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Salivary Gland Cancer
Detailed Guide: Salivary Gland Cancer What Is Salivary Gland Cancer? Salivary gland cancer is a cancer that starts in one of the salivary glands. It is not a single disease. There are actually several different salivary glands found inside and near your mouth. Several types of cancer and benign (non-cancerous) tumors can develop in these glands. About the salivary glands Salivary glands produce saliva, which is the lubricating fluid found in the mouth and throat. Saliva contains enzymes that begin the process of digesting food. It also contains antibodies and other substances that help prevent infections of the mouth and throat. The 2 main types of salivary glands are the major salivary glands and minor salivary glands. diagram of the salivary glands There are 3 major salivary glands, which occur in pairs: * The parotid glands, the largest salivary glands, are found on each side of the face, just in front of the ears. About 7 out of 10 salivary gland tumors start here. Most of these tumors are benign (non-cancerous), but the parotid gland is still where most malignant (cancerous) salivary gland tumors start. * The submandibular glands are smaller and are found at the back of the jaw. They secrete saliva under the tongue area. About 1 or 2 out of 10 tumors start in these glands, and about half of these tumors are benign. * The sublingual glands, which are the smallest, are found under the floor of the mouth and below either side of the tongue. Tumors starting in these glands are rare. In addition, there are several hundred minor salivary glands that are too small to see without a microscope. These glands are located beneath the lining of the lips, tongue, hard and soft palate, and inside the cheeks, nose, sinuses, and larynx (voice box). Tumors in these glands are uncommon, but they are more often malignant than benign. Benign salivary gland tumors Most salivary gland tumors are benign -- that is, they do not spread from the salivary gland to other parts of the body and are almost never life threatening. There are several types of benign salivary gland tumors, with names such as adenomas, oncocytomas, Warthin tumors, and benign mixed tumors. Benign tumors are almost always cured by surgery. Very rarely, they may become malignant (cancerous) if left untreated for a long time or if they are not completely removed and recur (grow back) several times. Only malignant tumors of the salivary glands will be discussed further in this document. Salivary gland cancers (malignant salivary gland tumors) There are many types of salivary gland cancers. Normal salivary glands are made up of several different types of cells, and tumors can start in any of these cell types. Salivary gland tumors are named according to which of these cell types they most look like when viewed under a microscope. The main types of cancers are described below. There is also a wide range in how quickly salivary gland cancers may grow and spread, with some types tending to grow faster than others. Doctors usually give these cancers a grade (from 1 to 3, or from low to high), based on how abnormal the cancers look under a microscope. The grade gives a rough idea of how quickly the cancer is likely to grow and spread. * Grade 1 cancers (also called low grade or well differentiated) look very much like normal salivary gland cells. They tend to grow slowly and have a good outcome. * Grade 2 cancers (also called intermediate grade or moderately differentiated) have an appearance and outlook that is between grade 1 and grade 3 cancers. * Grade 3 cancers (also called high grade or poorly differentiated) look quite different from normal cells and often grow and/or spread quickly. The outlook (prognosis) for these cancers is usually not as good as for lower grade cancers. Mucoepidermoid

Obese Colon Cancer Survivors Face Poorer Prognosis (HealthDay)
HealthDay - TUESDAY, March 9 (HealthDay News) -- Colon cancer survivors who are moderately or severely obese face tougher survival odds following treatment compared with their normal-weight peers, a new study reveals.
Proteins May Predict Spread of Colon Cancer (HealthDay)
HealthDay - MONDAY, March 8 (HealthDay News) -- Two proteins that might serve as biomarkers for predicting the spread of colon cancer have been identified by Chinese scientists.
New Treatment Eyed for Deadly Pancreatic Cancer (HealthDay)
HealthDay - FRIDAY, Feb. 26 (HealthDay News) -- Most pancreatic cancer patients die soon after diagnosis, but researchers have identified an oncogene that appears to be a promising new treatment target.
Hormone replacement tied to lung cancer risk (Reuters)
Reuters - Women who use hormone replacement therapy combining estrogen and progestin may have a higher risk of lung cancer than non-users, a new study finds.
Scientists Spot Genetic 'Fingerprints' of Individual Cancers (HealthDay)
HealthDay - THURSDAY, Feb. 18 (HealthDay News) -- Researchers have found a way to analyze the "fingerprint" of a cancer, and then use that fingerprint to track the trajectory of that particular tumor in that particular person.
US researchers harness DNA changes to develop cancer test (AFP)
AFP - US researchers unveiled a new way to fight cancer Thursday that uses the unique changes that occur in the DNA of cancerous cells to detect even the tiniest of cancers.
US researchers harness DNA changes to develop cancer test (AFP)
AFP - US researchers unveiled a new way to fight cancer Thursday that uses the unique changes that occur in the DNA of cancerous cells to detect even the tiniest of cancers.
New way of tracking cancer uses DNA changes: US study (AFP)
AFP - US researchers have developed a new way of tracking and fighting cancer, using patient-specific biomarkers from the DNA of individual cancer tumors, a study published Thursday showed.
Occasional binges may undo alcohol's heart benefits (Reuters)
Reuters - While research has linked moderate drinking to better heart health, a new study suggests that those benefits disappear when drinkers add the occasional binge to the mix.
Genome study shows what cancers have in common (Reuters)
Reuters - Genetic abnormalities -- missing DNA or duplicate DNA -- that fuel the growth of one type of cancer may actually be at work in several others, U.S. researchers said on Wednesday.

carcinoma Most mucoepidermoid carcinomas start in the parotid glands. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. These cancers are usually low grade, but they can also be intermediate or high grade. Low-grade mucoepidermoid tumors have a much better prognosis than high-grade ones. Adenoid cystic carcinoma Adenoid cystic carcinoma is the most common type of cancer in the minor salivary glands. It is usually slow growing and often appears to be a low-grade tumor. It is very hard to completely get rid of and often comes back after surgery, sometimes many years later. The outlook for patients with low-grade adenoid cystic carcinoma is much better than for high grade tumors of this type. Adenocarcinomas Adenocarcinoma is a term used to describe cancers that start in gland cells (cells that normally secrete a substance). There are many types of salivary gland adenocarcinomas. Acinic cell carcinoma: Most acinic cell carcinomas start in the parotid gland. They tend to be slow growing. Although they are usually low grade, how far they have invaded into nearby tissue is probably a better predictor of a patient's prognosis (outlook). Polymorphous low-grade adenocarcinoma: These tend to start in the minor salivary glands. These are usually low grade (as the name implies) and are mostly curable. Adenocarcinoma, not otherwise specified: When viewed under a microscope, these cancers have enough features to tell that they are adenocarcinomas, but not enough detail to classify them further. They are most common in the parotid glands and the minor salivary glands. These tumors can be of any grade. Rare adenocarcinomas: Several types of adenocarcinoma are quite rare. Many of these tumor types tend to be low grade and usually have a very good outcome: * basal cell adenocarcinoma * clear cell carcinoma * cystadenocarcinoma * sebaceous adenocarcinoma * mucinous adenocarcinoma Other rare adenocarcinomas are more likely to be high grade and may have a less favorable outcome: * oncocytic carcinoma * salivary duct carcinoma Malignant mixed tumors There are 3 types of malignant mixed tumors, carcinoma ex pleomorphic adenoma, carcinosarcomas, and metastasizing mixed tumor. Carcinoma ex pleomorphic adenoma accounts for the vast majority of these cancers. The other 2 are very, very rare. Carcinoma ex pleomorphic adenoma is a cancer that develops from a benign mixed tumor (also known as a pleomorphic adenoma). This occurs mainly in the major salivary glands. Both the grade and estimation of how far it has spread (stage) are important in predicting its outcome. Other rare salivary gland cancers Several other cancer types can develop in the salivary glands. Squamous cell carcinoma: This cancer occurs mainly in older men. It can develop after radiation therapy for other cancers in the area. This type of cancer tends to have a poorer outlook. Epithelial-myoepithelial carcinoma: This is a rare tumor. It tends to be low grade, but it can recur after treatment or spread to other parts of the body. Anaplastic small cell carcinoma: The cells in these tumors have nerve-like features. These tumors are most often found in minor salivary glands and tend to grow quickly. Undifferentiated carcinomas: This group of cancers includes small cell undifferentiated carcinoma, large cell undifferentiated carcinoma and lymphoepithelial carcinoma. These are high-grade cancers that often spread. Overall, the survival outlook tends to be poor. Lymphoepithelial carcinoma, which is much more common in Eskimo and Inuit people, has a slightly better outcome. Non-Hodgkin lymphoma: These cancers start in immune system cells within the salivary glands. They behave and are treated differently than other types of cancer in the salivary glands.

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Current Status of Chromoendoscopy and Narrow Band Imaging in Colonoscopy
Clinics in Colon and Rectal Surgery 2010; 23: 021-030DOI: 10.1055/s-0030-1247853ABSTRACTColonoscopy, the preferred procedure for colon cancer screening, has well-documented limitations. To improve colonoscopy's effectiveness, augmented endoscopy techniques, such as chromoendoscopy and narrow band imaging (NBI) have been evaluated. Both techniques are inexpensive, safe, and relatively easy to perform. Chromoendoscopy has an increasingly important role in surveillance of IBD, but significant work is needed to determine the optimal staining techniques and mucosal surface pattern analysis before this technique can be incorporated into routine clinical practice. NBI is a much newer technology with far less data. Well-designed prospective randomized controlled trials have failed to identify a be...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Laparoscopy for Colon and Rectal Cancer
Clinics in Colon and Rectal Surgery 2010; 23: 051-058DOI: 10.1055/s-0030-1247856ABSTRACTLaparoscopy has emerged as a useful tool in the surgical treatment of diseases of the colon and rectum. Specifically, in the application of colon cancer, a laparoscopic-assisted approach offers short-term benefits to patients while maintaining a long-term oncologic outcome. Hand-assisted laparoscopic surgery may help decrease operative times while preserving the benefits of laparoscopy. The literature on the use of laparoscopy for rectal cancer is still in its early stages. Limited data suggest short-term benefits without compromising oncologic outcome; however, data from large multicenter trials will clarify the role of laparoscopy in the treatment of rectal cancer. Robotic proctectomy is a novel techn...
Video: First Ever Live TV Anchor Colonoscopy
In Full: CBS Evening News anchor Katie Couric guided The Early Show anchor Harry Smith through a colonoscopy on live TV. Couric is an advocate of colorectal cancer prevention. (Source: Health News: CBSNews.com)
March is National Colorectal Cancer Awareness Month
March 9, 2010 - Events are taking place all around the country during March to raise awareness of colorectal cancer, which is the third most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the U.S. The American Cancer Society estimates that about 146,970 new cases and 49,920 deaths expected in 2009. (Source: NurseZone.com Nursing News)
Video: First Ever Live TV Colonoscopy
In Full: CBS Evening News anchor Katie Couric guided The Early Show anchor Harry Smith through a colonoscopy on live TV. Couric is an advocate of colorectal cancer prevention. (Source: Health News: CBSNews.com)
Obesity and Colon Cancer
Source: HealthDay - Related MedlinePlus Pages: Colorectal Cancer, Obesity (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Inside Colonoscopy Screenings
Dr. Mark Pochapin Explains How Doctors Perform This Important Test for Colon Cancer (Source: Health News: CBSNews.com)
Link Between Obesity And Poor Colon Cancer Prognosis
Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Obesity has long been established as a risk factor for cancer, but our study in colon cancer patients shows that obesity predicts a poorer prognosis after the cancer is surgically removed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic in Rochester... (Source: Health News from Medical News Today)
Link Between Obesity And Poor Colon Cancer Prognosis
Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research... (Source: Obesity / Weight Loss / Fitness News From Medical News Today)
Irritable Bowel Syndrome Patients Not More Likely To Get Colon Cancer
Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology. "Patients and doctors get nervous about the symptoms of irritable bowel syndrome (IBS)," says William D. Chey, M.D., professor of Internal Medicine at the University of Michigan Medical School. "They think the symptoms represent something more sinister... (Source: Health News from Medical News Today)
Irritable Bowel Syndrome Patients Not More Likely To Get Colon Cancer
Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology. "Patients and doctors get nervous about the symptoms of irritable bowel syndrome (IBS)," says William D. Chey, M.D... (Source: GastroIntestinal News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Recentin Did Not Meet Primary Endpoint In Horizon III Study in mCRC
Anglo-Swedish pharmaceutical company AstraZeneca plc reported on Monday that Recentin (cediranib) did not meet the primary endpoint in the Horizon III study in metastatic colorectal cancer. (Source: Cancercompass News: Colorectal Cancer)
Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer
Researchers say that obesity leads to more aggressive colon cancer and that the risk differs between men and women ROCHESTER, Minn.--(BUSINESS WIRE)--Mar 9, 2010 - It's long been known that obesity is linked to increased risk of developing... (Source: Drugs.com - Clinical Trials)
Obese Colon Cancer Survivors Face Poorer Prognosis
Study found chances of recurrence, death higher than among normal-weight patients Source: HealthDay Related MedlinePlus Pages: Colorectal Cancer, Obesity (Source: MedlinePlus Health News)
Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer
Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: News from Mayo Clinic)
Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer
Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: Mayo Clinic Research News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Mayo Researchers Link Obesity to Worse Outcome in Patients Being Treated for Colon Cancer
Researchers have found that obesity leads to more aggressive colon cancer and that the risk differs between men and women. (Source: Mayo Clinic Rochester News)
The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases
In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects. (Source: Journal of Biomedicine and Biotechnology)
Video: Peter Yarrow on Colon Health
Singer Peter Yarrow spoke with Harry Smith about the death of Mary Travers and his campaign for colon cancer prevention. (Source: Health News: CBSNews.com)
'Giant colon' promotes colorectal cancer screening
The Colorectal Cancer Association of Canada, in conjunction with government partners, has been taking a "giant colon" on the road to cities across Ontario to educate people about the disease and to promote the need for screening. (Source: CTV Health)
Menopausal Hormone Therapy Use and Risk of Invasive Colon Cancer
Does hormone replacement therapy in menopausal women decrease the risk of invasive colon cancer? American Journal of Epidemiology (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Like Little Golden Assassins, 'Smart' Nanoparticles Identify, Target And Kill Cancer Cells
Another weapon in the arsenal against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone. Led by Carl Batt, the Liberty Hyde Bailey Professor of Food Science, the researchers synthesized nanoparticles shaped something like a dumbbell made of gold sandwiched between two pieces of iron oxide. They then attached antibodies, which target a molecule found only in colorectal cancer cells, to the particles. Once bound, the nanoparticles are engulfed by the cancer cells... (Source: Health News from Medical News Today)
High weight associated with risk of colorectal tumors without microsatellite instability
The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability, a common condition in most colorectal cancers, according to a new study. (Source: ScienceDaily Headlines)
Obesity linked to poor colon cancer prognosis
(American Association for Cancer Research) Obese patients with colon cancer are at greater risk for death or recurrent disease compared to those who are within a normal weight range, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Social and Behavioral Science)
Patients with Irritable Bowel Syndrome not more likely to develop polyps, colon cancer
(University of Michigan Health System) Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies. (Source: EurekAlert! - Medicine and Health)
Metastasis of colon cancer to the thyroid gland: A case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach
Fine-needle aspiration (FNA) with cytological evaluation reliably diagnoses primary and secondary thyroid neoplasms. However, identifying the primary origin of a metastatic process involving the thyroid gland is challenging. In particular, metastasis of colon cancer to the thyroid gland is very rare. In this case report, a right lobe solid thyroid nodule in a 66-year-old male was aspirated. FNA cytology showed necrosis and atypical tall columnar cells; since, the patient at age 60 had undergone surgery for a sigmoid-rectal cancer metastasizing to the liver and subsequently to the lung, a suspicion of metastasis from colon cancer was raised. This was corroborated by cell-block immunocytochemistry showing a cytokeratin (CK) 7 negative/CK20-positive staining pattern; thyreoglobulin and TTF-1 ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Colorectal cancer screening using the faecal occult blood test (FOBt): A survey of GP attitudes and practices in the UK
Conclusions: The success of population-based screening for CRC will largely be determined by GP attitudes and support, particularly with regard to FOBt. Previous research has implied that South Asian GPs are more likely to have negative attitudes towards FOBt screening, however, our research suggests that this is not a group requiring targeted interventions to increase their support for the NHSBCSP. Of the available CRC screening tests, GPs perceived FOBt to be the most appropriate for population-based screening. (Source: BMC Family Practice)
Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis
Authors: R Zarate, J Rodríguez, E Bandres, A Patiño-Garcia, M Ponz-Sarvise, A Viudez, N Ramirez, N Bitarte, A Chopitea & J Gacía-Foncillas (Source: British Journal of Cancer AOP)
Obesity Linked to Higher Mortality Rate in Colon Cancer
In patients with colon cancer, obesity was associated with higher rates of cancer recurrence and mortality, according to research published online March 9 in Clinical Cancer Research. (Source: Modern Medicine)
Skin Toxicity Evaluation Protocol With Panitumumab (STEPP), a Phase II, Open-Label, Randomized Trial Evaluating the Impact of a Pre-Emptive Skin Treatment Regimen on Skin Toxicities and Quality of Life in Patients With Metastatic Colorectal Cancer [Gastrointestinal Cancer]
Conclusion The pre-emptive skin treatment regimen was well tolerated. The incidence of specific ≥ grade 2 skin toxicities during the 6-week skin treatment period was reduced by more than 50% in the pre-emptive group compared with the reactive group. Patients in the pre-emptive group reported less QOL impairment than patients in the reactive group. (Source: Journal of Clinical Oncology)
Facilitating Informed Decisions Regarding Microsatellite Instability Testing Among High-Risk Individuals Diagnosed With Colorectal Cancer [Gastrointestinal Cancer]
Conclusion Incorporation of new media education strategies for individuals at risk for LS may be a valuable component of the informed consent process. As clinical criteria for MSI and IHC testing continue to expand, the need for alternative educational approaches to meet this increased demand could be met by the self-administered computer-based strategy that we described. (Source: Journal of Clinical Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Optimized St. John's Wort (Hypericum perforatum L.) Germplasm Lines Exert Cytotoxicity in HT-29 Colon Cancer Cells via Downregulation of NF-?B
Extracts of two germplasm lines of St. John's wort (SJW; Hypericum perforatum L.) selected for enhanced hypericin and hyperforin content were evaluated for potential activity against colon cancer. Bioactivity was assessed in signaling pathways of tumor necrosis factor-a (TNF-?) and nuclear transcription factor-?B (NF-?B) in HT-29 colon cancer cells. Both extracts and the hypericin standard significantly inhibited growth of HT-29 cells. Levels of active NF-?B were reduced in cells treated with either of the plant extracts or hypericin, but the purified hyperforin standard was comparatively ineffective. The combination of TNF-? and SJW treatments had significantly higher cytotoxic effects, and reduced the expression of NF-?B, inhibitor of NF-?Bs (I?Ba), I?B kinase b (IKKb), and TNF ...
Rapid Expansion of Intravitreal Drug Injection Procedures, 2000 to 2008: A Population-Based Analysis [Socioeconomics and Health Services]
Conclusions  The development of vascular endothelial growth factor inhibitors has revolutionized the treatment of age-related macular degeneration. To our knowledge, this study is the first to quantify the dramatic uptake of these treatments at a population level. Our findings also suggest that off-label injection of bevacizumab was highly prevalent in Ontario. Serial intravitreal injections requiring direct physician administration and the concentration of injection procedures in the hands of a small number of ophthalmologists have the potential to affect services for other vision-threatening conditions. (Source: Archives of Opthalmology)
New Insights Into Susceptibility to Glioma [Neurological Review]
The study of inherited susceptibility to cancer has been one of the most informative areas of research in the past decade. Most of the cancer genetics studies have been focused on the common tumors such as breast and colorectal cancers. As the allelic architecture of these tumors is unraveled, research attention is turning to other rare cancers such as glioma, which are also likely to have a major genetic component as the basis of their development. In this brief review we discuss emerging data on glioma whole genome–association searches to identify risk loci. Two glioma genome-wide association studies have so far been reported. Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872)....
Positron Emission Tomography-Computed Tomography in Paraneoplastic Neurologic Disorders: Systematic Analysis and Review [Original Contribution]
Conclusion  In a paraneoplastic neurologic context, PET-CT improves the detection of cancers when other screening test results are negative, particularly in the setting of seropositivity for a neuronal nuclear or cytoplasmic autoantibody marker of cancer. Published online January 11, 2010 (doi:10.1001/archneurol.2009.336). (Source: Archives of Neurology)
Chemotherapy-Associated Peripheral Sensory Neuropathy Assessed Using In Vivo Corneal Confocal Microscopy [Images in Neurology]
(Source: Archives of Neurology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
5. A novel biomarker of axonal dysfunction in oxaliplatin-induced neurotoxicity
Introduction: Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of colorectal cancer, produces prominent dose-limiting neurotoxicity. Acute neurotoxicity develops immediately following infusion and resolves within days, while chronic neuropathy develops with higher cumulative doses. (Source: Clinical Neurophysiology)
Screening and Identification of Recombinant Anti-Idiotype Antibodies against Gastric Cancer and Colon Cancer Monoclonal Antibodies by a Phage-Displayed Single-Chain Variable Fragment Library
Several monoclonal antibodies (McAbs) have been developed that show high sensitivity and specificity to gastric cancer and colorectal cancer. However, few of the antigens recognized by these antibodies have been identified. The authors now report the selection of anti-idiotype (anti-id) antibodies of MGb1 McAb against gastric cancer and MC5 McAb against colorectal cancer using phage-displayed single-chain variable fragment (ScFv) libraries. After purification, the anti-id antibodies were approximately 30 kd and could be recognized by MGb1/MC5 McAb. Anti-id antibodies significantly blocked the binding of MGb1 and MC5 to gastric cancer/colorectal cancer cells, respectively, suggesting that the antibodies were specific to MGb1 and MC5. Antibodies against gastric and colorectal cancer could be...
Proteins May Predict Spread of Colon Cancer
Discovery could lead to blood test that would aid prevention efforts, scientist says Source: HealthDay Related MedlinePlus Page: Colorectal Cancer (Source: MedlinePlus Health News)
Recentin Did Not Meet Primary Endpoint in Horizon III Study in Metastatic Colorectal Cancer
This study,... (Source: Drugs.com - Clinical Trials)
Funny Name, Serious Goals for Colon Cancer Awareness
March is Colon Cancer Awareness month. Raising awareness of this disease is so vitally important. Colon cancer is one of the most preventable cancers, yet nearly 50,000 Americans lose their lives to colon cancer every year in the United States. It is the second leading cause of cancer deaths in the US. The Undy 5000 The Colon Cancer Alliance (CCA) is doing their part to raise awareness and funds to fight colon cancer. CCA has created a series of running races called The Undy 5000. In a funny play on words, each race is referred to as "a brief run to fight colon cancer." Each race is 5 kilometers (3.1 miles) in length, which is 5000 meters. Cancer-specific races, walks, and other events are a successful and valuable way to raise awareness and funds to fight cancer. The Undy 5000 colon cance...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
RECENTIN Did Not Meet Primary Endpoint In Horizon III Study In Metastatic Colorectal Cancer
AstraZeneca recently announced the top-line results of a Phase II/III study evaluating RECENTIN (cediranib) compared with Avastin (bevacizumab) in patients with first-line metastatic colorectal cancer (mCRC). (Source: Pharmaceutical Online News)
Colorectal Cancer In China
The incidence of colorectal cancer (CRC) in China is lower than that in the west countries, but has increased in recent years and become a substantial cancer burden in China, particularly in the more developed areas. Some studies have reported changes in the characteristics of CRC in China. However, due to a lack of an effective nation-wide surveillance system, there has been little information available on the relationship between CRC and geographical environment and economic status in China... (Source: Health News from Medical News Today)
Working outdoors reduces cancer risk
Research shows vitamin D, produced by skin when exposed to ultraviolet light, associated with reduced rate of renal cancerMen who work outdoors, enabling their bodies to create vitamins through exposure to sunlight, have a reduced risk of kidney cancer, researchers said today.In the largest study of its kind, scientists found that vitamin D ? produced by the skin when exposed to ultraviolet light ? was associated with a reduced rate of renal cancer of up to 73% among men.However, the study, published by the American Cancer Society, found that the reduced risk only applied to men ? there was no drop in renal cancer among the women studied who worked outdoors.The researchers, from the National Cancer Institute in the US, said the study of 2,500 workers in central Europe supported emerg...
Obesity Associated With Risk Of Colorectal Tumors Without Microsatellite Instability
This study was undertaken because little is know about the associations between body mass index and adult weight gain and the risk of colorectal cancer overall and by tumor MSI status. Peter T. Campbell, Ph.D... (Source: Health News from Medical News Today)
Obesity Associated With Risk Of Colorectal Tumors Without Microsatellite Instability
The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability (MSI), a common condition in most colorectal cancers, according to a new study published online March 8 in the Journal of the National Cancer Institute... (Source: Obesity / Weight Loss / Fitness News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Physicians Come Together On National Colorectal Cancer Awareness And Screening Day
Colorectal cancer (CRC) is the third leading cause of cancer death among men and women nationwide, yet only half of people who need CRC screening receive it. The American Gastroenterological Association (AGA) Institute is working to educate patients about the importance of screening and to encourage everyone age 50 and older to get screened for CRC. Recognizing that those without insurance have limited access to screening, gastroenterologists and physicians throughout the country have established free CRC screening programs for the uninsured... (Source: Health News from Medical News Today)
Elderly patients aggressively over-treated with pharmaceuticals
(NaturalNews) Researchers from the Cochrane Collaboration research group have determined that seniors over the age of 80 are being given too many drugs and in too high of doses. Particularly with high blood pressure, doctors are too aggressively treating the elderly with pharmaceuticals which is doing them more harm than good.According to the U.S. Centers for Disease Control and Prevention (CDC), nearly a quarter of all Americans between 20 and 75 have hypertension while roughly 70 percent of those over 75 have it.The conventional approach to treating high blood pressure is to prescribe a variety of drugs that, together, doctors hope will achieve a target of 140/90 mmHg. However after scouring several studies to see if such treatments are actually working, Dr. James Wright, head of Cochran...
Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility
Authors: D Krndija, H Schmid, J-L Eismann, U Lother, G Adler, F Oswald, T Seufferlein & G von Wichert (Source: Oncogene)
Prevent Cancer Foundation Promotes Colon Cancer Awareness Month
In honor of March being Colon Cancer Awareness Month, the Prevent Cancer Foundation is kicking off a tour of their Cancer Super Colon educational program. This innovative program uses a large model of the colon to raise awareness of colon cancer and educate people about colon health. People can literally "tour the colon", by walking through the life-size, medically accurate colon model. Nearly two dozen Super Colon educational events are taking place throughout the US from now through October 2010. The tour is showing up all across the country, from California, to South Dakota, Texas, Florida, Michigan, and places in between. Visit the Prevent Cancer Foundation Super Colon Website to find an event near you and for more information. Prevent Cancer Foundation Promotes Colon Cancer Awareness ...
Association between weight, colorectal cancer risk varied by microsatellite stability status
(Source: HemOncToday.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer.
Authors: Guiu B, Vincent J, Guiu S, Ladoire S, Ortega-Deballon P, Cercueil JP, Chauffert B, Ghiringhelli F Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease, resulting in increased local drug concentrations. Here we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic chemotherapy. The patient was treated with a combination of gemcitabine and oxaliplatin using HAI. The tolerance was excellent and a radiological complete response was obtained after 8 cycles of HAI. The rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this paper...
Blocking effects of siRNA on VEGF expression in human colorectal cancer cells.
CONCLUSION: VEGF, FLT-1 and FLK-1 are associated with colorectal carcinogenesis. siRNA silencing of the VEGF gene suppresses proliferation, and induces apoptosis in HCT116 cells. The results suggest that VEGF may be a new gene therapy target for colorectal cancer. PMID: 20205278 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases
Conclusions: This study describes cellular and macromolecular changes contributing to immunological escape mechanisms during metastatic growth in a colorectal liver metastases mouse model simulating the situation in human cancer. (Source: BMC Cancer)
Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines
Conclusion: This is the first study providing a simultaneous evaluation of the anti-neoplastic action of TRD across several malignant cell lines. The involvement of ROS and caspase activation was highly variable among the five cell lines, although all were susceptible to TRD induced cell death. Our results indicate, that TRD is likely to provide multifaceted cell death mechanisms leading to a cell line specific diversity. (Source: Journal of Experimental and Clinical Cancer Research)
Stathmin/oncoprotein 18, a microtubule regulatory protein, is required for survival of both normal and cancer cell lines lacking the tumor suppressor, p53.
Authors: Carney BK, Cassimeris L Stathmin, a microtubule regulatory protein, is overexpressed in many cancers and required for survival of several cancer lines. In a study of breast cancer cell lines, Alli et al. (Oncogene. 26:1003-12) proposed that stathmin is required for survival of cells lacking p53, but this hypothesis was not tested directly. Here we tested their hypothesis by examining cell survival in cells depleted of stathmin, p53 or both proteins. Comparing HCT116 colon cancer cell lines differing in TP53 genotype, stathmin depletion resulted in significant death only in cells lacking p53. As a second experimental system, we compared the effects of stathmin depletion from HeLa cells, which normally lack detectable levels of p53 due to expression of the HPV E6 protein. Stathm...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Selective Suicide Gene Therapy of Colon Cancer Exploiting the Urokinase Plasminogen Activator Receptor Promoter
(Source: BioDrugs)
Researchers find oncogene is important in pancreatic cancer growth and spread
Researchers have found that PKC-iota (PKC-i), an oncogene important in colon and lung cancers, is over-produced in pancreatic cancer and is linked to poor patient survival. They also found that genetically inhibiting PKC-i in laboratory animals led to a significant decrease in pancreatic tumor growth and spread. (Source: ScienceDaily Headlines)
A New Indicator Of Poor Prognosis In Node-Negative Colorectal Cancer Patients
Tumor budding at the invasive tumor front of colorectal cancer is recognized as an independent prognostic factor significantly related to both lymph node and distant metastasis. Several lines of evidence seem to suggest that tumor buds may, to some extent, represent malignant colorectal cancer stem cells because of their potential for migration and re-differentiation locally and at sites of metastasis... (Source: Health News from Medical News Today)
A New Indicator Of Poor Prognosis In Node-Negative Colorectal Cancer Patients
Tumor budding at the invasive tumor front of colorectal cancer is recognized as an independent prognostic factor significantly related to both lymph node and distant metastasis... (Source: Stem Cell Research News From Medical News Today)
Those Who Have Colonoscopy Performed By GIs Less Likely To Develop Colorectal Cancer
Following a negative complete colonoscopy, those who had their colonoscopies at a hospital and had their procedures performed by a non- gastroenterologist may be at a significantly increased risk of developing subsequent colorectal cancer (CRC), according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute. (Source: Cancercompass News: Colorectal Cancer)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Foxp3 Expression in p53-dependent DNA Damage Responses [Signal Transduction]
The forkhead transcription factor, Foxp3, is thought to act as a master regulator that controls (suppresses) expression of the breast cancer oncogenes, SKP2 and HER-2/ErbB2. However, the mechanisms that regulate Foxp3 expression and thereby modulate tumor development remain largely unexplored. Here, we demonstrate that Foxp3 up-regulation requires p53 function, showing that Foxp3 expression is directly regulated by p53 upon DNA damage responses in human breast and colon carcinoma cells. Treatment with the genotoxic agents, doxorubicin or etoposide, induced Foxp3 expression in p53-positive carcinoma cells, but not in cells lacking p53 function. Furthermore, knock down of endogenous wild-type p53 using RNA interference abrogated Foxp3 induction by genotoxic agents, and exogenous expression o...
Contrasting US and European approaches to colorectal cancer screening: which is best?
In the recent 1–2 decades, we have seen a considerable development in colorectal cancer (CRC) screening modalities and programme implementation, but major challenges remain. While CRC is still the second leading cause of cancer death in both the USA and Europe, there are limited data on the efficacy and effectiveness of all screening modalities except for the faecal occult blood test (FOBT). Newer screening tests, such as faecal immunochemical tests, molecular markers and CT colonography are being introduced and variably adopted, though overall rates of screening are suboptimal. Professional societies and governmental bodies have endorsed screening, though recommended approaches are quite variable, which may help to explain the great variation in screening practices. Unfortunately, q...
Low Foxp3 expression in negative sentinel lymph nodes is associated with node metastases in colorectal cancer
(Source: Gut)
Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer
Conclusion This study provides the first evidence that high VFA independently predicts a poorer outcome in patients given first-line bevacizumab-based treatment for MCC. However, this predictive biomarker needs to be validated in a different dataset. (Source: Gut)
CD10 enhances metastasis of colorectal cancer by abrogating the anti-tumoural effect of methionine-enkephalin in the liver
Conclusion CD10 expression in CRC cells abrogates the anti-tumour effect of hepatic MENK by degrading it, which enhances liver metastasis of CD10-positive CRC cells. (Source: Gut)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Body fatness and bevacizumab-based therapy in metastatic colorectal cancer
(Source: Gut)
Blood Test May Predict Colon Cancer Spread
Title: Blood Test May Predict Colon Cancer SpreadCategory: Health NewsCreated: 3/5/2010 10:50:00 AMLast Editorial Review: 3/5/2010 10:50:46 AM (Source: MedicineNet Cancer General)
Blood Test May Predict Colon Cancer Spread
(Source: eMedicineHealth.com)
High weight associated with risk of colorectal tumors without microsatellite instability
(Journal of the National Cancer Institute) The increased risk of colorectal cancer associated with obesity may be largely restricted to tumors that have no or low microsatellite instability, a common condition in most colorectal cancers, according to a new study published online March 5 in the Journal of the National Cancer Institute. (Source: EurekAlert! - Medicine and Health)
Prevalence and Factors Associated with Colorectal Cancer Screening in Canadian Women
Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Panitumumab Expands the Treatment Portfolio for Metastatic Colon Cancer
Two large studies presented at GI-ASCO demonstrate that panitumumab confirms a positive outcome in patients with metastatic colon cancer. Dr. John Marshall discusses these practice-changing findings. Medscape Hematology-Oncology (Source: Medscape Today Headlines)
Identification of 5 novel genes methylated in breast and other epithelial cancers
Conclusion: The combination of the MIRA assay with CpG island arrays is a very useful technique for identifying epigenetically inactivated genes in cancer genomes and can provide molecular markers for early cancer diagnosis, prognosis and epigenetic therapy. (Source: Molecular Cancer)
Transient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice
Conclusion: These results indicate that TRPV1 and TRPA1 could contribute to the development of thermal hyperalgesia and mechanical allodynia following cisplatin-induced painful neuropathy but that TRPV1 has a crucial role in cisplatin-induced thermal hyperalgesia in vivo. (Source: BioMed Central)
Research from University Of Pennsylvania Provides New Data On Colon Cancer
According to a study from the United States, It has been observed that survival after colorectal cancer resection is longer in women than men. The majority of these studies are in non-U.S. (Source: Cancercompass News: Colorectal Cancer)
Oxaliplatin and capecitabine in the treatment of patients with recurrent or refractory carcinoma of unknown primary site
Despite the widespread use of oxaliplatin-based regimens for colorectal and other gastrointestinal cancers, there is surprisingly little information regarding their empiric use for the treatment of carcinoma of unknown primary site (CUP). In the current study, the combination of oxaliplatin and capecitabine in patients with recurrent and refractory CUP was examined.Patients with CUP who had received at least 1 previous chemotherapy regimen were treated with oxaliplatin (130 mg/m2 intravenously on Day 1) and capecitabine (1000 mg/m2 orally twice daily on Days 1-14). Treatment cycles were repeated every 21 days. Patients with objective response or stable disease after 2 cycles continued treatment for 6 cycles or until disease progression.Nine of 48 patients (19%) had objective responses to t...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Structure elucidation of new oleanane-type glycosides from three species of Acanthophyllum.
Authors: Timité G, Mitaine-Offer AC, Miyamoto T, Ramezani M, Rustaiyan A, Mirjolet JF, Duchamp O, Lacaille-Dubois MA From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23-O-beta-D-galactopyranosylgypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (1) and gypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (2). The cytotoxicity of several of these saponins was evaluate...
Efficient co-transduction of adenoviral vectors encoding carcinoembryonic antigen and survivin into dendritic cells by the CAR-TAT adaptor molecule enhance antitumor immunity in a murine colorectal cancer model.
Authors: Kim HS, Kim CH, Park MY, Park JS, Park HM, Sohn HJ, Kim HJ, Kim SG, Oh ST, Kim TG Because multiple tumor antigens, including carcinoembryonic antigen (CEA) and survivin (SVV), have been frequently observed in human colorectal cancer, we investigated whether the expression of both CEA and SVV by co-transduction of adenovirus vectors into dendritic cells (DC) could improve antitumor immunity in a murine colorectal cancer model. The adaptor fusion protein of Coxsackie and adenovirus receptor and TAT-protein transduction domain (CAR-TAT) enhanced co-transduction of adenovirus vectors encoding CEA (AdCEA) and SVV (AdSVV) into DCs, and increased antitumor immunity. DCs expressing both CEA and SVV in the presence of CAR-TAT (DC-AdCEA/AdSVV+CAR-TAT) induced T-cell responses specific f...
MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues.
Authors: Okudaira K, Kakar S, Cun L, Choi E, Wu Decamillis R, Miura S, Sleisenger MH, Kim YS, Deng G Abundant mucin production and MUC2 expression is the key feature of mucinous colorectal cancer (CRC). Although MUC2 gene methylation has been thought to play an important role in loss of MUC2 expression, the tissues are difficult to analyze because of the cellular heterogeneity of tissue samples. In the present study, we determined the role of region-specific methylation in the MUC2 promoter in MUC2 expression in CRC. Additionally, we optimized the conditions for quantification of methylation analysis in mucinous and non-mucinous CRC tissues. We identified two regions in MUC2 promoter, region A (-289 and -274) and region C (-193 and -160), that correlated with loss of MUC2 expression by...
Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Authors: Lee HY, Crawley S, Hokari R, Kwon S, Kim YS MUC2 is a major secretory mucin normally expressed by goblet cells of the intestine, but is aberrantly expressed in colonic neoplasia. Bile acids have been implicated in colorectal carcinogenesis and, therefore, we sought to determine the effects of bile acids on MUC2 expression and regulation in colon cancer cells. Since deoxycholic acid (DCA), a secondary bile acid, has been reported to be a potent mucin secretagogue and tumor promoter, DCA-treated HM3 colon cancer cells were analyzed using promoter-reporter assays of the 5' flanking region of the MUC2 gene. Chemical inhibitors, mutant reporter constructs and EMSA showed that DCA upregulates MUC2 transcription via multiple pathways involving activation of EGFR/PKC/Ras/Raf-1/MEK1/ER...
Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells.
Authors: Saidou Balde el-H, Mégalizzi V, Cao M, Angenot L, Kiss R, Van Damme M, Frederich M Isostrychnopentamine (ISP) is an indolomonoter-penic alkaloid that is present in the leaves of Strychnos usambarensis, an East African small tree. We have reported previously pro-apoptotic effects induced in vitro by ISP in the human HCT-116 colon cancer cell line, a model that displays relative sensitivity to apoptosis. In the present study, we observed that the in vitro growth inhibitory activities of ISP are similar in cancer cells that display sensitivity versus resistance to apoptosis. We made use of the U373 glioblastoma and the A549 non-small cell lung cancer (NSCLC) cell lines as models relatively resistant to apoptosis, and the human PC-3 prostate cancer cell line as a model relati...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation.
Authors: Um HJ, Bae JH, Park JW, Suh H, Jeong NY, Yoo YH, Kwon TK Since resveratrol (3,4',5 tri-hydroxystilbene), which has been shown to inhibit multistage carcinogenesis, is not a potent cytotoxic compound, several studies were undertaken to obtain synthetic analogues of resveratrol with potent activity. We previously reported that a resveratrol derivative HS-1793 exhibits stronger antitumor effects than resveratrol in several cancer cell types. The present study was undertaken to reveal precise mechanism by which HS-1793 induces cell death. The induction of CCAAT/enhancer-binding protein-homologous protein (CHOP) and glucose-regulated protein (GRP)-78, and ER stress-specific XBP1 splicing were found in HT29 human colon carcinoma cells treated with resveratrol. Conversely, these mani...
Blood Test May Predict Colon Cancer Spread
A blood test may soon be able to predict which colon cancers are likely to spread to other parts of the body, according to a new study. (Source: WebMD Health)
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway
Biological Chemistry 391 (2/3): 171-180 Abstract A central point of regulation in the Wnt/?-catenin signalling pathway is the formation of the ?-catenin destruction complex. Axin1, an essential negative regulator of Wnt signalling, serves as a scaffold within this complex and is critical for rapid turnover of ?-catenin. To examine the mechanism by which Wnt signalling disables the destruction complex, we used an immunoprecipitation-coupled proteomics approach to identify novel endogenous binding partners of Axin1. We found mitogen-activated protein kinase kinase kinase 1 (MAP3K1) as an Axin1 interactor in Ls174T colorectal cancer (CRC) cells. Importantly, confirmation of this interaction in HEK293T cells indicated that the Axin1-MAP3K1 interaction is induced and modulated by Wnt stimula...
Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
RecQ helicase family members are involved in multiple DNA repair pathways, protecting the genome from incorrect recombination during mitosis and maintaining its stability. Deficiencies in genes encoding the RecQ helicases WRN and BLM lead to rare autosomal recessive diseases, Werner and Bloom syndromes, which have been implicated in early onset of aging, and predisposition to various types of cancer. We investigated associations of WRN, BLM and BLM-associated protein (BLAP75/RMI1) gene polymorphisms and risk of colorectal cancer (CRC), genotyping WRN V114I (rs2230009), WRN L1074F (rs2725362), WRN C1367R (rs1346044), RMI1 S455N (rs1982151) and BLM P868L (rs11852361). A large population-based case–control study, including 1795 CRC cases and 1805 controls, found no evidence for an assoc...
Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk
We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r2 cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whe...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype
A subset of colorectal cancers (CRCs) show simultaneous methylation of multiple genes; these tumors have the CpG island methylator phenotype (CIMP). CRCs with CIMP show a specific pattern of genetic alterations, including a high frequency of BRAF mutations and a low frequency of p53 mutations. We therefore hypothesized that genes inactivated by DNA methylation are involved in the BRAF- and p53-signaling pathways. Among those, we examined the epigenetic inactivation of insulin-like growth factor-binding protein 7 (IGFBP7) expression in CRCs. We found that in CRC cell lines, the silencing of IGFBP7 expression was correlated with high levels of DNA methylation and low levels of histone H3K4 methylation. Luciferase and chromatin immunoprecipitation assays in unmethylated cells revealed that p5...
Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer
H19 is an imprinted oncofetal non-coding RNA recently shown to be the precursor of miR-675. The pathophysiological roles of H19 and its mature product miR-675 to carcinogenesis have, however, not been defined. By quantitative reverse transcription–polymerase chain reaction, both H19 and miR-675 were found to be upregulated in human colon cancer cell lines and primary human colorectal cancer (CRC) tissues compared with adjacent non-cancerous tissues. Subsequently, the tumor suppressor retinoblastoma (RB) was confirmed to be a direct target of miR-675 as the microRNA suppressed the activity of the luciferase reporter carrying the 3'-untranslated region of RB messenger RNA that contains the miR-675-binding site. Suppression of miR-675 by transfection with anti-miR-675 increased RB expre...
March Is National Colorectal Cancer Awareness Month
Source: Centers for Disease Control and Prevention Related MedlinePlus Page: Colorectal Cancer (Source: MedlinePlus Health News)
Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation.
Authors: Kim WJ, Lee SJ, Choi YD, Moon SK Decursin, a pyranocoumarin isolated from the Korean Angelica gigas root, has demonstrated anti-cancer properties. In the present study, we found that decursin inhibited cell viability in cultured human urinary bladder cancer 235J cells and colon cancer HCT116 cells. The inhibited proliferation was due to apoptotic induction, because both cells treated with decursin dose-dependently showed a sub-G1 phase accumulation and an increased cytoplasmic DNA-histone complex. Cell death caused by decursin was also associated with the down-regulation of anti-apoptotic factor Bcl-2 and the up-regulation of pro-apoptotic molecules cytochrome c, caspase 3 and Bax. Treatment of both types of cancer cells with decursin resulted in G1-phase cell cycle arrest, as...
A new indicator of poor prognosis in node-negative colorectal cancer patients
(World Journal of Gastroenterology) Tumor buds are single cells or clusters of up to five cells at the invasive tumor front of colorectal tumors which are important for patient outcome and hypothesized to have stem-cell like properties. A research group in Switzerland has investigated the expression of putative cancer stem cell markers in tumor buds of patients with colorectal cancer identifying expression of ABCG5 as a frequent event associated with poor prognosis. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Colon Cancer Quiz
How much do you know about colon cancer? Your life could depend on separating factual information from myth. Test your knowledge and then test your family and friends. Quiz prepared by Dr. Waqar Qureshi Professor of Medicine, Baylor College of Medicine Chief of Endoscopy, Baylor Clinic Colorectal cancer is the third most common cancer and third leading cause of death among men and women. True: If undetected, colorectal cancer can penetrate the colon walls and spread to nearby lymph nodes, blood vessels or organs. Without early detection and treatment, the prognosis can be deadly. Colorectal cancer is almost 100% preventable. True: Understanding your risk factors and being screened regularly allows doctors to prevent colon cancer or catch the disease early enough to stop it from spreading. ...
A new indicator of poor prognosis in node-negative colorectal cancer patients
Tumor buds are single cells or clusters of up to five cells at the invasive tumor front of colorectal tumors which are important for patient outcome and hypothesized to have stem-cell like properties. A research group in Switzerland has investigated the expression of putative cancer stem cell markers in tumor buds of patients with colorectal cancer identifying expression of ABCG5 as a frequent event associated with poor prognosis. (Source: ScienceDaily Headlines)
Physicians come together on National Colorectal Cancer Awareness and Screening Day
(American Gastroenterological Association) Colorectal cancer (CRC) is the third leading cause of cancer death among men and women nationwide, yet only half of people who need CRC screening receive it. The American Gastroenterological Association Institute is working to educate patients about the importance of screening and to encourage everyone age 50 and older to get screened for CRC. (Source: EurekAlert! - Medicine and Health)
Colorectal cancer in China
(World Journal of Gastroenterology) A research team from China gained a broader picture of colorectal cancer (CRC) in Guangdong Province and provided important information on the changing epidemiology of this disease over a period of 20 years. They found that the hospitalization rate for CRC has increased over the past 20 years in Guangdong. The characteristics of CRC are different in the five hospitals located in the four different geographic areas. (Source: EurekAlert! - Medicine and Health)
Objective burden, resources, and other stressors among informal cancer caregivers: a hidden quality issue?
Conclusions: Much assistance for cancer patients is delivered in the home by informal caregivers, often without desired training, with a significant minority having limited resources and high additional demands. Future research should explore the potentially high yield of addressing caregiver needs in improving quality of cancer care and both survivors' and caregivers' outcomes. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Obesity and Receipt of Clinical Preventive Services in Veterans.
Authors: Yancy WS, McDuffie JR, Stechuchak KM, Olsen MK, Oddone EZ, Kinsinger LS, Datta SK, Fisher DA, Krause KM, Ostbye T Although obese individuals utilize health care at higher rates than their normal weight counterparts, they may be less likely to receive certain preventive services. We conducted a retrospective cohort study of veterans with visits to 136 national Veterans Affairs (VA) outpatient clinics in the United States in the year 2000. The cohort included 1,699,219 patients: 94% men, 48% white, and 76% overweight or obese. Overweight and obese patients had higher adjusted odds of receiving each of the targeted clinical preventive services as recommended over 5 years compared with normal weight patients. The odds for receiving vaccinations increased linearly with BMI category...
Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancer.
Authors: Neudecker J, Klein F, Bittner R, Carus T, Stroux A, Schwenk W, The original article to which this Corrigendum refers was published in British Journal of Surgery 2009; 96: 1458-1467. PMID: 20205211 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
The Relationship Between Mental and Physical Health
People with depression often have worse physical health, as well as worse self-perceived health, than those without depression. Depression and other physical health conditions have separate but additive effects on well-being. For example, the combination of heart disease and depression can cause twice the reduction in social interaction than either condition alone. Patients with both depression and physical health problems are at particular risk: The physical problem can complicate depression’s assessment and treatment by masking or mimicking its symptoms. It can work the other way as well. People with any chronic physical disease tend to feel more psychological distress than do healthy people. Poor physical health brings an increased risk of depression, as do the social and relati...
Virtual colonoscopy: good enough for the president but not the American public?
On Feb. 28 President Obama was screened for colorectal cancer using CT colonography. The results from this exam, also called virtual colonoscopy, along with those from the rest of the president?s annual physical, which was done at the National Naval Medical Center in Bethesda, described the president as ?fit for duty.? (Source: Diagnostic Imaging)
Latest Advances In Minimally Invasive Medicine Featured At Society Of Interventional Radiology Meeting March 13-18 In Tampa, Fla.
The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13 -18 at the Tampa Convention Center. More than 5,000 physicians, scientists and allied health professionals are expected to attend this premier IR event... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Latest Advances In Minimally Invasive Medicine Featured At Society Of Interventional Radiology Meeting March 13-18 In Tampa, Fla.
The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13 -18 at the Tampa Convention Center... (Source: Cancer / Oncology News From Medical News Today)
Virtual colonoscopy: good enough for the president but not the American public?
On Feb. 28 President Obama was screened for colorectal cancer using CT colonography. The results from this exam, also called virtual colonoscopy, along with those from the rest of the president?s annual physical, which was done at the National Naval Medical Center in Bethesda, described the president as ?fit for duty.? (Source: Cancer Network)
The Right Colorectal Cancer Test For The Right Patient
Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them... (Source: Public Health News From Medical News Today)
The Right Colorectal Cancer Test For The Right Patient
Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them. Physician experts from the American College of Gastroenterology are available to comment and help provide perspective on the many options for colorectal cancer screening during March Colorectal Cancer Awareness Month... (Source: Health News from Medical News Today)
The Right Colorectal Cancer Test For The Right Patient
Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them. Physician experts from the American College of Gastroenterology are available to comment and help provide perspective on the many options for colorectal cancer screening during March Colorectal Cancer Awareness Month... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
The Right Colorectal Cancer Test For The Right Patient
Recent reports of President Obama's CT colonography, or virtual colonoscopy, as a screening test for colorectal cancer and coverage by the Associated Press of an NIH State-of-the-Science conference heralding stool blood tests as an inexpensive alternative to colonoscopy may leave many consumers wondering which colorectal cancer test is best for them... (Source: Cancer / Oncology News From Medical News Today)
Out-of-pocket payment and cost-effectiveness of XELOX and XELOX plus bevacizumab therapy: from the perspective of metastatic colorectal cancer patients in Japan
Conclusions  We clarified the out-of-pocket payment and cost-effectiveness of chemotherapy of MCRC patients in Japan. Our previous survey shows it is highly possible that many patients prefer to pay that incremental out-of-pocket payment to gain one additional QAPFS year. However, our cost-effectiveness analysis was not conducted from the perspective of society or healthcare payers. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0045-xAuthors Takeru Shiroiwa, The University of Tokyo Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences Yakugaku-toshokan 4F, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 JapanTakashi Fukuda, The University of Tokyo Department of Health Economics and Epidemiology Research, School of Pu...
A New Era in Defining Indications for Resectability of Colorectal Cancer Liver Metastases
Abstract  Recent developments have expanded the criteria for resectability of colorectal cancer liver metastases (CRCLM). Pre-hepatectomy chemotherapy, portal venous occlusion, and two-stage hepatectomy may enable complete lesion extirpation while maintaining a liver remnant with suitable size, biliary drainage, and vascular inflow and outflow to provide sufficient hepatic function after resection. Enthusiasm for chemotherapy must be tempered by the potential deleterious effects on the non-tumor-bearing liver, which may render some patients unresectable. The presence of extrahepatic metastatic disease, multiple CRCLM, and the inability to envision a 1-cm negative resection margin no longer are absolute contraindications for surgical extirpation. Resection of CRCLM in the pr...
Laparoscopic Total Gastrectomy and D2 Lymphadenectomy
Conclusions  Thanks to laparoscopy, a meticulous lymphadenectomy can be performed under excellent view. Advantages, besides rapid recovery of bowel function, include short hospitalization and better cosmesis. Circular stapler esophagojejunostomy can easily be performed by insertion of the anvil transabdominally. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-010-0936-0Authors Giovanni Dapri, Saint-Pierre University Hospital Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery Brussels BelgiumJacques Himpens, Saint-Pierre University Hospital Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery Brussels BelgiumGuy-Bernard Cadière, Saint-Pierre University Hospital Department of Gast...
Systemic Inflammatory Response Associated with Distant Metastasis of T1 or T2 Colorectal Cancer
Conclusions  CRP and GPS are associated with distant metastasis of T1 or T2 colorectal cancer. Because of the small number of patients with stage IV disease (n = 4), a multi-center retrospective study is needed to confirm these findings. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1159-8Authors Mitsuru Ishizuka, Dokkyo Medical University Department of Gastroenterological Surgery 880 Kitakobayashi Mibu, Tochigi 321-0293 JapanHitoshi Nagata, Dokkyo Medical University Department of Gastroenterological Surgery 880 Kitakobayashi Mibu, Tochigi 321-0293 JapanKazutoshi Takagi, Dokkyo Medical University Department of Gastroenterological Surgery 880 Kitakobayashi Mibu, Tochigi 321-0293 JapanKeiichi Kubota, Dokkyo Medical University Depa...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Sociodemographic Characteristics Are Related To A Patient's Willingness To Participate In Cancer Screenings
This study appears in the March issue of the Journal of the National Medical Association. Prior studies have shown that screenings are crucial in identifying cancer in its early stages and minorities have lower screening rates for certain types of cancer, such as cervical and colorectal cancer... (Source: Health News from Medical News Today)
Researchers Fishing For Cancer Cure Discover Active DHA Derivatives
The next treatment for cancer might come from fish says a new research report published in the March 2010 print edition of the FASEB Journal (http://www.fasebj.org). In the report, scientists show that the omega-3 fatty acid, "docosahexaenoic acid" or "DHA," and its derivatives in the body kill neuroblastoma cancer cells. This discovery could lead to new treatments for a wide range of cancers, including neuroblastoma, medulloblastoma, colon, breast, and prostate cancers, among others... (Source: Health News from Medical News Today)
Natural compound in marine sponges could halt cancer metastasis
(NaturalNews) A research team at Sanford-Burnham Medical Research has discovered a natural compound found in marine sponges that reduces the movement of cancer cells. This could be an important breakthrough in stopping the often deadly spread of cancer throughout the body -- a process known as metastasis. What's more, the compound (dubbed sceptrin) is virtually non-toxic.The research, just published in the American Chemical Society (ACS) journal Chemical Biology, was headed by Sanford-Burnham scientist Kristiina Vuori, M.D., PhD, in collaboration with Phil S. Baran, Ph.D., of the Scripps Research Institute. The scientists tested the impact of sceptrin on multiple tumor cell types, including cervical, breast and lung cancer cells.To encourage cancer cells to behave like those that spread in...
New biomarkers for predicting the spread of colon cancer
(American Chemical Society) Scientists in China are reporting discovery of two proteins present in the blood of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. Their study is in ACS' Journal of Proteome Research, a monthly publication. (Source: EurekAlert! - Biology)
Psychological distress and quality of life of partners of individuals with familial adenomatous polyposis
Conclusions: Clinicians should be particularly alert for heightened distress levels in partners of patients who are themselves distressed, and among those with children. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Eat Colorfully To Prevent Colon Cancer
The message is a simple one: Colorectal cancer is preventable, treatable and beatable IF you get screened to catch the disease early, and if you eat a rainbow of foods rich in cancer- fighting nutrients and fiber and lead a lively lifestyle, incorporating exercise and a positive outlook. (Source: Cancercompass News: Colorectal Cancer)
Dress in Blue Day Aims To Raise Colon Cancer Awareness
On Friday, March 5, 2010, the Colon Cancer Alliance (CCA) is asking local communities, corporations and the general public to support awareness of colorectal cancer by Dressing in Blue. The CCA hopes Dress in Blue Day will help start a conversation about colon cancer. The goal is to spread awareness about colon cancer screening, which can reduce the risk of this disease. Why Blue? Dress in Blue Day is designed to be similar to breast cancer's pink ribbon approach. Just like the pink ribbon campaign to raise breast cancer awareness, the blue star symbol will serves as a year-round reminder of the battle against colon cancer. Why is Dress in Blue Day So Important? Colon Cancer is a highly preventable, but rarely discussed disease. Colon cancer claims the lives of nearly 50,000 Americans ever...
Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8(+) T-cells.
Authors: Crawley AM, Vranjkovic A, Young C, Angel JB Signalling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer. Many IL-2Rgamma-sharing (gamma(C)) cytokines decrease CD127 expression on CD4(+) and CD8(+) T-cells in mice (IL-2, -4, -7, -15) and in humans (IL-2, -7) suggesting a common function. IL-4 is of particular interest as it is upregulated in HIV infection and in thyroid and colon cancers. The role of IL-4 in regulating CD127 expression and IL-7 activity in human thymocytes and mature CD8(+) T-cells is unknown andwas therefore investigated. IL-4 decreased CD127 expression on all thymocyte subsets tested a...
Role of fatty acid chain length on the induction of apoptosis by newly synthesized catechin derivatives.
In this study we investigated whether the chemical modification of (-)-Epigallocatechin gallate (EGCG) could enhance its apoptosis activity. We found that one of the catechin conjugated with capric acid [(2R,3S)-3',4',5,7-Tetrahydroxyflavan-3-yl decanoate; catechin-C10] was most potent to induce apoptosis in U937 cells. C10 treatment resulted in a significant increase in reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) loss, cytochrome c release caspase-9 and caspase-3 activation. In addition to this C10 also activated extrinsic pathway significantly as evident by time-dependent increase in Fas expression and caspase-8 activity. C10 mediated cleavage of Bid may be an important event for cross talk between intrinsic and extrinsic signaling. Moreover, pre-treat...
Widespread and tissue specific age-related DNA methylation changes in mice [LETTERS]
Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may be a risk factor for human colon cancer. It is not known whether this age-related DNA methylation phenomenon is specific to human tissues. We performed comprehensive DNA methylation profiling of promoter regions in aging mouse intestine using methylated CpG island amplification in combination with microarray analysis. By comparing C57BL/6 mice at 3-mo-old versus 35-mo-old for 3627 detectable autosomal genes, we found 774 (21%) that showed increased methylation and 466 (13%) that showed decreased methylation. We used pyrosequencing to quantitatively validate the microarray data and confirmed linear age-related methyl...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Copy number abnormalities in sporadic canine colorectal cancers [LETTERS]
Human colorectal cancer (CRC) is one of the better-understood systems for studying the genetics of cancer initiation and progression. To develop a cross-species comparison strategy for identifying CRC causative gene or genomic alterations, we performed array comparative genomic hybridization (aCGH) to investigate copy number abnormalities (CNAs), one of the most prominent lesion types reported for human CRCs, in 10 spontaneously occurring canine CRCs. The results revealed for the first time a strong degree of genetic homology between sporadic canine and human CRCs. First, we saw that between 5% and 22% of the canine genome was amplified/deleted in these tumors, and that, reminiscent of human CRCs, the total altered sequences directly correlated to the tumor's progression stage, origin, and...
Five common cancers in iran.
Authors: Kolahdoozan S, Sadjadi A, Radmard AR, Khademi H Iran as a developing nation is in epidemiological transition from communicable to non-communicable diseases. Although, cancer is the third cause of death in Iran, it;s mortality are on the rise during recent decades. This mini-review was carried out to provide a general viewpoint on common cancers incidence in Iran and to explain incidental differences that may help us to establish early detection programs and investigate population risk factors. A detailed PubMed, Scopus and Google scholar search were made from 2000 to 2009. The basic inclusion criteria were all relevant studies focused on cancer epidemiological data from Iran. Overall age-standard incidence rate per 100 000 population according to primary site is 110.43 in male...
Study of 5HT3 and HT4 Receptor Expression in HT29 Cell Line and Human Colon Adenocarcinoma Tissues.
CONCLUSION: The results indicate which 5HT3 and 5HT4 receptors are significantly expressed in both colon cancer tissue and the HT29 cell line. Expression for the 5HT3 receptor is more potent. Furthermore, 5HT plays a mitogenic role in colon cancer cells and antagonists of 5HT3, and 5HT4 receptors can inhibit cancer cell growth. PMID: 20187666 [PubMed - in process] (Source: Archives of Iranian Medicine)
Role of RNA-Binding Proteins in Colorectal Carcinogenesis
Abstract  RNA-binding proteins (RBPs) play key roles in the posttranscriptional regulation of gene expression. RBPs control various posttranscriptional events, including splicing, polyadenylation, mRNA stability, transport, and translation. It is becoming apparent that RBPs play a significant role in pathophysiologic conditions such as inflammation and cancer. More importantly, we and others have begun dissecting the role of mRNA stability and translation in regulating gene expression, dysregulation of which has serious consequences for the fate of the cell. In this article, we discuss this emerging area of posttranscriptional gene regulation and the role of RBPs in the aberrant expression of proteins in tumorigenesis. Content Type Journal ArticleDOI 10.1007/s11888-010-...
Metastasectomy of Combined Liver and Lung Colorectal Cancer Metastases
Abstract  The liver is the exclusive site of metastasis in approximately 30% to 50% of patients with stage IV colorectal cancer, whereas lung metastasis occurs in 10% to 20% of patients. No single study has specifically addressed the predictors of survival after resection of synchronously diagnosed lung and liver metastases. Patients who undergo metastasectomy for simultaneous lung and liver metastases have a reported 5-year survival rate of approximately 40%. The prognostic significance of simultaneous presentation of lung and liver metastases (versus temporally separated presentations) is unclear. Other proposed predictors include short disease-free interval, patient age, and lung as first metastatic site. A paucity of data has led to a clinically driven treatment approac...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with ?-catenin
Conclusions  The results suggest that up-regulation of Lgr5 expression, especially in female patients, may play an important role in colorectal carcinogenesis, probably through the WNT/?-catenin pathway, but not involve the progression of the CRC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0903-zAuthors Xiang-Shan Fan, Nanjing University Medical School Department of Pathology, Affiliated Nanjing Drum Tower Hospital Nanjing Jiangsu People?s Republic of ChinaHong-Yan Wu, Nanjing University Medical School Department of Pathology, Affiliated Nanjing Drum Tower Hospital Nanjing Jiangsu People?s Republic of ChinaHui-Ping Yu, Nanjing University Medical School Department of Pathology, Affiliated Nanjing Drum Tower Hospital Nanjing Jiangsu...
A new sphincter-preserving operation for low rectal cancer: ultralow anterior resection and colorectal/coloanal anastomosis by supporting bundling-up method
Conclusions  Ultralow anterior resection and colorectal/coloanal anastomosis by supporting bundling-up method may be one of the best choices of sphincter-preserving operation for low rectal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0908-7Authors Fanghai Han, First Affiliated Hospital of Sun Yat-sen University Department of Gastrointestinopancreatic Surgery Guangzhou 510080 ChinaHongming Li, First Affiliated Hospital of Sun Yat-sen University Department of Gastrointestinopancreatic Surgery Guangzhou 510080 ChinaDonghua Zheng, First Affiliated Hospital of Sun Yat-sen University Department of Gastrointestinopancreatic Surgery Guangzhou 510080 ChinaHongkai Gao, West China Hospital, Sichuan University Department of General Surgery ...
Celsion Plans To Launch Phase II Program To Study ThermoDox(R) In Combination With RFA For Colorectal Liver Metastases
Celsion Corporation (Nasdaq: CLSN) announced that it will initiate a Randomized Phase II Study of Lyso-Thermosensitive Liposomal Doxorubicin (ThermoDox®) and Radiofrequency Ablation (RFA) for Colorectal Liver Metastases (CRLM). Dr. Steven K. Libutti, Professor and Vice Chairman, Department of Surgery and Director of the Montefiore-Einstein Center for Cancer Care at the Montefiore Medical Center and Albert Einstein College of Medicine in New York City, will serve as Principal Investigator for the study... (Source: Health News from Medical News Today)
Celsion Plans To Launch Phase II Program To Study ThermoDox(R) In Combination With RFA For Colorectal Liver Metastases
Celsion Corporation (Nasdaq: CLSN) announced that it will initiate a Randomized Phase II Study of Lyso-Thermosensitive Liposomal Doxorubicin (ThermoDox®) and Radiofrequency Ablation (RFA) for Colorectal Liver Metastases (CRLM). Dr. Steven K... (Source: Liver Disease / Hepatitis News From Medical News Today)
Experts call for further research into the relationship between insulin therapy and cancer
(Wiley-Blackwell) The benefits of using insulin to treat diabetes far outweigh the risks, but a new review suggests that people with diabetes, particularly type 2 diabetes, may face an increased risk of cancer and that their cancer may be modified by treatment choices. The review showed that: diabetic patients are 30 percent more likely to develop colorectal cancer and have an 82 percent higher risk of pancreatic cancer. Female diabetics face a 20 percent greater risk of breast cancer. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Insulin used to treat diabetes may be linked to increased cancer risk, review suggests
The benefits of using insulin to treat diabetes far outweigh the risks, but a new review suggests that people with diabetes, particularly type 2 diabetes, may face an increased risk of cancer and that their cancer may be modified by treatment choices. The review showed that: diabetic patients are 30 percent more likely to develop colorectal cancer and have an 82 percent higher risk of pancreatic cancer. Female diabetics face a 20 percent greater risk of breast cancer. (Source: ScienceDaily Headlines)
Society of Interventional Radiology hosts 35th Annual Scientific Meeting
(Society of Interventional Radiology) The Society of Interventional Radiology (SIR) will present the latest research on treatments for individuals with liver, breast, soft tissue, colon, prostate, lung and pancreatic cancers; painful spinal fractures; peripheral arterial disease (PAD); uterine fibroids; and more at its 35th Annual Scientific Meeting March 13-18 at the Tampa Convention Center. (Source: EurekAlert! - Medicine and Health)
Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation
Conclusion: Our results demonstrate that tumoral metabolism of SN38 is affected by PXR and point to potential therapeutic significance of PXR quantification in the prediction of irinotecan response. Furthermore, our observations are pharmacologically relevant since many patients suffering from cancer diseases are often exposed to co-medications, food additives or herbal supplements able to activate PXR. A substantial part of the variability observed among patients might be caused by such interactions. (Source: Molecular Cancer)
Preferences for colorectal cancer screening strategies: a discrete choice experiment
Authors: L Hol, E W de Bekker-Grob, L van Dam, B Donkers, E J Kuipers, J D F Habbema, E W Steyerberg, M E van Leerdam & M L Essink-Bot (Source: British Journal of Cancer AOP)
Mesalazine Reduces Mutations in Transforming Growth Factor {beta} Receptor II and Activin Type II Receptor by Improvement of Replication Fidelity in Mononucleotide Repeats.
CONCLUSIONS: 5-ASA increases replication fidelity in mononucleotide, dinucleotide, and tetranucleotide repeats and reduces mutations in tumor suppressor genes TGFBR2 and ACVR2, a finding that may provoke in vivo studies for the prevention of colorectal cancer in hereditary nonpolyposis colorectal cancer. Clin Cancer Res; 16(6); 1950-6. PMID: 20197483 [PubMed - as supplied by publisher] (Source: Cell Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth.
Authors: Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM Inhibition of angiopoietin-2 (Ang2) can slow tumor growth, but the underlying mechanism is not fully understood. Because Ang2 is expressed in growing blood vessels and promotes angiogenesis driven by vascular endothelial growth factor (VEGF), we asked whether the antitumor effect of Ang2 inhibition results from reduced sprouting angiogenesis and whether the effect is augmented by inhibition of VEGF from tumor cells. Using Colo205 human colon carcinomas in nude mice as a model, we found that selective inhibition of Ang2 by the peptide-Fc fusion protein L1-7(N) reduced the number of vascular sprouts by 46% and tumor growth by 62% over 26 days. Strikingly, when the Ang2 inhibitor was ...
3-Phosphoinositide-Dependent Protein Kinase-1 Regulates Proliferation and Survival of Cancer Cells with an Activated Mitogen-Activated Protein Kinase Pathway.
In this study, we show that the reduction of PDK1 by RNAi in melanoma and colon cancer cell lines activated in the MAPK pathway results in significant cell growth inhibition and apoptosis. Furthermore, PDK1 reduction in tumor cells resulted in impaired PAK kinase signaling, altered actin polymerization, and reduced cell migration. These studies show that PDK1 plays a pivotal role in MAPK and PI3K signaling in tumor cells. Mol Cancer Res; 8(3); 421-32. PMID: 20197379 [PubMed - as supplied by publisher] (Source: Cell Research)
The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status.
CONCLUSIONS: In this study, we found a poor prognosis in CIMP-low patients regardless of MSI screening status, and in CIMP-high patients with MSS. Although not consistently statistically significant, these results were consistent in two separate patient groups and emphasize the potential importance of CIMP and MSI status in colorectal cancer research. Clin Cancer Res; 16(6); 1845-55. PMID: 20197478 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Intratumoral as well as peritumoral lymphatic vessel invasion correlates with lymph node metastasis and unfavourable outcome in colorectal cancer
Abstract  The aim of this study was to assess the intratumoral and peritumoral distribution of lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) in colorectal cancer and their relationships with patients? clinicopathological characteristics and survival. Paraffin sections of 81 primary colorectal cancers were examined by immunohistochemical staining using monoclonal antibody D2-40. Peritumoral LVD was significantly higher than intratumoral LVD (P = 0.000). Both intratumoral LVD and peritumoral LVD were correlated with the presence of LVI (P = 0.006 and P = 0.003, respectively). LVI, intratumoral LVI and peritumoral LVI were identified, respectively in 38, 28 and 32% of the samples investigated. Both intratumoral LVI and peritum...
Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest
Summary  We evaluated the combination treatment of ethaselen (BBSKE) as a thioredoxin reductase (TrxR) inhibitor plus cisplatin (CDDP) on the human colon adenocarcinoma cell line LoVo. Therapeutic effects ranging from nearly additive to clearly synergistic demonstrated an effective combination, i.e., the cytostatic dose of CDDP could be reduced without a loss in efficacy. To further investigate the cellular response mechanisms of these favorable outcomes, we analyzed the cell-cycle profiles, mRNA expression patterns, and protein levels of several key genes after incubation with BBSKE or CDDP separately and in combination. In appropriate conditions, CDDP induced arrest at the G2/M phase accompanied by the enhanced inhibitory phosphorylation of Cdk1 and the elevated protein e...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
The duration of functioning of a subcutaneous implantable port for the treatment of hematological tumors: a single institution-based study
Conclusion  The duration of port functioning in patients with hematological tumors was comparable to that in patients with nonhematological tumors. The higher rate of BSI in the hematology group was primarily attributable to profound neutropenia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0039-8Authors Hitoshi Ohno, Takeda General Hospital Department of Hematology 28-1 Ishida-Moriminami-cho, Fushimi-ku Kyoto 601-1495 JapanChisaki Mizumoto, Takeda General Hospital Department of Hematology 28-1 Ishida-Moriminami-cho, Fushimi-ku Kyoto 601-1495 JapanYoshihiro Otsuki, Takeda General Hospital Department of Hematology 28-1 Ishida-Moriminami-cho, Fushimi-ku Kyoto 601-1495 JapanShigeru Oguma, Takeda General Hospital Department of Hematology 28-...
Colon Cancer Alliance Representatives to Ring The NASDAQ Stock Market Closing Bell
ADVISORY, March 1, 2010 (GLOBE NEWSWIRE) -- What: (Source: Medical News (via PRIMEZONE))
First Report on Cydonia oblonga Miller Anticancer Potential: Differential Antiproliferative Effect against Human Kidney and Colon Cancer Cells
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Medical oncology: IMP3 is a novel prognostic marker for colon cancer
Nature Reviews Clinical Oncology 7, 123 (2010). doi:10.1038/nrclinonc.2010.15 Author: Lisa Hutchinson Colon cancer is one of the leading causes of cancer-related mortality. Previous studies using laser capture microdissection revealed insulin-like growth factor-II mRNA-binding protein 3 (IMP3) was overexpressed in colon cancer compared with normal mucosa, indicating its role as a candidate biomarker. Therefore, Li and coauthors (Source: Nature Clinical Practice Oncology)
DNA mismatch repair and adjuvant chemotherapy in sporadic colon cancer
Nature Reviews Clinical Oncology 7, 174 (2010). doi:10.1038/nrclinonc.2009.235 Author: Frank A. Sinicrope Defective DNA mismatch repair (MMR) occurs in approximately 15% of sporadic colorectal cancers (CRCs). Multiple retrospective studies have shown that patients with MMR-deficient CRCs have a more favorable stage-adjusted prognosis compared with those who have MMR-proficient tumors. Evidence also indicates that patients with MMR-deficient colon (Source: Nature Clinical Practice Oncology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Colorectal cancer screening rates rising but still low
An NIH panel suggests eliminating financial barriers and implementing interventions to increase screening. (Source: American Medical News - PROFESSION)
Gene Signature May Improve Colon Cancer Treatment
A gene signature, first identified in mouse colon cancer cells, may help identify patients at risk of colon cancer recurrence, according to a recent study by Vanderbilt-Ingram Cancer Center researchers. The findings, published in the March issue of Gastroenterology, could help personalize treatments for colon cancer - the second leading cause of cancer-related deaths in the United States - by identifying patients most likely to benefit from chemotherapy. In its early stages, colorectal cancer is treated with surgery only... (Source: Health News from Medical News Today)
Gene Signature May Improve Colon Cancer Treatment
A gene signature, first identified in mouse colon cancer cells, may help identify patients at risk of colon cancer recurrence, according to a recent study by Vanderbilt-Ingram Cancer Center researchers... (Source: Genetics News From Medical News Today)
FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth
A novel member of the FOX family of transcription factors is implicated in colon tumorigenesis through its ability to restrict expression of the pivotal cell cycle regulator p21WAF1. (Source: Cancer Research)

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