found a poor prognosis in CIMP-low patients regardless of MSI screening status, and in CIMP-high patients with MSS. Although not consistently statistically significant, these results were consistent in two separate patient groups and emphasize the potential importance of CIMP and MSI status in colorectal cancer research. Clin Cancer Res; 16(6); 1845-55.
PMID: 20197478 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research) Intratumoral as well as peritumoral lymphatic vessel invasion correlates with lymph node metastasis and unfavourable outcome in colorectal cancer Abstract The aim of this study was to assess the intratumoral and peritumoral distribution of lymphatic vessel density (LVD) and lymphatic
vessel invasion (LVI) in colorectal cancer and their relationships with patients? clinicopathological characteristics and
survival. Paraffin sections of 81 primary colorectal cancers were examined by immunohistochemical staining using monoclonal
antibody D2-40. Peritumoral LVD was significantly higher than intratumoral LVD (P = 0.000). Both intratumoral LVD and peritumoral LVD were correlated with the presence of LVI (P = 0.006 and P = 0.003, respectively). LVI, intratumoral LVI and peritumoral LVI were identified, respectively in 38, 28 and 32% of the
samples investigated. Both intratumoral LVI and peritum... Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest Summary We evaluated the combination treatment of ethaselen (BBSKE) as a thioredoxin reductase (TrxR) inhibitor plus cisplatin (CDDP)
on the human colon adenocarcinoma cell line LoVo. Therapeutic effects ranging from nearly additive to clearly synergistic
demonstrated an effective combination, i.e., the cytostatic dose of CDDP could be reduced without a loss in efficacy. To further
investigate the cellular response mechanisms of these favorable outcomes, we analyzed the cell-cycle profiles, mRNA expression
patterns, and protein levels of several key genes after incubation with BBSKE or CDDP separately and in combination. In appropriate
conditions, CDDP induced arrest at the G2/M phase accompanied by the enhanced inhibitory phosphorylation of Cdk1 and the elevated
protein e...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> The duration of functioning of a subcutaneous implantable port for the treatment of hematological tumors: a single institution-based study Conclusion The duration of port functioning in patients with hematological tumors was comparable to that in patients with nonhematological
tumors. The higher rate of BSI in the hematology group was primarily attributable to profound neutropenia.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0039-8Authors
Hitoshi Ohno, Takeda General Hospital Department of Hematology 28-1 Ishida-Moriminami-cho, Fushimi-ku Kyoto 601-1495 JapanChisaki Mizumoto, Takeda General Hospital Department of Hematology 28-1 Ishida-Moriminami-cho, Fushimi-ku Kyoto 601-1495 JapanYoshihiro Otsuki, Takeda General Hospital Department of Hematology 28-1 Ishida-Moriminami-cho, Fushimi-ku Kyoto 601-1495 JapanShigeru Oguma, Takeda General Hospital Department of Hematology 28-... Colon Cancer Alliance Representatives to Ring The NASDAQ Stock Market Closing Bell ADVISORY, March 1, 2010 (GLOBE NEWSWIRE) --
What: (Source: Medical News (via PRIMEZONE)) First Report on Cydonia oblonga Miller Anticancer Potential: Differential Antiproliferative Effect against Human Kidney and Colon Cancer Cells Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry) Medical oncology: IMP3 is a novel prognostic marker for colon cancer Nature Reviews Clinical Oncology 7, 123 (2010). doi:10.1038/nrclinonc.2010.15
Author: Lisa Hutchinson
Colon cancer is one of the leading causes of cancer-related mortality. Previous studies using laser capture microdissection revealed insulin-like growth factor-II mRNA-binding protein 3 (IMP3) was overexpressed in colon cancer compared with normal mucosa, indicating its role as a candidate biomarker. Therefore, Li and coauthors (Source: Nature Clinical Practice Oncology) DNA mismatch repair and adjuvant chemotherapy in sporadic colon cancer Nature Reviews Clinical Oncology 7, 174 (2010). doi:10.1038/nrclinonc.2009.235
Author: Frank A. Sinicrope
Defective DNA mismatch repair (MMR) occurs in approximately 15% of sporadic colorectal cancers (CRCs). Multiple retrospective studies have shown that patients with MMR-deficient CRCs have a more favorable stage-adjusted prognosis compared with those who have MMR-proficient tumors. Evidence also indicates that patients with MMR-deficient colon (Source: Nature Clinical Practice Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Colorectal cancer screening rates rising but still low An NIH panel suggests eliminating financial barriers and implementing interventions to increase screening. (Source: American Medical News - PROFESSION) Gene Signature May Improve Colon Cancer Treatment A gene signature, first identified in mouse colon cancer cells, may help identify patients at risk of colon cancer recurrence, according to a recent study by Vanderbilt-Ingram Cancer Center researchers. The findings, published in the March issue of Gastroenterology, could help personalize treatments for colon cancer - the second leading cause of cancer-related deaths in the United States - by identifying patients most likely to benefit from chemotherapy. In its early stages, colorectal cancer is treated with surgery only... (Source: Health News from Medical News Today) Gene Signature May Improve Colon Cancer Treatment A gene signature, first identified in mouse colon cancer cells, may help identify patients at risk of colon cancer recurrence, according to a recent study by Vanderbilt-Ingram Cancer Center researchers... (Source: Genetics News From Medical News Today) FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth A novel member of the FOX family of transcription factors is implicated in colon tumorigenesis through its ability to restrict expression of the pivotal cell cycle regulator p21WAF1. (Source: Cancer Research)
major salivary gland cancers:
Picture of tumor sizes
Pea, peanut, walnut, and lime show tumor sizes.
Stage I
In stage I, the tumor is in the salivary gland only and is 2 centimeters or smaller.
Stage II
In stage II, the tumor is in the salivary gland only and is larger than 2 centimeters but not larger than 4 centimeters.
Stage III
In stage III, one of the following is true:
* The tumor is not larger than 4 centimeters and has spread to a single lymph node on the same side as the tumor and the lymph node is 3 centimeters or smaller.
* The tumor is larger than 4 centimeters and/or has spread to soft tissue around the affected gland. Cancer may have spread to a single lymph node on the same side as the tumor and the lymph node is 3 centimeters or smaller.
Stage IV
Stage IV is divided into stages IVA, IVB, and IVC as follows:
* Stage IVA:
o The tumor may be any size and may have spread to soft tissue around the affected gland. Cancer has spread to one or more lymph nodes on either or both sides of the body and the lymph nodes are not larger than 6 centimeters; or
o Cancer has spread to the skin, jawbone, ear canal, and/or facial nerve, and may have spread to one or more lymph nodes on either or both sides of the body. The lymph nodes are not larger than 6 centimeters.
* Stage IVB:
o The tumor may be any size and may have spread to soft tissue around the affected gland. Cancer has spread to a lymph node larger than 6 centimeters; or
o Cancer has spread to the base of the skull and/or the carotid artery, and may have spread to one or more lymph nodes of any size on either or both sides of the body.
* Stage IVC:
o The tumor may be any size and may have spread to soft tissue around the affected gland, to the skin, jawbone, ear canal, facial nerve, base of the skull, or carotid artery, or to one or more lymph nodes on either or both sides of the body. Cancer has spread to distant parts of the body.
Salivary gland cancers are also grouped by grade. The grade of a tumor tells how fast the cancer cells are growing, based on how the cells look under a microscope. Low-grade cancers grow more slowly than high- grade cancers.
Minor salivary gland cancers are staged according to where they were first found in the body.
Recurrent salivary gland cancer
Recurrent is cancer that has recurred (come back) after it has been treated. Recurrent may come back in the salivary glands or in other parts of the body.
We strive to provide only quality articles, so if there is a specific topic related to prognosis of salivary gland cancer in cat that you would like us to cover, please contact us at any time.
And again, thank you to those contributing daily to our prognosis of salivary gland cancer in cat website .
A blood test for breast cancer? Researchers hopeful U.S. researchers are working on an experimental DNA test that could pave the way for a simple blood test to detect breast cancer. (Source: CTV Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> 10.03.10: MR contrast agents for diagnosis of breast cancer MR contrast agents for diagnosis of breast cancerBayer starts Phase III study to evaluate efficacy and safety of Gadovist® in magnetic resonance mammographymehr ... (Source: Bayer IR Newsfeed: Events) Challenges in the development of future treatments for breast cancer stem cells Shyam A Patel, Anicia Ndabahaliye, Philip K Lim, et al (Source: Vascular Health and Risk Management) A Third Study Finds Bisphosphonates Reduce Breast Cancer Risk Women who were taking bisphosphonates for osteoporosis had a 30% reduced risk for breast cancer, compared with control subjects not taking these drugs. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines) Microarray analysis of suppression subtracted hybridisation libraries identifies genes associated with breast cancer progression. Conclusions: The combination of subtracted cDNA libraries and microarray analysis has thus identified potential diagnostic/prognostic biomarkers and targets for cancer therapy, which have not been identified from common prognostic gene signatures.
PMID: 20208137 [PubMed - in process] (Source: Cellular Oncology) Why condemn fluoxetine? (Source: BMJ Online First)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Authors' reply (Source: BMJ Online First) TechniScan Teams With Researchers At UC San Diego In Clinical Study With Warm Bath Ultrasound(TM) System TechniScan, Inc. (OTC Bulletin Board: TSNI) ("TechniScan" or the "Company"), a medical device company engaged in the development and commercialization of an automated breast ultrasound imaging system, announced that it has commenced phase two of its grant study at the University of California, San Diego (UCSD) Moores Cancer Center... (Source: Breast Cancer News From Medical News Today) TechniScan Teams With Researchers At UC San Diego In Clinical Study With Warm Bath Ultrasound(TM) System TechniScan, Inc. (OTC Bulletin Board: TSNI) ("TechniScan" or the "Company"), a medical device company engaged in the development and commercialization of an automated breast ultrasound imaging system, announced that it has commenced phase two of its grant study at the University of California, San Diego (UCSD) Moores Cancer Center. TechniScan's Warm Bath Ultrasound (WBU?) system is designed to capture three-dimensional images of the breast as a woman lies prone on a table and state-of-the- art ultrasound technology is used in a warm water tank to capture images of the breast anatomy... (Source: Health News from Medical News Today) Professor Discovers Link Between Low Oxygen Levels In Body And Cancer-Aiding Protein; Could Help Treatments For Retinoblastoma, Breast Cancer What began as research into how diabetics could possibly preserve their eyesight has led to findings that could prolong the vision of children afflicted with retinoblastoma. Dolores Takemoto, a Kansas State University professor of biochemistry who was researching protein kinase C gamma in the lens of the human eye, found her work taking a fascinating turn when she discovered a correlation between the protein Coonexin46 and hypoxia -- a deficiency of oxygen which kills normal tissue cells. According to the data, Coonexin46, or Cx46, appears in the body during these levels of low oxygen... (Source: Health News from Medical News Today) Dependence Receptors : A New Weapon To Inhibit Tumors? The interaction of a ligand (Neurotrophine-3) and its dependence receptor (TrkC) constitutes a novel mechanism for tumor control in pediatric cancers such as neuroblastoma, and may also be important to the inhibition of other cancers such as breast cancer. These findings by a team in the Laboratoire Apoptose, Cancer et Développement (CNRS/Université Lyon 1/Centre de Lutte contre le Cancer Léon Bérard), support the concept put forward several years ago by the same laboratory concerning the design of anti-tumor therapeutic strategies targeting a new type of receptor, the dependence receptor... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> The Side-Out Foundation Hopes To Score Big With Its First Funded Breast Cancer Clinical Trial The Side-Out Foundation, which pairs volleyball enthusiasts with breast cancer researchers, is sponsoring a new clinical trial for up to 25 patients with advanced breast cancer. TGen Drug Development (TD2) will manage this pilot study for the Side-Out Foundation at two locations: TGen Clinical Research Services (TCRS) at Scottsdale Healthcare in Scottsdale, Ariz.; and Fairfax Northern Virginia Hematology Oncology in Fairfax, Va. The clinical trial, which began Feb... (Source: Health News from Medical News Today) Professor Discovers Link Between Low Oxygen Levels In Body And Cancer-Aiding Protein; Could Help Treatments For Retinoblastoma, Breast Cancer What began as research into how diabetics could possibly preserve their eyesight has led to findings that could prolong the vision of children afflicted with retinoblastoma... (Source: Breast Cancer News From Medical News Today) The Side-Out Foundation Hopes To Score Big With Its First Funded Breast Cancer Clinical Trial The Side-Out Foundation, which pairs volleyball enthusiasts with breast cancer researchers, is sponsoring a new clinical trial for up to 25 patients with advanced breast cancer. TGen Drug Development (TD2) will manage this pilot study for the Side-Out Foundation at two locations: TGen Clinical Research Services (TCRS) at Scottsdale Healthcare in Scottsdale, Ariz... (Source: Breast Cancer News From Medical News Today) Dependence Receptors : A New Weapon To Inhibit Tumors? The interaction of a ligand (Neurotrophine-3) and its dependence receptor (TrkC) constitutes a novel mechanism for tumor control in pediatric cancers such as neuroblastoma, and may also be important to the inhibition of other cancers such as breast cancer... (Source: Cancer / Oncology News From Medical News Today) Surgical Biopsies are Not the Standard of Care You've been for your screening mammogram, the radiologist saw something, did more imaging studies and now says you need a biopsy. Sound familiar?
But then the radiologist refers you to a breast surgeon?is this the correct next step? No, not usually, because surgeons do what? Operate, of course! (Source: Breast Cancer Chronicles)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Breast cancer drug fulvestrant appears more effective in the presence of CK8 and CK18 (Indiana University) Women's responsiveness to the second-line breast cancer drug fulvestrant may depend on whether the cancer cells are expressing two key proteins, Indiana University Bloomington scientists report in this month's Cancer Biology & Therapy. (Source: EurekAlert! - Medicine and Health) Breast cancer drug fulvestrant appears more effective in the presence of CK8 and CK18 Women's responsiveness to the second-line breast cancer drug fulvestrant may depend on whether the cancer cells are expressing two key proteins, scientists report. (Source: ScienceDaily Headlines) Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer Background:
The purpose of our study was to compare differences in the prognosis of breast cancer (BC) patients at high (H) risk or intermediate slightly (IS) increased risk based on family history and those without a family history of BC, and to evaluate whether ten-year overall survival can be considered a good indicator of BRCA1 gene mutation.
Methods:
We classified 5923 breast cancer patients registered between 1988 and 2006 at the Department of Oncology and Haematology in Modena, Italy, into one of three different risk categories according to Modena criteria. One thousand eleven patients at H and IS increased risk were tested for BRCA1/2 mutations. The overall survival (OS) and disease free survival (DFS) were the study end-points.
Results:
Eighty BRCA1 carriers were identified. A sta... Yale Study Details How And Why Of BPA's Dangers Exposing a female fetus to a chemical found in plastics causes permanent changes in a daughter's uterus that might result in cancer -- and a research team led by a Yale doctor has figured out why. (Source: Cancercompass News: Breast Cancer) Herbs Give Smaller Portion A Bigger Flavor Want to build a healthier dinner plate? Add more vegetables and cut down on portion sizes of meat and starch, say health experts and nutritionists. The New American Plate section on the American Institute for Cancer Research Web site, www.aicr.org, says to aim for a meal made up of at least two-thirds vegetables, fruits, whole grains or beans and one-third or less animal protein. (Source: Cancercompass News: Breast Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Cheaper Treatments Have Pros And Cons In the past, medical tourists -- those who travel overseas to have procedures done -- typically were wealthy. But with many consumers' budgets strapped and the rising cost of medical care, a growing number of Americans are traveling elsewhere to have operations and procedures in an attempt to save money. (Source: Cancercompass News: Breast Cancer) Doctors, Patients Should Weigh Risks vs. Rewards Of Medical Imaging After an imaging test revealed a small nodule in Dr. Len Lichtenfeld's lung, his doctor ordered a series of CT scans. But Lichtenfeld turned them down. As deputy chief medical officer of the American Cancer Society, Lichtenfeld knew the tiny nodule probably wasn't dangerous and that new research has documented an increased risk of cancer from CT scans' X-rays. (Source: Cancercompass News: Breast Cancer) Study Of Stubborn Breast Cancers: Group Seeks To Turn Genomic Medicine To Resistant Tumors Life Technologies said Friday it is applying its gene sequencing prowess to a challenging project: detecting genetic information about breast cancers that show no sign of obvious mutations linked with the disease. (Source: Cancercompass News: Breast Cancer) Women's experiences with genomic testing for breast cancer recurrence risk This study examined how women receive and incorporate results of Oncotype DX, a genomic test that offers recurrence risk estimates, into decisions about adjuvant treatment for early stage breast cancer.Participants in the cross-sectional study were 77 women with early stage, estrogen receptor-positive breast cancer with 0 to 3 positive lymph nodes who received Oncotype DX between 2004 and 2009. Mailed surveys, supplemented by medical chart review, assessed how women received and understood recurrence risk information based on the test.The most common test results were low (50%, 34 of 68) or intermediate (37%, 25 of 68) breast cancer recurrence risk. Most women accurately recalled their recurrence risk based on the test (71%) and felt they understood much of what they were told about it (67... Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population Authors: W Chai, G Maskarinec
& R V Cooney (Source: European Journal of Clinical Nutrition)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors REDWOOD CITY, Calif., March 8 /PRNewswire-FirstCall/ -- Genomic
Health, Inc. (NASDAQ:GHDX) today announced the publication of
positive results from a large international study which
demonstrated that the Oncotype DX® breast cancer... (Source: Drugs.com - Clinical Trials) Medifocus, Inc. Announces That It Has Received Approval to Initiate Its Pivotal Phase III Clinical Trial for Treatment of Breast Cancer from the Food and Drug Administration (FDA), Investigational Device Exemption (IDE) Application VANCOUVER, British Columbia--(HSMN NewsFeed)--Medifocus Inc. (OTC:MDFZF.PK and TSXV:MFS) is pleased to announce that it has received from the Food and Drug Administration (FDA) an Investigational Device Exemption (IDE) approval to initiate a pivotal Phase ... Devices, Oncology, FDAMedifocus, Microfocus, hyperthermia therapy, breast cancer (Source: HSMN NewsFeed) Experiment seeks blood test for breast cancer WASHINGTON (Reuters) - An experimental approach that looks for the DNA leaking out from dead and dying cells may provide a route to a blood test for breast cancer, U.S. researchers reported on Tuesday. (Source: Reuters: Health) Experiment Seeks Blood Test for Breast Cancer An experimental approach that looks for the DNA leaking out from dead and dying cells may provide a route to a blood test for breast cancer, U.S. researchers reported on Tuesday.
Source: Reuters Health
Related MedlinePlus Pages: Breast Cancer, Laboratory Tests (Source: MedlinePlus Health News) Study Identifies Need to Improve Communication of Breast Cancer Recurrence Risk One fourth of women choosing breast cancer treatment do not achieve their preferred decision-making style. Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> After Cancer, Removing a Healthy Breast A procedure gains popularity but doesn't improve survival odds. (Source: NYT > Health) Maybe no radiation for early breast cancer ST. LOUIS, March 9 (UPI) -- U.S. researchers say early-stage breast cancer patients may not need radiation after a mastectomy. (Source: Health News - UPI.com) The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects. (Source: Journal of Biomedicine and Biotechnology) Breast Cancer Screening: How to Guide Black, White, and Asian Patients Why is there disparity in screening and outcome of breast cancer for US white, black, and Asian women? In light of the recent USPSTF recommendations, how can the data be put into context? Medscape Family Medicine (Source: Medscape Today Headlines) Newly Published Data Shows Chronix Biomedical's Serum DNA Assays Can Detect Early-Stage Breast Cancer Study in Molecular Cancer Research Shows Utility of Chronix’s Technology for Screening for Undiagnosed Breast Cancer and Monitoring of Cancer Recurrence
SAN JOSE, Calif.--(HSMN NewsFeed)--Chronix Biomedical today announced publication of a study that su... Diagnostics, OncologyChronix Biomedical, serum DNA, circulating DNA, breast cancer (Source: HSMN NewsFeed)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Fall in breast cancer incidence reflects decreased HRT use The incidence of invasive breast cancer in peri- and postmenopausal women fell in Scotland following a striking decrease in the use of hormone replacement therapy, research shows. (Source: MedWire News - Oncology) MRI Finds Tumors In Second Breast Of Women Diagnosed With Cancer In One Breast Postmenopausal women, including those over 70 years old, who have been newly diagnosed with cancer in one breast have higher cancer detection rates when the other breast is scanned for tumors with MRI, compared to premenopausal women, say researchers at the Mayo Clinic campus in Florida. They found that 3... (Source: Breast Cancer News From Medical News Today) MRI Finds Tumors In Second Breast Of Women Diagnosed With Cancer In One Breast Postmenopausal women, including those over 70 years old, who have been newly diagnosed with cancer in one breast have higher cancer detection rates when the other breast is scanned for tumors with MRI, compared to premenopausal women, say researchers at the Mayo Clinic campus in Florida. They found that 3.8 percent of 425 women had breast cancer in the undiagnosed breast that had not been found with a clinical or mammographic examination; all were postmenopausal... (Source: Health News from Medical News Today) Improvements Needed In Genomic Test Result Discussions One in three early stage breast cancer patients who received genomic testing when deciding about treatment options felt they did not fully understand their discussions with physicians about their test results and their risk of the disease recurring, a new study has found. The research, conducted by University of North Carolina at Chapel Hill investigators, also revealed about one in four women experienced distress when receiving their test results... (Source: Health News from Medical News Today) Improvements Needed In Genomic Test Result Discussions One in three early stage breast cancer patients who received genomic testing when deciding about treatment options felt they did not fully understand their discussions with physicians about their test results and their risk of the disease recurring, a new study has found... (Source: Breast Cancer News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> New study questions benefits of elective removal of ovaries during hysterectomy (Elsevier Health Sciences) Removal of the ovaries (bilateral oophorectomy) while performing a hysterectomy is common practice to prevent the subsequent development of ovarian cancer. This prophylactic procedure is performed in 55 percent of all US women having a hysterectomy, or approximately 300,000 times each year. An article in the March/April issue of t Philadelphia, PA, March 9, 2010 - Removal of the ovaries (bilateral oophorectomy) while performing a hysterectomy is common practice to prevent the subsequent development of ovarian cancer. This prophylactic procedure is performed in 55% of all U.S. women having a hysterectomy, or approximately 300,000 times each year. An article in the March/April issue of The Journal of Minimally Invasive Gynecology suggests that this procedure may do... The Attentional Function Index - a self-report cognitive measure Conclusion: The brief AFI has demonstrated usefulness for assessment of perceived cognitive functioning in populations with life-threatening and chronic illness, such as breast cancer. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Psycho-Oncology) Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer Conclusions:
Overall, there is no conclusive evidence that genetic variants in genes involved in the estrogen metabolic pathway are associated with mammographic density in postmenopausal women. (Source: Breast Cancer Research) How Breast Cancer Patients Want to Search for and Retrieve Information From Stories of Other Patients on the Internet: an Online Randomized Controlled Experiment Conclusions: Having access to the story topics search facility clearly had the most positive effect on patient satisfaction and search success. (Source: Journal of Medical Internet Research) Rapid Freezing Ups Immunity in Breast Cancer Mouse Model Rapid freezing of breast cancers kills the tumor and generates a tumor-specific immune response that
reduces metastases and improves survival compared with surgery in mice, according to a study published online Dec.
22 ahead of the print edition of the Annals of Surgical Oncology. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Arm Exercise Promotion Scale: instrument validation Conclusion. There is strong evidence to further support the Arm Exercise Promotion Scale as a valid instrument in assessing factors which promote arm exercises with patients with breast cancer. Future longitudinal clinical studies using this scale could add knowledge about the experiences of carrying out arm exercises in patients with breast cancer across time. (Source: Journal of Advanced Nursing) Comment on Pegylated Liposomal Doxorubicin Plus Docetaxel in Metastatic Breast Cancer [CORRESPONDENCE] (Source: Journal of Clinical Oncology) Significant Effect of Polymorphisms in CYP2D6 and ABCC2 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Breast Cancer Patients [Breast Cancer] Conclusion
Our results suggest that polymorphisms in CYP2D6 and ABCC2 are important predictors for the prognosis of patients with breast cancer treated with tamoxifen. (Source: Journal of Clinical Oncology) Effects of Tamoxifen and Exemestane on Cognitive Functioning of Postmenopausal Patients With Breast Cancer: Results From the Neuropsychological Side Study of the Tamoxifen and Exemestane Adjuvant Multinational Trial [Breast Cancer] Conclusion
After 1 year of adjuvant therapy, tamoxifen use is associated with statistically significant lower functioning in verbal memory and executive functioning, whereas exemestane use is not associated with statistically significant lower cognitive functioning in postmenopausal patients with BC. Our results accentuate the need to include assessments of cognitive effects of adjuvant endocrine treatment in long-term safety studies. (Source: Journal of Clinical Oncology) Neratinib, an Irreversible ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced ErbB2-Positive Breast Cancer [Breast Cancer] Conclusion
Oral neratinib showed substantial clinical activity and was reasonably well tolerated among both heavily pretreated and trastuzumab-naïve patients who had advanced, ErbB2-positive breast cancer. Diarrhea was the most common adverse effect but was manageable with antidiarrheal agents and dose modification. (Source: Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Intramedullary Spinal Metastasis From Breast Cancer [Images in Neurology] (Source: Archives of Neurology) Genomic Test Result Discussions Improvements needed in genomic test result discussions - Genomic testing is an increasingly important part of care for patients after they are diagnosed with early stage breast cancer. (Source: Disabled World) Multidrug Resistance Reversal Agent, NSC77037, Identified with a Cell-Based Screening Assay The development of multidrug resistance (MDR) remains a significant obstacle in treating cancer patients with chemotherapy. To identify small-molecule compounds that can reverse MDR, the authors used a cell-based screening assay with an MDR ovarian cancer cell line. Incubating MDR cells with a sublethal concentration of paclitaxel in combination with each of 2000 small-molecule compounds from the National Cancer Institute Diversity Set Library, they identified NSC77037. The cytotoxic activity of NSC77037 and the duration of its effect were evaluated in vitro using a panel of cancer cell lines expressing permeability glycoprotein (Pgp), multiple drug resistance protein 1 (MRP 1), and breast cancer resistance protein (BCRP). The mechanism of its effects was further analyzed by assessing the ... More Mammo Squabbles For all of my years involved with radiology, I have been a strong supporter for mammography, both for clinical uses and for screening. In my assignments with the American College of Radiology (ACR), I helped encourage mammographic technique by publicizing its development and publicizing the value of periodic mammographic screening. I was not part of the science. Rather, I was part of the promotion which gained the support of the ACR, the Public Health Service, the trainers of radiologists and technologists, the manufacturers of x-ray film and equipment, other medical societies, and the science and medical writers who told the public about the value of early detection of breast cancer. (Source: Academic Radiology) Dynamic Breast MRI in the Course of Neoadjuvant Chemotherapy: Standardized Evaluation of Tumor Size and Enhancement Parameters in Correlation to Different Histopathologic Characteristics Conclusions: From routine MRI protocol and semiquantitative analysis of signal enhancement curves, information about size, and hemodynamic status of tumors under treatment may be extracted. Reduction in size and maximum enhancement were complementary parameters. In the course of therapy, size and enhancement may develop differently in clinically relevant histopathological subgroups. (Source: Academic Radiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Genomic test result discussions A newly released study has observed that one in three early-stage patients with breast cancer who received genomic testing when deciding about therapy options felt they did not fully understand their discussions with physicians about their test results and their risk of recurrence. About one in four experienced distress when receiving their test results........ (Source: Medicineworld.org: New Article Alert) Breast Cancer Patients Often Confused by Genomic Testing Doctors should do more to explain test results, researchers find
Source: HealthDay
Related MedlinePlus Pages: Breast Cancer, Genetic Testing (Source: MedlinePlus Health News) Bisphosphonate use associated with decreased risk for breast cancer (Source: HemOncToday.com) Life Technologies, TGen And US Oncology Partner On Groundbreaking Breast Cancer Sequencing Research Life Technologies Corporation (NASDAQ:LIFE) announced that it is collaborating with the Translational Genomics Research Institute (TGen) and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies. The goal of this first-of-its-kind research collaboration is to demonstrate whether genomic sequencing of cancer tissue can provide clues for treatment strategies for these individuals... (Source: Health News from Medical News Today) Life Technologies, TGen And US Oncology Partner On Groundbreaking Breast Cancer Sequencing Research Life Technologies Corporation (NASDAQ:LIFE) announced that it is collaborating with the Translational Genomics Research Institute (TGen) and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies... (Source: Breast Cancer News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Improvements Needed In Genomic Test Result Discussions A new study has found that one in three early-stage breast cancer patients who received genomic testing when deciding about treatment options felt they did not fully understand their discussions with physicians about their test results and their risk of recurrence. About one in four experienced distress when receiving their test results. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest there is room for improvement in communicating cancer recurrence risks and treatment decisions with patients... (Source: Health News from Medical News Today) Improvements Needed In Genomic Test Result Discussions A new study has found that one in three early-stage breast cancer patients who received genomic testing when deciding about treatment options felt they did not fully understand their discussions with physicians about their test results and their risk of recurrence. About one in four experienced distress when receiving their test results... (Source: Genetics News From Medical News Today) Clinical quandary in adjuvant chemo: Endpoint versus toxicity For oncologists battling breast cancer in the clinic, one of the most difficult decisions is choosing the optimal adjuvant therapy, one that balances the fine line between efficacy and toxicity. Clifford A. Hudis, MD, Chief, Breast Cancer Medicine Service at Memorial Sloan-Kettering Cancer Center, tackled this difficult clinical discussion in an interview with ONCOLOGY. (Source: Cancer Network) ?Father of tamoxifen? foresees challenges and successes for endocrine therapy Internationally renowned breast cancer scientist, V. Craig Jordan, OBE, PhD, DSc posed an important question: Where do we go from here in endocrine therapy. In an interview with ONCOLOGY, Dr. Jordan highlighted some of the fundamental clinical issues that he explored during his presentation, ?Challenges to Improve Adjuvant Endocrine Therapy.? (Source: Cancer Network) Are genomic assays ready for prime time? A prominent investigator weighs in Next-generation genomic assay technologies are revolutionizing our ability to characterize cancers at the genomic levels, providing critical prognostic and predictive information for individual patients with breast cancer, thereby helping to guide treatment decisions. According to Harold J. Burstein, MD, PhD, Associate Professor of Medicine, Harvard Medical School, these emerging technologies will change the way we treat breast cancer. (Source: Cancer Network)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Questioning The Need For Radiation After Mastectomy In Early-Stage Breast Cancer Patients Breast cancer patients with early stage disease that has spread to only one lymph node may not benefit from radiation after mastectomy, because of the low present-day risk of recurrence following modern surgery and systemic therapy, a finding that could one day change the course of treatment for thousands of women diagnosed each year, according to researchers at The University of Texas M. D... (Source: Breast Cancer News From Medical News Today) Questioning The Need For Radiation After Mastectomy In Early-Stage Breast Cancer Patients Breast cancer patients with early stage disease that has spread to only one lymph node may not benefit from radiation after mastectomy, because of the low present-day risk of recurrence following modern surgery and systemic therapy, a finding that could one day change the course of treatment for thousands of women diagnosed each year, according to researchers at The University of Texas M. D. Anderson Cancer... (Source: Health News from Medical News Today) First-Of-Its-Kind Project Will Sequence Difficult Breast Cancers To Provide Insight Into Treatment Strategies Life Technologies Corporation (NASDAQ: LIFE) has announced that it is collaborating with the Translational Genomics Research Institute (TGen) and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies. The goal of this first-of-its-kind research collaboration is to demonstrate whether genomic sequencing of cancer tissue can provide clues for treatment strategies for these individuals... (Source: Health News from Medical News Today) First-Of-Its-Kind Project Will Sequence Difficult Breast Cancers To Provide Insight Into Treatment Strategies Life Technologies Corporation (NASDAQ: LIFE) has announced that it is collaborating with the Translational Genomics Research Institute (TGen) and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies... (Source: Breast Cancer News From Medical News Today) Trial launched to test new treatment for pre-invasive breast cancer Can a drug that has been used to treat malaria for years possibly be used to treat breast cancer before it becomes invasive? That's what researchers are now trying to prove. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Freezing Technique May Stop Breast Cancer Title: Freezing Technique May Stop Breast CancerCategory: Health NewsCreated: 3/5/2010 2:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Cancer General) Breast Cancer Patients Often Confused by Genomic Testing Title: Breast Cancer Patients Often Confused by Genomic TestingCategory: Health NewsCreated: 3/8/2010 9:42:00 AMLast Editorial Review: 3/8/2010 (Source: MedicineNet Cancer General) Freezing Technique May Stop Breast Cancer Title: Freezing Technique May Stop Breast CancerCategory: Health NewsCreated: 3/5/2010 2:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Womens Health General) Breast Cancer Patients Often Confused by Genomic Testing Title: Breast Cancer Patients Often Confused by Genomic TestingCategory: Health NewsCreated: 3/8/2010 9:42:00 AMLast Editorial Review: 3/8/2010 (Source: MedicineNet Womens Health General) Improvements needed in genomic test result discussions (American Cancer Society) A new study has found that one in three early-stage breast cancer patients who received genomic testing when deciding about treatment options felt they did not fully understand their discussions with physicians about their test results and their risk of recurrence. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> One third of breast cancer patients feel they do not fully understand their genomic testing results A new study has found that one in three early-stage breast cancer patients who received genomic testing when deciding about treatment options felt they did not fully understand their discussions with physicians about their test results and their risk of recurrence. (Source: ScienceDaily Headlines) Cancer Gene Test Results Often Not Well Explained Discussions of genetic test results for breast cancer recurrence risk frequently miss the mark for patient comprehension, according to a survey of women with early-stage breast cancer. (Source: MedPage Today Hematology/Oncology) FOXM1 is a transcriptional target of ER? and has a critical role in breast cancer endocrine sensitivity and resistance FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistance
Oncogene advance online publication, March 8, 2010. doi:10.1038/onc.2010.47
Authors: J Millour, D Constantinidou, A V Stavropoulou, M S C Wilson, S S Myatt, J M-M Kwok, K Sivanandan, R C Coombes, R H Medema, J Hartman, A E Lykkesfeldt
& E W-F Lam (Source: Oncogene) Breast cancer follow-up inconsistent Cancer specialists provide more consistent and comprehensive American Society of Clinical Oncology-recommended breast cancer follow-up care than primary care physicians, US research shows. (Source: MedWire News - Oncology) Medical Menopause Medical menopause is different than natural and surgical menopause. It may occur during treatment for breast cancer. Learn more about the specifics and causes of medical menopause. (Source: About.com Breast Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer Conclusions:
HJURP mRNA level is a prognostic factor for disease-free and overall survival in patients with breast cancer and is a predictive biomarker for sensitivity to radiotherapy. (Source: Breast Cancer Research) Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells Conclusion:
Combination treatment of gamma-tocotrienol with specific ErbB receptor inhibitors is more effective in reducing mammary tumor cell growth and viability than high dose monotherapy, suggesting that targeting multiple ErbB receptors with combination therapy may significantly improve the therapeutic response in breast cancer patients. (Source: BMC Cancer) Genomic Testing Discussions for Recurrence Risk Evaluated Although results conveyed by physicians regarding genomic testing for breast cancer recurrence may be
understood by most women, a significant number do not completely understand genomic-based recurrence risk
discussions, suggesting the need for improved risk communication and treatment decision making between patients and
physicians, according to a study published online March 8 in Cancer. (Source: Modern Medicine) The effect of designed exercise programme on quality of life in women with breast cancer receiving chemotherapy Conclusion: Based on the study findings, it is recommended that this programme can be employed as an effective means of improving the QOL among patients with breast cancer. (Source: Scandinavian Journal of Caring Sciences) Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer. CONCLUSIONS: Weekly PCb regimen was very active and tolerable as neoadjuvant treatment of breast cancer. This weekly PCb regimen should consider as a reasonable nonanthracycline-containing option in the neoadjuvant treatment of breast cancer.
PMID: 20211870 [PubMed - as supplied by publisher] (Source: Ann Oncol)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Network Properties for Ranking Predicted miRNA Targets in Breast Cancer MicroRNAs control the expression of their target genes by translational repression and transcriptional cleavage. They are involved in various biological processes including development and progression of cancer. To uncover the biological role of miRNAs it is important to identify their target genes. The small number of experimentally validated target genes makes computer prediction methods very important. However, state-of-the-art prediction tools result in a great number of putative targets with an unpredictable number of false positives. In this paper, we propose and evaluate two approaches for ranking the biological relevance of putative targets of miRNAs which are associated with breast cancer. (Source: Advances in Bioinformatics) Metastatic Breast Cancer or Multiple Myeloma? Camouflage by Lytic Lesions This report addresses the pitfalls of overlapping symptoms and the question of which patients with suspected metastatic disease should undergo a biopsy. (Source: Journal of Oncology) NIH Student Award Winner Exploring How Couples Cope With Breast Cancer Amber J. Belcher, a doctoral student in psychology at the University of Delaware, has won the Ruth L. Kirschstein National Research Service Award from the National Institutes of Health (NIH). The fellowship will support Belcher's research on how couples cope with breast cancer. Breast cancer is second only to skin cancer as the most common cancer among women in the United States. According to the American Cancer Society, every year nearly 200,000 women are diagnosed with invasive breast cancer in the United States and over 40,000 die from the disease... (Source: Health News from Medical News Today) NIH Student Award Winner Exploring How Couples Cope With Breast Cancer Amber J. Belcher, a doctoral student in psychology at the University of Delaware, has won the Ruth L. Kirschstein National Research Service Award from the National Institutes of Health (NIH). The fellowship will support Belcher's research on how couples cope with breast cancer. Breast cancer is second only to skin cancer as the most common cancer among women in the United States... (Source: Breast Cancer News From Medical News Today) Axxent eBx Axxent electronicbrachytherapy treatment system can give you accelerated partial breast radiation without using a radioactive source. Electronic brachytherapy uses a miniature X-ray source to produce radiation, instead of radioactive isotopes. Learn more about electronic brachytherapy here. (Source: About.com Breast Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products Authors: Oded Kleifeld, Alain Doucet, Ulrich auf dem Keller, Anna Prudova, Oliver Schilling, Rajesh K Kainthan, Amanda E Starr, Leonard J Foster, Jayachandran N Kizhakkedathu & Christopher M Overall
Effective proteome-wide strategies that distinguish the N-termini of proteins from the N-termini of their protease cleavage products would accelerate identification of the substrates of proteases with broad or unknown specificity. Our approach, named terminal amine isotopic labeling of substrates (TAILS), addresses this challenge by using dendritic polyglycerol aldehyde polymers that remove tryptic and C-terminal peptides. We analyze unbound naturally acetylated, cyclized or labeled N-termini from proteins and their protease cleavage products by tandem mass spectrometry, and use peptide iso... Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53. Authors: Carney BK, Cassimeris L
Stathmin, a microtubule regulatory protein, is overexpressed in many cancers and required for survival of several cancer lines. In a study of breast cancer cell lines, Alli et al. (Oncogene. 26:1003-12) proposed that stathmin is required for survival of cells lacking p53, but this hypothesis was not tested directly. Here we tested their hypothesis by examining cell survival in cells depleted of stathmin, p53 or both proteins. Comparing HCT116 colon cancer cell lines differing in TP53 genotype, stathmin depletion resulted in significant death only in cells lacking p53. As a second experimental system, we compared the effects of stathmin depletion from HeLa cells, which normally lack detectable levels of p53 due to expression of the HPV E6 protein. Stathm... [The Accuracy of HADS and GHQ-12 in Detecting Psychiatric Morbidity in Breast Cancer Patients.] CONCLUSION: The HADS Unitary Scale and its subscales were effective in identifying affective disorders. They can be used as screening measures in breast cancer patients. The GHQ-12 was less accurate in detecting affective disorders than the HADS, but it can also be used as a screening instrument to detect affective disorders, generalized anxiety disorder, and DSM major depression.
PMID: 20204904 [PubMed - in process] (Source: Turkish Journal of Psychiatry) Plasma estradiol link to gene expression in ER-positive breast cancers Plasma estradiol levels are associated with estrogen-responsive gene expression in estrogen receptor-positive breast cancers, study findings indicate. (Source: MedWire News - Breast Cancer) SSO: Radiation After Mastectomy May Be Overused (CME/CE) ST. LOUIS (MedPage Today) -- Many women who undergo mastectomy for early-stage breast cancer may not benefit from radiotherapy, a retrospective, single-center study suggested. (Source: MedPage Today Hematology/Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> SSO: Radiation After Mastectomy May Be Overused (CME/CE) ST. LOUIS (MedPage Today) -- Many women who undergo mastectomy for early-stage breast cancer may not benefit from radiotherapy, a retrospective, single-center study suggested. (Source: MedPage Today Hematology/Oncology) Most early-stage breast cancer patients may not need radiation after mastectomy (University of Texas M. D. Anderson Cancer Center) Breast cancer patients with early stage disease that has spread to only one lymph node may not benefit from radiation after mastectomy, because of the low present-day risk of recurrence following modern surgery and systemic therapy, a finding that could one day change the course of treatment for thousands of women diagnosed each year, according to researchers at the University of Texas M. D. Anderson Cancer. (Source: EurekAlert! - Medicine and Health) Most early-stage breast cancer patients may not need radiation after mastectomy Breast cancer patients with early stage disease that has spread to only one lymph node may not benefit from radiation after mastectomy, because of the low present-day risk of recurrence following modern surgery and systemic therapy, a finding that could one day change the course of treatment for thousands of women diagnosed each year, according to researchers. (Source: ScienceDaily Headlines) Most early stage breast cancer patients may not need radiation after mastectomy (University of Texas M. D. Anderson Cancer Center) Breast cancer patients with early stage disease that has spread to only one lymph node may not benefit from radiation after mastectomy, because of the low present-day risk of recurrence following modern surgery and systemic therapy, a finding that could one day change the course of treatment for thousands of women diagnosed each year, according to researchers at the University of Texas M. D. Anderson Cancer. (Source: EurekAlert! - Cancer) MSU Researcher Linking Breast Cancer Patients With Alternative Therapies Biological-based therapies such as diet supplements and vitamins are the most popular complementary and alternative medicines for women recovering from breast cancer, according to a Michigan State University researcher working to create a support intervention for women in treatment for the disease. (Source: Cancercompass News: Breast Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring Conclusions:
Substituting canola oil for corn oil is an easy dietary change for people to make; such a change to the maternal diet may decrease risk for breast cancer in the daughter. (Source: BMC Cancer) Acupuncture eases breast cancer therapy NEW YORK, March 5 (UPI) -- U.S. researchers say acupuncture may relieve joint pain often accompanying breast cancer treatment. (Source: Health News - UPI.com) Freezing Technique May Stop Breast Cancer Rapid cryoablation kept cancer from spreading in mice, researchers say
Source: HealthDay
Related MedlinePlus Page: Breast Cancer (Source: MedlinePlus Health News) Classification of HER2 Receptor Status in Breast Cancer Tissues by MALDI Imaging Mass Spectrometry Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research) Breast Cancer, Depression, Culture, and Marital Conflict Breast cancer is the most common form of cancer and the second leading cause of death in middle-age women. Several psychological, cultural, and systemic factors can exacerbate the course of this disease and complicate its treatment and recovery. These include clinical depression, cultural factors, and marital dynamics, particularly marital conflict. Individual and couples counseling can be essential for effective medical treatment and clinical outcomes. A case example illustrates these points. (Source: The Family Journal)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Exercise Produces Hormone Changes That May Cut Breast Cancer Risk A year-long aerobic exercise program for sedentary postmenopausal women produced hormone changes that may reduce the risk of breast cancer, researchers say. Reuters Health Information (Source: Medscape Ob/Gyn & Women's Health Headlines) Molecular Biology: Acting Out of Character The steroid receptor coactivator 3 gene, SRC-3, was identified in a region on chromosome 20 that was frequently amplified in breast cancer. The SRC-3 protein was shown to act in ? [Read more] (Source: Editors' Choice) c-Jun Induces Mammary Epithelial Cellular Invasion and Breast Cancer Stem Cell Expansion [Cell Biology] The molecular mechanisms governing breast tumor cellular self-renewal contribute to breast cancer progression and therapeutic resistance. The ErbB2 oncogene is overexpressed in ~30% of human breast cancers. c-Jun, the first cellular proto-oncogene, is overexpressed in human breast cancer. However, the role of endogenous c-Jun in mammary tumor progression is unknown. Herein, transgenic mice expressing the mammary gland-targeted ErbB2 oncogene were crossed with c-junf/f transgenic mice to determine the role of endogenous c-Jun in mammary tumor invasion and stem cell function. The excision of c-jun by Cre recombinase reduced cellular migration, invasion, and mammosphere formation of ErbB2-induced mammary tumors. Proteomic analysis identified a subset of secreted proteins (stem cell factor (SC... Non-visual Arrestins Are Constitutively Associated with the Centrosome and Regulate Centrosome Function [Signal Transduction] In addition to regulating receptor activity, non-visual arrestins function as scaffolds for numerous intracellular signaling cascades and as regulators of gene transcription. Here we report that the two non-visual arrestins, arrestin2 and arrestin3, localize to the centrosome, a key organelle involved in microtubule nucleation and bipolar mitotic spindle assembly. Both arrestins co-localized with the centrosomal marker -tubulin during interphase and mitosis and were found in purified centrosome preparations. In vitro binding assays demonstrated that both arrestins directly interact with -tubulin. Knockdown of either arrestin by RNA interference resulted in multinucleation, centrosome amplification, and mitotic defects, although only the loss of arrestin2 triggered aberrant microtubule nucl... Foxp3 Expression in p53-dependent DNA Damage Responses [Signal Transduction] The forkhead transcription factor, Foxp3, is thought to act as a master regulator that controls (suppresses) expression of the breast cancer oncogenes, SKP2 and HER-2/ErbB2. However, the mechanisms that regulate Foxp3 expression and thereby modulate tumor development remain largely unexplored. Here, we demonstrate that Foxp3 up-regulation requires p53 function, showing that Foxp3 expression is directly regulated by p53 upon DNA damage responses in human breast and colon carcinoma cells. Treatment with the genotoxic agents, doxorubicin or etoposide, induced Foxp3 expression in p53-positive carcinoma cells, but not in cells lacking p53 function. Furthermore, knock down of endogenous wild-type p53 using RNA interference abrogated Foxp3 induction by genotoxic agents, and exogenous expression o...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Prolactin Enhances Insulin-like Growth Factor I Receptor Phosphorylation by Decreasing Its Association with the Tyrosine Phosphatase SHP-2 in MCF-7 Breast Cancer Cells [Signal Transduction] Normal mammary development requires coordinated interactions of numerous factors, including prolactin (PRL) and insulin-like growth factor I (IGF-I), both of which have also been implicated in breast cancer pathogenesis and progression. We previously reported that PRL and IGF-I synergize in breast cancer cells to activate ERK1/2 and AKT, leading to increased proliferation, survival, and invasion. Intriguingly, PRL co-treatment with IGF-I augments IGF-I receptor (IGF-IR) phosphorylation 2-fold higher than IGF-I alone. Here, we showed the importance of the tyrosine phosphatase SHP-2 in this cross-talk using pharmacological inhibition and small interfering RNA. SHP-2 recruitment to IGF-IR was significantly attenuated by PRL co-treatment. Src family kinase activity was required for IGF-IR asso... Common Osteoporosis Drugs Are Associated With a Decrease in Risk of Breast Cancer SEATTLE, March 5 /PRNewswire/ -- Women who take some types of
bone-building drugs used to prevent and treat osteoporosis may be
at lower risk of breast cancer, according to a study by U.S.
researchers published today in the British Journal of... (Source: Drugs.com - Clinical Trials) A multiprotein complex involved in the DNA damage response network of Fanconi anemia, breast cancer, and Bloom syndrome The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA repair is present in all organisms examined including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. The members of the DNA Repair Interest Group perform research in areas including DNA repair enzymology and fine structure, mutagenesis, gene and cell cycle regulation, protein structure, and human disease.
For more information, visit the
DNA Repair Interest GroupAir date: 3/16/2010 12:30:00 PM (Source: Videocast - All Events) Certain Bone Drugs May Lower Breast Cancer Risk Benefit from Fosamax, Boniva, Zometa does not apply to obese women, however
Source: HealthDay
Related MedlinePlus Pages: Breast Cancer, Medicines, Osteoporosis (Source: MedlinePlus Health News) Acupuncture ?promising? for aromatase inhibitor-related joint pain A 6-week course of acupuncture therapy improves joint pain, stiffness, and functional ability in women with aromatase inhibitor-induced arthralgia, study findings indicate. (Source: MedWire News - Breast Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Acupuncture may relieve joint pain caused by some breast cancer treatments A new study demonstrates that acupuncture may be an effective therapy for joint pain and stiffness in breast cancer patients who are being treated with commonly used hormonal therapies. (Source: ScienceDaily Headlines) SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors Motivation: Next-generation sequencing (NGS) has enabled whole genome and transcriptome single nucleotide variant (SNV) discovery in cancer. NGS produces millions of short sequence reads that, once aligned to a reference genome sequence, can be interpreted for the presence of SNVs. Although tools exist for SNV discovery from NGS data, none are specifically suited to work with data from tumors, where altered ploidy and tumor cellularity impact the statistical expectations of SNV discovery.
Results: We developed three implementations of a probabilistic Binomial mixture model, called SNVMix, designed to infer SNVs from NGS data from tumors to address this problem. The first models allelic counts as observations and infers SNVs and model parameters using an expectation maximization (EM) algori... Acupuncture May Relieve Joint Pain Caused By Some Breast Cancer Treatments A new study, led by researchers at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center, demonstrates that acupuncture may be an effective therapy for joint pain and stiffness in breast cancer patients who are being treated with commonly used hormonal therapies. Results were published in the Journal of Clinical Oncology. Joint pain and stiffness are common side effects of aromatase inhibitor therapy, in which the synthesis of estrogen is blocked... (Source: Health News from Medical News Today) Acupuncture May Relieve Joint Pain Caused By Some Breast Cancer Treatments A new study, led by researchers at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center, demonstrates that acupuncture may be an effective therapy for joint pain and stiffness in breast cancer patients who are being treated with commonly used hormonal therapies. Results were published in the Journal of Clinical Oncology... (Source: Pain / Anesthetics News From Medical News Today) Stick With Older Mammography Recommendations, Stanford Experts Say At a recent community education program, Stanford experts on women's cancer disagreed with controversial new federal guidelines on breast cancer screening. The new guidelines, released in November by the U.S. Preventive Services Task Force, would delay a woman's first mammogram by 10 years, reduce future screenings from annual to every other year, and end them after age 74... (Source: Breast Cancer News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Stick With Older Mammography Recommendations, Stanford Experts Say At a recent community education program, Stanford experts on women's cancer disagreed with controversial new federal guidelines on breast cancer screening. The new guidelines, released in November by the U.S. Preventive Services Task Force, would delay a woman's first mammogram by 10 years, reduce future screenings from annual to every other year, and end them after age 74... (Source: Health News from Medical News Today) Life Technologies, TGen and US Oncology Partner on Groundbreaking Breast Cancer Sequencing Research Life Technologies Corporation (NASDAQ: LIFE) today announced that it is collaborating with TGen and US Oncology to sequence the genomes... (Source: TGen News) Certain Bone Drugs May Lower Breast Cancer Risk Title: Certain Bone Drugs May Lower Breast Cancer RiskCategory: Health NewsCreated: 3/5/2010 10:10:00 AMLast Editorial Review: 3/5/2010 (Source: MedicineNet Cancer General) Certain Bone Drugs May Lower Breast Cancer Risk Title: Certain Bone Drugs May Lower Breast Cancer RiskCategory: Health NewsCreated: 3/5/2010 10:10:00 AMLast Editorial Review: 3/5/2010 (Source: MedicineNet Senior Health General) Certain Bone Drugs May Lower Breast Cancer Risk Title: Certain Bone Drugs May Lower Breast Cancer RiskCategory: Health NewsCreated: 3/5/2010 10:10:00 AMLast Editorial Review: 3/5/2010 (Source: MedicineNet Womens Health General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Certain Bone Drugs May Lower Breast Cancer Risk Title: Certain Bone Drugs May Lower Breast Cancer RiskCategory: Health NewsCreated: 3/5/2010 10:10:00 AMLast Editorial Review: 3/5/2010 (Source: MedicineNet Arthritis General) Life Technologies, TGen and US Oncology partner on groundbreaking breast cancer sequencing research (The Translational Genomics Research Institute) Life Technologies Corporation today announced that it is collaborating with the Translational Genomics Research Institute and US Oncology to sequence the genomes of 14 patients afflicted with triple negative breast cancer whose tumors have progressed despite multiple other therapies. (Source: EurekAlert! - Medicine and Health) Acupuncture may relieve joint pain A newly released study, led by scientists at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center, demonstrates that acupuncture appears to be an effective treatment for joint pain and stiffness in patients with breast cancer who are being treated with usually used hormonal therapies. Results were reported in the Journal of Clinical Oncology....... (Source: Medicineworld.org: New Article Alert) Frequency of Cervical Cancer and Breast Cancer Screening in HIV?Infected Women in a County-Based HIV Clinic in the Western United States Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women) Prediction of breast cancer sensitivity to neoadjuvant chemotherapy
based on status of DNA damage repair proteins Conclusions:
High performing DDR focus formation resulted in tumor resistance to DNA damage-inducing chemotherapy. Our results suggested an importance of evaluation of DDR competence to predict breast cancer chemosensitivity, and merits further studying into its usefulness in exclusion of non-responder patients. (Source: Breast Cancer Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Effects of lovastatin on breast cancer cells: a proteo-metabonomic study Conclusions:
The combination of proteomics and metabonomics enabled us to identify several key targets essential to the antitumor activity of lovastatin. Our results imply that lovastatin has the potential to reduce the growth of breast cancer cells. (Source: Breast Cancer Research) Identification of 5 novel genes methylated in breast and other epithelial cancers Conclusion:
The combination of the MIRA assay with CpG island arrays is a very useful technique for identifying epigenetically inactivated genes in cancer genomes and can provide molecular markers for early cancer diagnosis, prognosis and epigenetic therapy. (Source: Molecular Cancer) Comparison of immunohistochemistry assays and real-time reverse transcription–polymerase chain reaction for analyzing hormone receptor status in human breast carcinoma The estrogen receptor (ER) and progesterone receptor (PgR) status of 163 surgical breast cancer specimens determined on real-time quantitative reverse transcription[ndash]polymerase chain reaction (RT-PCR) using frozen tumor tissue were compared with that determined using three automated immunohistochemistry (IHC) assays including Dako (Glostrup, Denmark), Ventana (Tucson, AZ, USA) and BioGenex (San Ramon, CA, USA) assay. All specimens were semiquantified according to the Allred score and J-score. The cut-offs for ER determined by log (ER/glyceraldehyde-3-phosphate dehydrogenase (GAPDH)) were [minus]3.6 and [minus]3.2 based on the Allred score and J-score, respectively, and those for PgR determined by log (PgR/GAPDH) were [minus]3.2 and [minus]2.8, respectively. The Allred total score (TS)... Vaginal radiotherapy better option for cancer Internal vaginal radiotherapy as effective as external, with fewer side-effectsRelated items from OnMedicaHerceptin of benefit in more breast cancer casesGuideline to help GPs spot cervical cancer earlyWider surgery improves endometrial Ca survivalMortality higher if using paroxetine and tamoxifenCancer survival rates not improved much in a decade (Source: OnMedica Latest News) Studies In The Area Of Breast Cancer Reported From University Of Utah To describe the current status regarding the duration of adjuvant tamoxifen and/or aromatase inhibitors in women with early-stage hormone receptor positive breast cancer. Recent findings Women with early-stage breast cancers that express estrogen and/or progesterone receptors benefit from adjuvant hormonal therapy with antiestrogen drugs, researchers in the United States report. (Source: Cancercompass News: Breast Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> New Approach To Treating Breast And Prostate Cancers In a new approach to developing treatments for breast cancer, prostate cancer and enlarged hearts, Loyola University Chicago Stritch School of Medicine researchers are zeroing in on a workhorse protein called RSK. (Source: Cancercompass News: Breast Cancer) Data On Breast Cancer Therapy Discussed By Researchers At Dana-Farber Cancer Institute Current study results from the report, 'Inflammatory breast cancer: novel preoperative therapies,' have been published. According to recent research from the United States, The treatment of inflammatory breast cancer (IBC) has been hampered by the diagnostic rarity of the disease and its consequent inclusion in clinical trials of preoperative treatment for the more indolent locally advanced breast cancer (LABC). (Source: Cancercompass News: Breast Cancer) Survey Finds Access To Mammograms Declining For Women Under Age 50 In some states women ages 40 to 49 have less access to mammograms since the U.S. Preventive Services Task Force (USPSTF) released its recommendations to change breast cancer screening guidelines last November, according to a recent survey conducted by the Avon Foundation for Women. (Source: Cancercompass News: Breast Cancer) Susan G. Komen For The Cure Concerned Federal Screening Mammography Guidelines Beginning To Limit Access For Younger Women When a federal panel late last year recommended that American women in their 40s need not get annual screening mammograms, Susan G. Komen for the Cure raised concerns that the new guidelines would result in denial of the potentially life- saving procedure for too many young women; (Source: Cancercompass News: Breast Cancer) Excellent outcomes with adjuvant toremifene or tamoxifen in early stage breast cancer Fareston (toremifene) and tamoxifen, both selective estrogen receptor modulators, are therapeutically equivalent treatments for metastatic breast cancer. We hypothesized that toremifene as compared with tamoxifen given as adjuvant therapy for early stage breast cancer would result in equivalent survival with an improved side effect profile, therefore, providing superior therapeutic efficacy.The North American Fareston versus Tamoxifen Adjuvant trial assigned 1813 perimenopausal or postmenopausal women with hormone receptor (HR)-positive invasive breast cancer to adjuvant treatment with either tamoxifen or toremifene. The primary outcomes evaluated were disease-free survival (DFS) and overall survival (OS).Median follow-up was 59 months. The baseline characteristics of the 2 treatment group...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> Q-switched YAG laser vs. punch biopsy excision for iatrogenic radiation tattoo markers – a randomized controlled trial Conclusion Q-sw YAG laser and punch biopsy excision are effective to clear iatrogenic radiation tattoo markers, but patients preferred the laser treatment because of less pronounced adverse effects. (Source: Journal of the European Academy of Dermatology and Venereology) Taking women's heart disease seriously Cardiovascular diseases have not captured public awareness as much as the seventh leading cause of
death in women: breast cancer. (Source: Modern Medicine) Arachidonic acid promotes epithelial-to-mesenchymal-like transition in mammary epithelial cells MCF10A. In conclusion, our results demonstrate, for the first time, that AA promotes an epithelial-to-mesenchymal-like transition in MCF10A human mammary non-tumorigenic epithelial cells.
PMID: 20207443 [PubMed - as supplied by publisher] (Source: European Journal of Cell Biology) Breast Cancer Testing: A Matter of Medicine or Marketing? Direct-to-consumer marketing for BRCA analysis leads women to question whether to be tested, prompting Dr. Kathy Miller to advise physicians to talk to their patients about breast cancer risk. Medscape Hematology-Oncology (Source: Medscape Today Headlines) Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP. Authors: Tolde O, Rösel D, Mierke CT, Panková D, Folk P, Vesely P, Brábek J
The newly established breast cancer cell line G3S1, derived from EM-G3 breast cancer progenitors, was analyzed for functional changes related to neoplastic progression manifested by elevated invasiveness and enhanced capability to degrade gelatin. Degradation of gelatin and invasiveness of G3S1 cells was found to be dependent on the activity of matrix proteinases and actin cytoskeletal dynamics. Therefore, the expression and activity of these proteases was compared in G3S1 and EM-G3 cells. Despite enhanced capability of G3S1 cells to degrade gelatin, these cells exhibited lower levels of secreted extracellular matrix degrading proteases than parental EM-G3 cells. However, the expression of membra...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div> PKCepsilon induces Bcl-2 by activating CREB. The objective of our present study was to determine the mode of induction of Bcl-2 by PKCepsilon in breast cancer cells. siRNA silencing of either PKCepsilon or Akt in MCF-7 cells, which overexpress Akt, decreased Bcl-2 protein and mRNA levels. However, knockdown of PKCepsilon, but not Akt, led to the decrease in Bcl-2 at both protein and mRNA levels in MDA-MB-231 breast cancer cells, which overexpress PKCepsilon but contain little constitutively-active Akt. Knockdown of PKCepsilon decreased phosphorylation of cAMP response element-binding protein (CREB) at Ser133 in MDA-MB-231 cells, and depletion of CREB by siRNA decreased Bcl-2 at both the protein and mRNA levels. In addition, knockdown of CREB sensitized MDA-MB-231 cells to TRAIL-mediated cell death. These results suggest that PKCepsil... Plant-focused diet may curb breast cancer risk NEW YORK (Reuters Health) - Diets high in vegetables, fruits and soy might cut the risk of developing breast cancer by 30 percent, new research suggests. (Source: Reuters: Health) Plant-Focused Diet May Curb Breast Cancer Risk Diets high in vegetables, fruits and soy might cut the risk of developing breast cancer by 30 percent, new research suggests.
Source: Reuters Health
Related MedlinePlus Pages: Breast Cancer, Nutrition (Source: MedlinePlus Health News) Contralateral Prophylactic Mastectomy May Benefit Small Subgroup Contralateral prophylactic mastectomy was associated with a small breast-cancer-specific survival benefit, primarily in younger women with early-stage estrogen-receptor-negative disease. Medscape Medical News (Source: Medscape Today Headlines)
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